SZGR2 - Beplay体育中心

Summary?

GeneID	5468
Symbol	PPARG
Synonyms	CIMT1\|GLM1\|NR1C3\|PPARG1\|PPARG2\|PPARgamma
Description	peroxisome proliferator activated receptor gamma
Reference	MIM:601487\|HGNC:HGNC:9236\|Ensembl:ENSG00000132170\|HPRD:03288\|Vega:OTTHUMG00000129764
Gene type	protein-coding
Map location	3p25
Pascal p-value	0.006
Sherlock p-value	0.6
Fetal beta	-0.921
eGene	Cerebellar Hemisphere Cerebellum Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Literature	High-throughput literature-search	与精神分裂症Co-occurance keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs633915	chr1	182682157	PPARG	5468		0.09		trans
rs621071	chr1	182682810	PPARG	5468		0.07		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CMPK1	0.94	0.94
ATAD1	0.93	0.93
CNOT7	0.93	0.93
TTC33	0.93	0.94
SLC30A9	0.92	0.92
HSPA13	0.92	0.93
TBC1D23	0.92	0.90
STX12	0.92	0.93
RHOT1	0.92	0.91
USP33	0.92	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.67	-0.68
MT-CO2	-0.67	-0.66
AF347015.33	-0.64	-0.64
AF347015.21	-0.64	-0.60
AF347015.8	-0.64	-0.65
AF347015.2	-0.63	-0.62
AC018755.7	-0.63	-0.67
MT-CYB	-0.63	-0.63
HIGD1B	-0.63	-0.63
AF347015.31	-0.63	-0.63

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
走:0004872	receptor activity	IEA		-
走:0004879	ligand-dependent nuclear receptor activity	IEA		-
走:0003700	transcription factor activity	IEA		-
走:0003707	steroid hormone receptor activity	IEA		-
走:0005515	protein binding	IEA		-
走:0004955	prostaglandin receptor activity	TAS		9568715
走:0008270	zinc ion binding	IEA		-
走:0008144	药物绑定	IDA		9113987\|10622252
走:0016564	transcription repressor activity	IEA		-
走:0016563	transcription activator activity	IEA		-
走:0033613	transcription activator binding	IDA		10622252
走:0046872	metal ion binding	IEA		-
走:0046965	retinoid X receptor binding	IDA		9568715
走:0046982	protein heterodimerization activity	TAS		9744270
走:0043565	sequence-specific DNA binding	IEA		-
走:0050544	arachidonic acid binding	ISS		9568715
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
走:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA		-
走:0001890	placenta development	ISS		-
走:0006355	regulation of transcription, DNA-dependent	IEA		-
去:0030224	monocyte differentiation	IDA		9568716
走:0042953	lipoprotein transport	IDA		9568716
走:0006350	transcription	IEA		-
走:0008217	regulation of blood pressure	IMP		10622252
走:0007165	signal transduction	IDA		9568716
走:0048469	cell maturation	IDA		9568716
走:0007584	response to nutrient	TAS		10973253
走:0006629	lipid metabolic process	TAS		9568716
走:0015909	long-chain fatty acid transport	ISS		-
走:0030855	epithelial cell differentiation	IEA		-
走:0033993	response to lipid	ISS		9568715
走:0042593	glucose homeostasis	IMP		10622252
走:0050872	white fat cell differentiation	IEA		-
走:0050872	white fat cell differentiation	TAS		12588810
走:0032869	cellular response to insulin stimulus	IMP		10622252
走:0045165	cell fate commitment	IEA		-
走:0045600	positive regulation of fat cell differentiation	IEA		-
走:0045600	positive regulation of fat cell differentiation	ISS		-
走:0045941	positive regulation of transcription	IEA		-
走:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
走:0045087	innate immune response	TAS		17145956
走:0045713	low-density lipoprotein receptor biosynthetic process	IDA		9568716
走:0055088	lipid homeostasis	TAS		9113987
走:0055098	response to low density lipoprotein stimulus	IDA		9568716
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
走:0005829	cytosol	IEA		-
走:0005634	nucleus	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCAS2	DAM1	breast carcinoma amplified sequence 2	BCAS2 interacts with PPAR-gamma. This interaction was modeled on a demonstrated interaction between human BCAS2 and PPAR-gamma from an unspecified species.	BIND	15694360
BRD8	SMAP \| SMAP2 \| p120	bromodomain containing 8	-	HPRD	10517671
CEP350	CAP350 \| FLJ38282 \| FLJ44058 \| GM133 \| KIAA0480	centrosomal protein 350kDa	CAP350 interacts with PPAR-gamma-2.	BIND	15615782
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Reconstituted Complex	BioGRID	10848596
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	deoxynucleotidyltransferase, terminal, interacting protein 2	-	HPRD,BioGRID	1504714
DUT	FLJ20622 \| dUTPase	deoxyuridine triphosphatase	-	HPRD	8910358
EDF1	EDF-1 \| MBF1 \| MGC9058	endothelial differentiation-related factor 1	-	HPRD,BioGRID	12040021
EP300	KAT3B \| p300	E1A binding protein p300	Reconstituted Complex Two-hybrid	BioGRID	10944516\|12479814
FABP1	FABPL \| L-FABP	fatty acid binding protein 1, liver	-	HPRD,BioGRID	11226238
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	-	HPRD	10872826
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10872826
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	-	HPRD,BioGRID	12479814
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Reconstituted Complex	BioGRID	12943985
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	12037571
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	Reconstituted Complex Two-hybrid	BioGRID	10944516
MED24	ARC100 \| CRSP100 \| CRSP4 \| DRIP100 \| KIAA0130 \| MGC8748 \| THRAP4 \| TRAP100	中介复杂的亚基24	-	HPRD,BioGRID	9653119
MPG	AAG \| APNG \| CRA36.1 \| MDG \| Mid1 \| PIG11 \| PIG16 \| anpg	N-methylpurine-DNA glycosylase	MPG interacts with an unspecified isoform of PPARG (PPAR-gamma). This interaction was modeled on a demonstrated interaction between MPG from an unspecified species and PPARG from an unspecified species.	BIND	14761960
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	9041124\|10848596 \|11330046
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD,BioGRID	10944516
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	Reconstituted Complex Two-hybrid	BioGRID	10944516
NCOA4	ARA70 \| DKFZp762E1112 \| ELE1 \| PTC3 \| RFG	nuclear receptor coactivator 4	-	HPRD,BioGRID	10347167
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	-	HPRD	10788465
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Two-hybrid	BioGRID	11158331
NFE2L2	NRF2	nuclear factor (erythroid-derived 2)-like 2	-	HPRD,BioGRID	10930400
NR0B2	FLJ17090 \| SHP \| SHP1	nuclear receptor subfamily 0, group B, member 2	-	HPRD,BioGRID	11696534
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD,BioGRID	9626662
POU1F1	GHF-1 \| PIT1 \| Pit-1	POU class 1 homeobox 1	Reconstituted Complex	BioGRID	11891224
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD	11831892
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	-	HPRD	12502716
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Reconstituted Complex	BioGRID	14636573
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2 interacts with PPAR-gamma.	BIND	12039952
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western Reconstituted Complex	BioGRID	12479814
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	-	HPRD,BioGRID	7838715\|10854698
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	-	HPRD	7838715\|10854698 \|10882139
RXRG	NR2B3 \| RXRC	retinoid X receptor, gamma	-	HPRD	12615696
SVIL	DKFZp686A17191	supervillin	Two-hybrid	BioGRID	11792840

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PPAR SIGNALING PATHWAY	69	47	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA NUCLEARRS PATHWAY	15	12	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY	47	39	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID RXR VDR PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	49	36	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP	149	84	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 2	42	31	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DN NUYTTEN EZH2目标	1024	594	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP	266	171	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP	114	84	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP	89	61	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP	131	87	All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE	33	22	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN	50	32	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP	74	51	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE DN	42	24	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN	84	50	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5	126	78	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP	43	33	All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP	84	55	All SZGR 2.0 genes in this pathway
LI ADIPOGENESIS BY ACTIVATED PPARG	17	12	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP	49	40	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP	84	52	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN	78	49	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
PARK TRETINOIN RESPONSE AND RARA PLZF FUSION	22	14	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP	89	61	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
NAKAYAMA软组织肿瘤PCA2 DN	80	51	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
GERHOLD RESPONSE TO TZD DN	13	11	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TROGLITAZONE DN	19	14	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN	88	61	All SZGR 2.0 genes in this pathway
STEGER ADIPOGENESIS UP	21	16	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4	110	66	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK	145	82	All SZGR 2.0 genes in this pathway
VERNOCHET ADIPOGENESIS	19	11	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	82	88	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	82	88	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	42	49	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-27	82	89	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	82	89	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

Gene Page:PPARG