Gene Page:PON1
Summary?
| GeneID | 5444 |
| Symbol | PON1 |
| Synonyms | ESA|MVCD5|PON |
| Description | paraoxonase 1 |
| Reference | MIM:168820|HGNC:HGNC:9204|HPRD:01351| |
| Gene type | protein-coding |
| Map location | 7q21.3 |
| Pascal p-value | 0.098 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | 与精神分裂症Co-occurance关键词:原理图izophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BDH1 | 0.88 | 0.91 |
| AC068580.3 | 0.87 | 0.89 |
| TAPBP | 0.87 | 0.90 |
| TUBG2 | 0.86 | 0.87 |
| CTSD | 0.86 | 0.87 |
| CEND1 | 0.86 | 0.87 |
| DHRS11 | 0.85 | 0.85 |
| C19orf66 | 0.85 | 0.87 |
| ZFYVE28 | 0.85 | 0.87 |
| PNPO | 0.85 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TUBB2B | -0.55 | -0.48 |
| RBMX2 | -0.55 | -0.58 |
| KIAA1949 | -0.55 | -0.37 |
| RPS8 | -0.54 | -0.60 |
| ZNF300 | -0.53 | -0.33 |
| TMSB15A | -0.53 | -0.53 |
| VASH2 | -0.53 | -0.31 |
| FNBP1L | -0.53 | -0.30 |
| RPL5 | -0.53 | -0.51 |
| HDAC2 | -0.53 | -0.31 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004063 | aryldialkylphosphatase activity | IEA | - | |
| GO:0004064 | arylesterase activity | NAS | 1673382 | |
| GO:0005319 | lipid transporter activity | IEA | - | |
| GO:0016787 | hydrolase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008203 | cholesterol metabolic process | IEA | - | |
| GO:0009605 | response to external stimulus | NAS | 1657140 | |
| GO:0009636 | response to toxin | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005856 | cytoskeleton | IDA | 18029348 | |
| GO:0005576 | extracellular region | NAS | 14718574 | |
| GO:0005737 | cytoplasm | IDA | 18029348 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON | 76 | 33 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT DN | 185 | 111 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER DENA DN | 74 | 45 | All SZGR 2.0 genes in this pathway |
| JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN | 43 | 31 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| KEEN RESPONSE TO ROSIGLITAZONE DN | 106 | 68 | All SZGR 2.0 genes in this pathway |
| MCDOWELL ACUTE LUNG INJURY DN | 48 | 33 | All SZGR 2.0 genes in this pathway |
| YEGNASUBRAMANIAN PROSTATE CANCER | 128 | 60 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
| LEE EARLY T LYMPHOCYTE UP | 107 | 59 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A4 | 196 | 124 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES DN | 210 | 141 | All SZGR 2.0 genes in this pathway |
| ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |