Gene Page:CLIC6

Summary?
GeneID 54102
Symbol CLIC6
Synonyms CLIC1L
Description chloride intracellular channel 6
Reference MIM:615321|HGNC:HGNC:2065|Ensembl:ENSG00000159212|Vega:OTTHUMG00000086237
Gene type protein-coding
Map location 21q22.12
Pascal p-value 0.395
Fetal beta 0.31
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.2573

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg18074297 21 36041612 CLIC6 -0.02 0.55 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17131472 chr1 91962966 CLIC6 54102 0 trans
rs1736557 chr1 171080079 CLIC6 54102 0.15 trans
rs2922180 chr3 125280472 CLIC6 54102 0.04 trans
rs2976809 chr3 125451738 CLIC6 54102 0.02 trans
rs6441080 chr3 156298934 CLIC6 54102 0.1 trans
rs7615297 chr3 156299312 CLIC6 54102 0.19 trans
rs687188 chr4 130527157 CLIC6 54102 0.09 trans
rs639864 chr4 130538020 CLIC6 54102 0.05 trans
rs12663450 chr6 38135729 CLIC6 54102 0.09 trans
rs6455226 chr6 67930295 CLIC6 54102 0.18 trans
rs2815732 chr6 73151761 CLIC6 54102 0.19 trans
rs283063 chr6 118621313 CLIC6 54102 0.19 trans
rs3823550 chr7 137346101 CLIC6 54102 0.01 trans
rs10958899 chr9 10128700 CLIC6 54102 0.2 trans
rs10958907 chr9 10131580 CLIC6 54102 0.11 trans
rs10958910 chr9 10134759 CLIC6 54102 0.05 trans
rs427497 chr9 107982791 CLIC6 54102 0.13 trans
rs9949772 chr18 31042632 CLIC6 54102 0.05 trans
rs11873703 chr18 61448702 CLIC6 54102 0.03 trans
rs6095741 chr20 48666589 CLIC6 54102 7.292E-5 trans
rs7062071 chrX 17724830 CLIC6 54102 0.03 trans
rs1545676 chrX 93530472 CLIC6 54102 0.03 trans
rs35990795 21 36085834 CLIC6 ENSG00000159212.8 3.295E-6 0.05 44146 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005247 voltage-gated chloride channel activity IEA -
GO:0031404 chloride ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006821 chloride transport IEA -
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 91 53 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA 39 25 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER B 48 22 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS UP 48 32 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 127 75 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 44 20 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 4 UP 19 12 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 1699 1705 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC