Gene Page:UGT1A1
Summary?
| GeneID | 54658 |
| Symbol | UGT1A1 |
| Synonyms | BILIQTL1|GNT1|HUG-BR1|UDPGT|UDPGT 1-1|UGT1|UGT1A |
| Description | UDP glucuronosyltransferase family 1 member A1 |
| Reference | MIM:191740|HGNC:HGNC:12530|运用:ENSG00000241635|HPRD:08933|Vega:OTTHUMG00000059117 |
| Gene type | protein-coding |
| Map location | 2q37 |
| Pascal p-value | 0.639 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 0 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS | 28 | 17 | All SZGR 2.0 genes in this pathway |
| KEGG ASCORBATE AND ALDARATE METABOLISM | 25 | 17 | All SZGR 2.0 genes in this pathway |
| KEGG STEROID HORMONE BIOSYNTHESIS | 55 | 30 | All SZGR 2.0 genes in this pathway |
| KEGG STARCH AND SUCROSE METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| KEGG RETINOL METABOLISM | 64 | 37 | All SZGR 2.0 genes in this pathway |
| KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM | 41 | 23 | All SZGR 2.0 genes in this pathway |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM OTHER ENZYMES | 51 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCURONIDATION | 18 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE II CONJUGATION | 70 | 42 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PORPHYRINS | 14 | 7 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| TAKAYAMA BOUND BY AR | 10 | 6 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS LCP WITH H3K27ME3 | 10 | 7 | All SZGR 2.0 genes in this pathway |
| DANG REGULATED BY MYC DN | 253 | 192 | All SZGR 2.0 genes in this pathway |
| SERVITJA ISLET HNF1A TARGETS DN | 109 | 71 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |