Gene Page:PNMT

Summary?
GeneID 5409
Symbol PNMT
Synonyms PENT|PNMTase
Description phenylethanolamine N-methyltransferase
Reference MIM:171190|HGNC:HGNC:9160|Ensembl:ENSG00000141744|HPRD:07176|Vega:OTTHUMG00000133209
Gene type protein-coding
Map location 17q12
Pascal p-value 0.004
Sherlock p-value 0.557
Fetal beta -0.375
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16823058 chr2 170317903 PNMT 5409 0.08 trans
rs10230373 chr7 147962729 PNMT 5409 0.15 trans
rs7062071 chrX 17724830 PNMT 5409 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
POLR2I 0.91 0.85
AP000350.6 0.86 0.76
MRPL23 0.85 0.78
SSNA1 0.84 0.74
LAGE3 0.84 0.73
RNASEH2C 0.83 0.73
NDUFB7 0.83 0.84
NDUFA3 0.83 0.71
NDUFA11 0.82 0.75
C11orf83 0.82 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UPF2 -0.41 -0.41
MYSM1 -0.41 -0.42
GOLGA4 -0.41 -0.43
KIF5B -0.40 -0.43
BDP1 -0.40 -0.41
BTBD8 -0.40 -0.44
VPS13C -0.39 -0.39
FMNL2 -0.39 -0.43
KIF16B -0.39 -0.40
MON2 -0.39 -0.39

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TYROSINE METABOLISM 42 30 All SZGR 2.0 genes in this pathway
BIOCARTA NEUROTRANSMITTERS PATHWAY 6 5 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME AMINE DERIVED HORMONES 15 12 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 8 7 7 All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 111 69 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 133 78 All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 68 44 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL UP 13 8 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 13 30 20 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 84 48 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway