Gene Page:GPR88

Summary?
GeneID 54112
Symbol GPR88
Synonyms STRG
Description G protein-coupled receptor 88
Reference MIM:607468|HGNC:HGNC:4539|Ensembl:ENSG00000181656|HPRD:16248|Vega:OTTHUMG00000010981
Gene type protein-coding
Map location 1p21.3
Pascal p-value 0.698
Sherlock p-value 0.159
Fetal beta -1.827
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索我n PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10492950 chr1 6006571 GPR88 54112 0.07 trans
rs596985 chr1 64277034 GPR88 54112 0.11 trans
rs16838771 chr1 157511227 GPR88 54112 1.32E-10 trans
rs17601631 chr1 169800689 GPR88 54112 0.15 trans
rs6713473 chr2 11284414 GPR88 54112 0.01 trans
rs17019687 chr2 80972176 GPR88 54112 0 trans
rs17028172 chr2 103608895 GPR88 54112 4.597E-4 trans
rs195315 chr2 109673132 GPR88 54112 0.07 trans
rs16823058 chr2 170317903 GPR88 54112 0.01 trans
rs16865055 chr2 224523383 GPR88 54112 0.14 trans
snp_a-4233520 0 GPR88 54112 0.18 trans
rs1344868 chr3 21311149 GPR88 54112 0.04 trans
snp_a-4233465 0 GPR88 54112 0 trans
rs1587651 chr3 79944075 GPR88 54112 0.05 trans
rs6780018 chr3 81405814 GPR88 54112 0 trans
rs12637719 chr3 85328350 GPR88 54112 0.15 trans
rs9310002 chr3 86223414 GPR88 54112 0.03 trans
rs7642170 chr3 86251251 GPR88 54112 0.03 trans
rs10937395 chr3 189336369 GPR88 54112 0.04 trans
rs6819929 chr4 42511311 GPR88 54112 0.01 trans
rs3025740 chr4 114163593 GPR88 54112 0.09 trans
rs17011450 chr4 127630275 GPR88 54112 0.15 trans
rs11098889 chr4 127631087 GPR88 54112 0.15 trans
rs1491136 chr4 127646153 GPR88 54112 0.1 trans
rs1491137 chr4 127646180 GPR88 54112 0.1 trans
rs4277734 chr4 156916543 GPR88 54112 3.259E-4 trans
rs1922648 chr4 160458423 GPR88 54112 0.16 trans
rs7718330 chr5 16023311 GPR88 54112 0.02 trans
rs491989 chr5 31452998 GPR88 54112 0.03 trans
rs35406 chr5 33946142 GPR88 54112 0.01 trans
rs17186508 chr5 65194022 GPR88 54112 0.03 trans
rs7448080 chr5 123398097 GPR88 54112 0.14 trans
rs17165234 chr5 126403634 GPR88 54112 0.01 trans
rs1194997 chr5 146093747 GPR88 54112 0.13 trans
rs7453019 chr6 25457856 GPR88 54112 0.1 trans
rs283063 chr6 118621313 GPR88 54112 0.01 trans
rs4642501 chr6 148696792 GPR88 54112 0.01 trans
rs9397728 chr6 150514248 GPR88 54112 1.328E-5 trans
rs4320477 chr7 115490675 GPR88 54112 0.11 trans
rs11978687 chr7 136765689 GPR88 54112 0.17 trans
rs881927 chr7 155973732 GPR88 54112 0.13 trans
rs16909591 chr8 139787216 GPR88 54112 0.11 trans
rs2066315 chr10 514137 GPR88 54112 0.01 trans
rs17143455 chr10 8368252 GPR88 54112 0.02 trans
rs16922710 chr10 23087297 GPR88 54112 5.435E-4 trans
rs16922725 chr10 23100286 GPR88 54112 0.18 trans
rs10508654 chr10 23104638 GPR88 54112 2.023E-4 trans
rs16922768 chr10 23162329 GPR88 54112 0.14 trans
rs10786907 chr10 83908248 GPR88 54112 0.07 trans
rs7081986 chr10 90807242 GPR88 54112 0.05 trans
rs2296217 chr10 105780134 GPR88 54112 0.12 trans
rs11018189 chr10 129345787 GPR88 54112 0.01 trans
rs1783466 chr11 56650948 GPR88 54112 0.19 trans
rs11224488 chr11 100723105 GPR88 54112 0.18 trans
rs12580163 chr12 2134197 GPR88 54112 0.01 trans
rs4764219 chr12 15812187 GPR88 54112 0.19 trans
rs11178165 chr12 70669547 GPR88 54112 0.11 trans
rs11178166 chr12 70670585 GPR88 54112 2.545E-4 trans
rs12301144 chr12 108825968 GPR88 54112 0.06 trans
rs7303847 chr12 115691634 GPR88 54112 0.13 trans
rs4943464 chr13 37838293 GPR88 54112 0.14 trans
rs7982899 chr13 37839250 GPR88 54112 0.14 trans
rs575555 chr13 52437620 GPR88 54112 0.15 trans
rs16967008 chr13 106287437 GPR88 54112 0 trans
rs17104965 chr14 37145915 GPR88 54112 0.04 trans
rs10047895 chr14 57512171 GPR88 54112 0.07 trans
rs362341 chr14 73641457 GPR88 54112 0.18 trans
rs284907 chr15 76741568 GPR88 54112 0.04 trans
rs284904 chr15 76744301 GPR88 54112 0.12 trans
rs284898 chr15 76750694 GPR88 54112 0.11 trans
rs7171135 chr15 86479875 GPR88 54112 0.01 trans
rs4497712 chr16 11800767 GPR88 54112 0.17 trans
rs4781412 chr16 13203337 GPR88 54112 0.06 trans
rs443222 chr16 83889679 GPR88 54112 2.479E-6 trans
rs824575 chr16 83891459 GPR88 54112 2.479E-6 trans
rs11081028 chr18 3269332 GPR88 54112 2.78E-4 trans
rs1703838 chr18 33116125 GPR88 54112 0 trans
rs6120222 chr20 31890174 GPR88 54112 0.02 trans
rs11086177 chr20 45350682 GPR88 54112 0.19 trans
rs2835891 chr21 39056226 GPR88 54112 1.275E-5 trans
rs6519257 chr22 41889401 GPR88 54112 0.18 trans
rs1883665 chrX 17650382 GPR88 54112 3.005E-8 trans
rs7062071 chrX 17724830 GPR88 54112 2.755E-4 trans
rs16989685 chrX 31527328 GPR88 54112 0.08 trans
rs5974674 chrX 136410712 GPR88 54112 0.03 trans
rs7879274 chrX 145592957 GPR88 54112 2.852E-4 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
RODRIGUES DCC TARGETS DN 121 84 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 102 67 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 196 93 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 79 50 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 All SZGR 2.0 genes in this pathway