Gene Page:POMC

Summary?
GeneID 5443
Symbol POMC
Synonyms ACTH|CLIP|LPH|MSH|NPP|POC
Description proopiomelanocortin
Reference MIM:176830|HGNC:HGNC:9201|Ensembl:ENSG00000115138|HPRD:01462|Vega:OTTHUMG00000094764
Gene type protein-coding
Map location 2p23.3
Pascal p-value 3.386E-5
Sherlock p-value 0.481
Fetal beta -0.585
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的年代earch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7565427 chr2 25385637 POMC 5443 0.04 cis
rs13031634 chr2 25585652 POMC 5443 0.05 cis
rs2197741 chr3 108732108 POMC 5443 0.01 trans
rs11733243 chr4 4944450 POMC 5443 0.18 trans
rs6063623 chr20 49906075 POMC 5443 0.03 trans
rs6067724 chr20 49907840 POMC 5443 0.03 trans
rs11696172 chr20 49912433 POMC 5443 0.02 trans
rs391008 chrX 44582706 POMC 5443 0.02 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM19A1 0.78 0.84
RND1 0.72 0.77
TCEAL1 0.72 0.80
PRPS2 0.72 0.75
AC012652.1 0.71 0.75
PVRL3 0.69 0.74
FABP3 0.68 0.75
TM6SF1 0.67 0.79
IL12RB2 0.67 0.77
R3HDM1 0.67 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SORBS3 -0.51 -0.56
PLXNB1 -0.49 -0.49
CASKIN2 -0.45 -0.47
NFKB2 -0.42 -0.51
TRIP6 -0.42 -0.49
EML3 -0.41 -0.43
MAPKAPK3 -0.41 -0.45
ACP6 -0.41 -0.43
SLC9A3R1 -0.40 -0.43
SLC2A4RG -0.40 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005179 hormone activity IEA -
GO:0005179 hormone activity TAS 9620771
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007218 neuropeptide signaling pathway IEA Neurotransmitter (GO term level: 8) -
GO:0008217 regulation of blood pressure IEA -
GO:0007267 cell-cell signaling TAS 9620771
GO:0006091 generation of precursor metabolites and energy TAS 9620771
GO:0007165 signal transduction TAS 9620771
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005625 soluble fraction TAS 9620771
GO:0030141 secretory granule IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID SYNDECAN 3 PATHWAY 17 15 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D 35 23 All SZGR 2.0 genes in this pathway
REACTOME ANDROGEN BIOSYNTHESIS 10 8 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 51 34 All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 70 50 All SZGR 2.0 genes in this pathway
REACTOME ENDOGENOUS STEROLS 15 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE HORMONE BIOSYNTHESIS 14 10 All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION 27 15 All SZGR 2.0 genes in this pathway
REACTOME STEROID HORMONES 29 21 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 127 79 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
阿布得生活信号1 46 29 All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 39 30 All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 48 31 All SZGR 2.0 genes in this pathway
MCGARVEY SILENCED BY METHYLATION IN COLON CANCER 42 29 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 72 47 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 80 50 All SZGR 2.0 genes in this pathway