Gene Page:POU3F2

Summary?
GeneID 5454
Symbol POU3F2
Synonyms BRN2|N-Oct3|OCT7|OTF-7|OTF7|POUF3|brn-2|oct-7
Description POU class 3 homeobox 2
Reference MIM:600494|HGNC:HGNC:9215|Ensembl:ENSG00000184486|HPRD:02734|Vega:OTTHUMG00000015258
Gene type protein-coding
Map location 6q16
Pascal p-value 0.152
Fetal beta 2.058
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04283429 6 99280108 POU3F2 7.81E-9 -0.03 3.77E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs920513 chr1 120272605 POU3F2 5454 0.15 trans
rs10915848 chr1 225788919 POU3F2 5454 0.03 trans
rs6544404 chr2 41502544 POU3F2 5454 0.14 trans
rs1155107 chr3 26843376 POU3F2 5454 0 trans
rs9848111 chr3 26847784 POU3F2 5454 0.2 trans
rs1395163 chr3 31028951 POU3F2 5454 0.08 trans
rs17029291 chr3 32402138 POU3F2 5454 1.095E-6 trans
rs2197208 chr3 105465403 POU3F2 5454 0.2 trans
rs1553189 chr3 112939422 POU3F2 5454 0 trans
rs1807299 chr3 134470799 POU3F2 5454 0.04 trans
rs6771817 chr3 165557099 POU3F2 5454 0.1 trans
rs830202 chr3 165654796 POU3F2 5454 0.01 trans
rs4645225 chr4 126010830 POU3F2 5454 0.05 trans
rs750544 chr5 51749054 POU3F2 5454 8.811E-4 trans
rs17146240 chr5 119522933 POU3F2 5454 0.01 trans
rs17146261 chr5 119534252 POU3F2 5454 0.01 trans
rs17165234 chr5 126403634 POU3F2 5454 0.06 trans
rs2807510 chr6 73090536 POU3F2 5454 0.04 trans
rs4299797 chr6 86945707 POU3F2 5454 0.19 trans
rs9385758 chr6 136729593 POU3F2 5454 0.01 trans
rs4617108 chr7 49423831 POU3F2 5454 0.03 trans
rs3779536 chr7 127233976 POU3F2 5454 0 trans
rs4615570 chr8 13349013 POU3F2 5454 0.02 trans
rs1432030 chr8 133175445 POU3F2 5454 0.06 trans
rs17060365 chr9 77222282 POU3F2 5454 0.14 trans
rs7894597 chr10 9384581 POU3F2 5454 0.09 trans
rs11000486 chr10 74762547 POU3F2 5454 0.17 trans
rs12253630 chr10 74768923 POU3F2 5454 0.08 trans
rs7078127 chr10 74847633 POU3F2 5454 0.04 trans
rs12569493 chr10 74886042 POU3F2 5454 0 trans
rs16930362 chr10 74890320 POU3F2 5454 4.305E-4 trans
rs2271904 chr10 74894374 POU3F2 5454 0.04 trans
rs7092445 chr10 74921991 POU3F2 5454 0.01 trans
rs12256576 chr10 74934313 POU3F2 5454 0.1 trans
rs1867565 chr10 74977780 POU3F2 5454 0.11 trans
rs11000557 chr10 74987393 POU3F2 5454 0.06 trans
rs16915029 chr10 75001994 POU3F2 5454 0.01 trans
rs14488 chr10 75007274 POU3F2 5454 0.04 trans
rs16930466 chr10 75007587 POU3F2 5454 0.01 trans
rs11000579 chr10 75027961 POU3F2 5454 0.06 trans
rs2183902 chr10 75079279 POU3F2 5454 0.13 trans
rs11000607 chr10 75089777 POU3F2 5454 0 trans
rs6480700 chr10 75101689 POU3F2 5454 0.03 trans
rs16930573 chr10 75167645 POU3F2 5454 0 trans
rs12571454 chr10 75208954 POU3F2 5454 0 trans
rs17136959 chr11 78373036 POU3F2 5454 0.18 trans
rs4944213 chr11 78395188 POU3F2 5454 0.18 trans
rs17054422 chr13 37317864 POU3F2 5454 0.19 trans
rs1610001 chr13 100484419 POU3F2 5454 0.02 trans
rs1324669 chr13 107872446 POU3F2 5454 3.5E-8 trans
rs1950367 chr14 37657845 POU3F2 5454 0.2 trans
rs3742829 chr14 73489267 POU3F2 5454 0.03 trans
rs8055506 chr16 13661723 POU3F2 5454 0 trans
rs16962446 chr16 13694936 POU3F2 5454 0 trans
rs17199331 chr16 13747589 POU3F2 5454 0.03 trans
rs16958358 chr17 55502410 POU3F2 5454 4.672E-5 trans
rs16949125 chr18 45887469 POU3F2 5454 0.19 trans
rs1016438 chr19 57591037 POU3F2 5454 0.11 trans
rs16987990 chr20 41966000 POU3F2 5454 0.05 trans
rs6098023 chr20 53113740 POU3F2 5454 2.196E-4 trans
rs6015314 chr20 57167224 POU3F2 5454 0 trans
rs17145698 chrX 40218345 POU3F2 5454 0 trans
rs17328938 chrX 99519447 POU3F2 5454 0.05 trans
rs1335267 chrX 99570223 POU3F2 5454 0.05 trans
rs7065248 chrX 115510530 POU3F2 5454 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 7601453|9482665
GO:0042802 identical protein binding 新闻学会 11029584
GO:0043565 sequence-specific DNA binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0014002 astrocyte development IEA neuron, astrocyte, Glial (GO term level: 10) -
GO:0050770 regulation of axonogenesis IEA neuron, axon (GO term level: 13) -
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA -
GO:0008284 positive regulation of cell proliferation IDA 15024079
GO:0008544 epidermis development IEA -
GO:0021985 neurohypophysis development IEA -
GO:0021979 hypothalamus cell differentiation IEA -
GO:0040018 positive regulation of multicellular organism growth IEA -
GO:0045595 regulation of cell differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HBZ 41 27 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 54 37 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200 112 All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS 74 41 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN 61 39 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-128 1646 1652 1A 海关a-miR-128a UCACAGUGAACCGGUCUCUUUU
海关a-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-130/301 521 527 m8 海关a-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
海关a-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa - mir - 130 bbrain CAGUGCAAUGAUGAAAGGGCAU
海关a-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152 522 528 m8 海关a-miR-148a UCAGUGCACUACAGAACUUUGU
海关a-miR-152brain UCAGUGCAUGACAGAACUUGGG
海关a-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497 430 436 m8 海关a-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
海关a-miR-16brain UAGCAGCACGUAAAUAUUGGCG
海关a-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
海关a-miR-195SZ UAGCAGCACAGAAAUAUUGGC
海关a-miR-424 CAGCAGCAAUUCAUGUUUUGAA
海关a-miR-497 CAGCAGCACACUGUGGUUUGU
miR-19 520 526 m8 海关a-miR-19a UGUGCAAAUCUAUGCAAAACUGA
海关a-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-199 172 179 1A,m8 海关a-miR-199a CCCAGUGUUCAGACUACCUGUUC
海关a-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-204/211 1695 1702 1A,m8 海关a-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
海关a-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-218 1678 1684 1A 海关a-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-224 1923 1930 1A,m8 海关a-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-27 1646 1652 m8 海关a-miR-27abrain UUCACAGUGGCUAAGUUCCGC
海关a-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-320 2404 2410 1A 海关a-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-378 825 831 1A 海关a-miR-378 CUCCUGACUCCAGGUCCUGUGU
海关a-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-410 2528 2534 1A 海关a-miR-410 AAUAUAACACAGAUGGCCUGU
miR-494 1890 1896 1A 海关a-miR-494brain UGAAACAUACACGGGAAACCUCUU
海关a-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-495 1517 1523 1A 海关a-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-542-3p 1975 1981 1A 海关a-miR-542-3p UGUGACAGAUUGAUAACUGAAA
miR-544 2256 2263 1A,m8 海关a-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 777 783 m8 海关a-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA