Gene Page:RBFOX1

概括?
基因 54715
Symbol RBFOX1
Synonyms 2BP1|A2BP1|FOX-1|FOX1|HRNBP1
Description RNA binding protein, fox-1 homolog (C. elegans) 1
Reference MIM:605104|HGNC:HGNC:18222|Ensembl:ENSG00000078328|HPRD:16091|Vega:OTTHUMG00000129551
Gene type protein-coding
Map location 16p13.3
Sherlock p-value 0.415
Fetal beta 0.891
DMG 1 (# studies)
eGene Myers' cis & trans
元
Support Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00470955 16 7354432 RBFOX1 1.02E-7 -0.008 2.25E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6497287 chr15 28440286 RBFOX1 54715 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003723 RNA binding NAS 10814712
GO:0008022 protein C-terminus binding 新闻学会 10814712
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0006397 mRNA processing IEA -
GO:0008380 RNA splicing IEA -
GO:0050658 RNA transport NAS 10814712
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005802 trans-Golgi network IDA 10814712
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IDA 10814712

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 该途径中的所有SZGR 2.0基因
TAKADA GASTRIC CANCER COPY NUMBER DN 29 15 该途径中的所有SZGR 2.0基因
XU GH1 AUTOCRINE TARGETS UP 268 157 该途径中的所有SZGR 2.0基因
XU GH1 AUTOCRINE TARGETS DN 142 94 该途径中的所有SZGR 2.0基因
CAMPS COLON CANCER COPY NUMBER DN 74 34 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228 114 该途径中的所有SZGR 2.0基因
阿塞维多在肝脏通过甲基化R DN 940 425 该途径中的所有SZGR 2.0基因
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 该途径中的所有SZGR 2.0基因
IKEDA MIR1 TARGETS DN 7 7 该途径中的所有SZGR 2.0基因
IKEDA MIR30 TARGETS DN 27 24 该途径中的所有SZGR 2.0基因
SERVITJA ISLET HNF1A TARGETS UP 163 111 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 TARGETS 10HR UP 199 143 该途径中的所有SZGR 2.0基因
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 该途径中的所有SZGR 2.0基因
ZWANG EGF PERSISTENTLY UP 32 24 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 154 160 1A hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-1/206 661 667 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-129-5p 870 876 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-132/212 1003 1009 1A hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-186 897 903 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-217 72 79 1A,m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-27 1596 1602 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-299-5p 1723 1729 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-30-5p 1422 1429 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-320 1674 1680 m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-328 290 296 m8 hsa-miR-328brain CUGGCCCUCUCUGCCCUUCCGU
hsa-miR-328brain CUGGCCCUCUCUGCCCUUCCGU
mir-496 315 321 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-7 1460 1466 m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG