Gene Page:TOLLIP

Summary?
GeneID 54472
Symbol TOLLIP
Synonyms IL-1RAcPIP
Description toll interacting protein
Reference MIM:606277|HGNC:HGNC:16476|Ensembl:ENSG00000078902|HPRD:05887|Vega:OTTHUMG00000133333
Gene type protein-coding
Map location 11p15.5
Pascal p-value 0.09
Sherlock p-value 0.443
Fetal beta -2.343
DMG 2 (# studies)
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 5
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 5
Expression Meta-analysis of gene expression Pvalue: 1.416
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1454

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17676428 11 1314042 TOLLIP 9.13E-6 0.474 0.013 DMG:Wockner_2014
cg11259409 11 1331124 LOC255512;TOLLIP 9.04E-5 -0.225 0.027 DMG:Wockner_2014
cg03101580 11 1302893 TOLLIP 9.43E-5 0.608 0.027 DMG:Wockner_2014
cg26080154 11 1314228 TOLLIP 2.4E-4 0.38 0.037 DMG:Wockner_2014
cg13547299 11 1330611 TOLLIP -0.028 0.49 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004871 signal transducer activity NAS 11441107
GO:0005121 Toll binding NAS 11441107
GO:0005515 protein binding 新闻学会 10854325
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007267 cell-cell signaling TAS 10854325
GO:0007242 intracellular signaling cascade NAS 10854325
GO:0006955 immune response IEA -
GO:0006954 inflammatory response NAS 10854325
GO:0016310 phosphorylation IDA 1085432
GO:0045321 leukocyte activation NAS 11441107
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IC 11441107
GO:0045323 interleukin-1 receptor complex NAS 10854325
GO:0045092 interleukin-18 receptor complex NAS 10854325

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
DAZAP2 KIAA0058 | MGC14319 | MGC766 | PRTB DAZ associated protein 2 Two-hybrid BioGRID 16189514
IL1R1 CD121A | D2S1473 | IL-1R-alpha | IL1R | IL1RA | P80 interleukin 1 receptor, type I Affinity Capture-Western BioGRID 10854325
IL1RAP C3orf13 | FLJ37788 | IL-1RAcP | IL1R3 interleukin 1 receptor accessory protein - HPRD,BioGRID 10854325
IRAK1 IRAK | pelle interleukin-1 receptor-associated kinase 1 - HPRD,BioGRID 10854325
LDB1 CLIM2 | NLI LIM域绑定1 Two-hybrid BioGRID 16189514
RBPMS HERMES RNA binding protein with multiple splicing Two-hybrid BioGRID 16189514
RHOXF2 PEPP-2 | PEPP2 | THG1 Rhox homeobox family, member 2 Two-hybrid BioGRID 16189514
SEPT1 DIFF6 | LARP | MGC20394 | PNUTL3 | SEP1 septin 1 Two-hybrid BioGRID 16189514
SETDB1 ESET | KG1T | KIAA0067 | KMT1E SET domain, bifurcated 1 Two-hybrid BioGRID 16169070
TLR2 CD282 | TIL4 toll-like receptor 2 - HPRD,BioGRID 11751856
TLR4 ARMD10 | CD284 | TOLL | hToll toll-like receptor 4 - HPRD,BioGRID 11751856
TOLLIP FLJ33531 | IL-1RAcPIP toll interacting protein Reconstituted Complex BioGRID 11751856
TOM1 FLJ33404 target of myb1 (chicken) - HPRD,BioGRID 14563850
XRN2 - 5'-3' exoribonuclease 2 Two-hybrid BioGRID 15231747
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 Two-hybrid BioGRID 16169070
ZHX1 - zinc fingers and homeoboxes 1 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 27 26 All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 33 29 All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 37 31 All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 34 28 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR UP 34 22 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 97 53 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway