Gene Page:MED1
Summary?
| GeneID | 5469 |
| Symbol | MED1 |
| Synonyms | CRSP1|CRSP200|DRIP205|DRIP230|PBP|PPARBP|PPARGBP|RB18A|TRAP220|TRIP2 |
| Description | mediator complex subunit 1 |
| Reference | MIM:604311|HGNC:HGNC:9234|Ensembl:ENSG00000125686|HPRD:05055|Vega:OTTHUMG00000133216 |
| Gene type | protein-coding |
| Map location | 17q12 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.36 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | 全基因组的sociation Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SKIV2L2 | 0.95 | 0.93 |
| SMNDC1 | 0.93 | 0.92 |
| UBA2 | 0.93 | 0.93 |
| QRSL1 | 0.93 | 0.90 |
| COPB1 | 0.93 | 0.94 |
| DHX15 | 0.93 | 0.93 |
| XPO1 | 0.92 | 0.93 |
| NCK1 | 0.92 | 0.87 |
| CEBPZ | 0.92 | 0.92 |
| ZNF271 | 0.92 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.67 | -0.82 |
| FXYD1 | -0.65 | -0.82 |
| AF347015.33 | -0.65 | -0.80 |
| AF347015.31 | -0.64 | -0.79 |
| AF347015.27 | -0.64 | -0.79 |
| AF347015.8 | -0.64 | -0.81 |
| MT-CYB | -0.64 | -0.79 |
| IFI27 | -0.62 | -0.78 |
| HLA-F | -0.62 | -0.74 |
| AF347015.2 | -0.62 | -0.81 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | - | HPRD,BioGRID | 12218053 |
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | BRCA1 interacts with TRAP220. | BIND | 15208681 |
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex |
BioGRID | 15208681 |
| CDK8 | K35 | MGC126074 | MGC126075 | cyclin-dependent kinase 8 | Affinity Capture-MS | BioGRID | 10198638 |
| CDKN1A | CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | MED1 interacts with p21 promoter. | BIND | 15989967 |
| CTSD | CLN10 | CPSD | MGC2311 | cathepsin D | MED1 interacts with Cathepsin-D promoter. | BIND | 15989967 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | ESR1 (ER-alpha) interacts with PPARBP (TRAP220). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and PPARBP from an unspecified species. | BIND | 12738788 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | Affinity Capture-Western | BioGRID | 12837248 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | - | HPRD | 9653119 |
| ESR2 | ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 | estrogen receptor 2 (ER beta) | - | HPRD,BioGRID | 11867769 |
| HNF4A | FLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14 | hepatocyte nuclear factor 4, alpha | - | HPRD,BioGRID | 12089346 |
| MED1 | CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2 | mediator complex subunit 1 | - | HPRD,BioGRID | 9444950 |
| MED10 | L6 | MGC5309 | NUT2 | TRG20 | mediator complex subunit 10 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 14638676|15175163 |
| MED19 | DT2P1G7 | LCMR1 | mediator complex subunit 19 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 14638676|15175163 |
| MED24 | ARC100 | CRSP100 | CRSP4 | DRIP100 | KIAA0130 | MGC8748 | THRAP4 | TRAP100 | mediator complex subunit 24 | Co-purification | BioGRID | 9653119 |
| MED25 | ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758 | mediator complex subunit 25 | Affinity Capture-Western | BioGRID | 14638676 |
| MED25 | ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758 | mediator complex subunit 25 | - | HPRD | 14983011 |
| MED26 | CRSP7 | CRSP70 | mediator complex subunit 26 | Affinity Capture-MS | BioGRID | 15175163 |
| MED28 | 1500003D12Rik | DKFZp434N185 | EG1 | magicin | mediator complex subunit 28 | Affinity Capture-MS | BioGRID | 15175163 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | - | HPRD | 14576168 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 14638676|15175163 |
| MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | - | HPRD | 14638676 |
| MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | Affinity Capture-MS | BioGRID | 15175163 |
| NR1I3 | CAR | CAR1 | MB67 | MGC150433 | MGC97144 | MGC97209 | nuclear receptor subfamily 1, group I, member 3 | CAR interacts with TRAP. | BIND | 15572376 |
| NR3C1 | GCCR | GCR | GR | GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Reconstituted Complex | BioGRID | 10508170|11266503 |
| NR4A1 | GFRP1 | HMR | MGC9485 | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3 | nuclear receptor subfamily 4, group A, member 1 | - | HPRD | 12082103 |
| PPARA | MGC2237 | MGC2452 | NR1C1 | PPAR | hPPAR | peroxisome proliferator-activated receptor alpha | - | HPRD | 9653119 |
| PPARG | NR1C3 | PPARG1 | PPARG2 | PPARgamma | peroxisome proliferator-activated receptor gamma | - | HPRD | 12037571 |
| PPARG | NR1C3 | PPARG1 | PPARG2 | PPARgamma | peroxisome proliferator-activated receptor gamma | Reconstituted Complex Two-hybrid |
BioGRID | 10944516 |
| PPARGC1A | LEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | - | HPRD,BioGRID | 14636573 |
| RORA | DKFZp686M2414 | MGC119326 | MGC119329 | NR1F1 | ROR1 | ROR2 | ROR3 | RZR-ALPHA | RZRA | RAR-related orphan receptor A | - | HPRD | 10478845 |
| RXRA | FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 | retinoid X receptor, alpha | - | HPRD | 9653119 |
| TFF1 | BCEI | D21S21 | HP1.A | HPS2 | pNR-2 | pS2 | trefoil factor 1 | MED1 interacts with pS2 promoter. | BIND | 15989967 |
| TGS1 | DKFZp762A163 | FLJ22995 | NCOA6IP | PIMT | PIPMT | trimethylguanosine synthase homolog (S. cerevisiae) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11912212 |
| THRA | AR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1 | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | - | HPRD,BioGRID | 9653119 |
| THRAP3 | FLJ22082 | MGC133082 | MGC133083 | TRAP150 | thyroid hormone receptor associated protein 3 | Co-purification | BioGRID | 9653119 |
| THRB | ERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | - | HPRD | 9325263 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | - | HPRD,BioGRID | 9444950|11118038 |
| VDR | NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 10198638|12837248 |
| VDR | NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor | - | HPRD | 9653119 |
| YWHAH | YWHA1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | - | HPRD | 11266503 |
| YWHAQ | 14-3-3 | 1C5 | HS1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | Reconstituted Complex | BioGRID | 11266503 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA CARM ER PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
| BIOCARTA VDR PATHWAY | 12 | 7 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PPARA PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PITX2 PATHWAY | 15 | 15 | All SZGR 2.0 genes in this pathway |
| PID AR PATHWAY | 61 | 46 | All SZGR 2.0 genes in this pathway |
| PID RXR VDR PATHWAY | 26 | 24 | All SZGR 2.0 genes in this pathway |
| PID ERA GENOMIC PATHWAY | 65 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME BMAL1时钟NPAS2激活生理实验RESSION | 36 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 24 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 24 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 23 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
| REACTOME CIRCADIAN CLOCK | 53 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS UP | 135 | 82 | All SZGR 2.0 genes in this pathway |
| CHIN BREAST CANCER COPY NUMBER UP | 27 | 18 | All SZGR 2.0 genes in this pathway |
| KONG E2F3 TARGETS | 97 | 58 | All SZGR 2.0 genes in this pathway |
| AUNG GASTRIC CANCER | 54 | 20 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER CLUSTER 8 | 7 | 7 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS | 128 | 77 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS | 65 | 38 | All SZGR 2.0 genes in this pathway |
| GUO HEX TARGETS DN | 65 | 36 | All SZGR 2.0 genes in this pathway |
| JAIN NFKB SIGNALING | 75 | 44 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN | 33 | 21 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR UP | 156 | 101 | All SZGR 2.0 genes in this pathway |
| URS ADIPOCYTE DIFFERENTIATION DN | 30 | 20 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER ERBB2 UP | 147 | 83 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | 188 | 121 | All SZGR 2.0 genes in this pathway |
| YOSHIOKA LIVER CANCER EARLY RECURRENCE UP | 40 | 23 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |