Gene Page:KRT20
Summary?
| GeneID | 54474 |
| Symbol | KRT20 |
| Synonyms | CD20|CK-20|CK20|K20|KRT21 |
| Description | keratin 20 |
| Reference | MIM:608218|HGNC:HGNC:20412|Ensembl:ENSG00000171431|HPRD:12193|Vega:OTTHUMG00000133366 |
| Gene type | protein-coding |
| Map location | 17q21.2 |
| Pascal p-value | 0.801 |
| TADA p-value | 0.01 |
| Fetal beta | 0.3 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| KRT20 | chr17 | 39036479 | G | A | NM_019010 | p.222T>I | missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABI2 | ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIB | abl interactor 2 | Two-hybrid | BioGRID | 16189514 |
| AMOTL2 | LCCP | angiomotin like 2 | Two-hybrid | BioGRID | 16189514 |
| ANKRD26L1 | MGC12538 | ankyrin repeat domain 26-like 1 | Two-hybrid | BioGRID | 16189514 |
| C9orf16 | EST00098 | FLJ12823 | MGC4639 | chromosome 9 open reading frame 16 | Two-hybrid | BioGRID | 16189514 |
| CCDC85B | DIPA | coiled-coil domain containing 85B | Two-hybrid | BioGRID | 16189514 |
| COASY | DPCK | FLJ35179 | NBP | PPAT | UKR1 | pOV-2 | Coenzyme A synthase | Two-hybrid | BioGRID | 16189514 |
| EIF4E2 | 4E-LP | 4EHP | EIF4EL3 | IF4e | eukaryotic translation initiation factor 4E family member 2 | Two-hybrid | BioGRID | 16189514 |
| EXOC8 | EXO84 | Exo84p | SEC84 | exocyst complex component 8 | Two-hybrid | BioGRID | 16189514 |
| FAM164C | C14orf140 | FLJ23093 | family with sequence similarity 164, member C | Two-hybrid | BioGRID | 16189514 |
| FXR2 | FMR1L2 | fragile X mental retardation, autosomal homolog 2 | Two-hybrid | BioGRID | 16189514 |
| KRT15 | CK15 | K15 | K1CO | keratin 15 | Two-hybrid | BioGRID | 16189514 |
| KRT20 | CD20 | CK20 | K20 | KRT21 | MGC35423 | keratin 20 | Two-hybrid | BioGRID | 16189514 |
| PRC1 | ASE1 | MGC1671 | MGC3669 | protein regulator of cytokinesis 1 | Two-hybrid | BioGRID | 16189514 |
| VIM | FLJ36605 | vimentin | Two-hybrid | BioGRID | 16189514 |
| ZC3H14 | FLJ11806 | MGC26892 | NY-REN-37 | UKp68 | zinc finger CCCH-type containing 14 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN | 92 | 51 | All SZGR 2.0 genes in this pathway |
| WATANABE COLON CANCER MSI VS MSS DN | 81 | 42 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
| LIU CDX2 TARGETS UP | 36 | 22 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
| STONER ESOPHAGEAL CARCINOGENESIS UP | 39 | 25 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| VANLOO SP3 TARGETS DN | 89 | 47 | All SZGR 2.0 genes in this pathway |