Gene Page:FAM20A
Summary?
| GeneID | 54757 |
| Symbol | FAM20A |
| Synonyms | AI1G|AIGFS|FP2747 |
| Description | family with sequence similarity 20 member A |
| Reference | MIM:611062|HGNC:HGNC:23015|Ensembl:ENSG00000108950|HPRD:13296| |
| Gene type | protein-coding |
| Map location | 17q24.2 |
| Pascal p-value | 0.081 |
| Fetal beta | 0.855 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FAM20A | chr17 | 66538296 | C | T | NM_001243746 NM_001276290 NM_017565 NR_027751 |
. . . . |
silent intronic silent npcRNA |
Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1531089 | chr1 | 219542971 | FAM20A | 54757 | 0.09 | trans | ||
| rs1566993 | chr2 | 117105059 | FAM20A | 54757 | 0.15 | trans | ||
| rs11893837 | chr2 | 127494318 | FAM20A | 54757 | 0.05 | trans | ||
| rs17077856 | chr3 | 45504326 | FAM20A | 54757 | 0.1 | trans | ||
| rs1353401 | chr4 | 59902753 | FAM20A | 54757 | 0.06 | trans | ||
| snp_a-2158715 | 0 | FAM20A | 54757 | 0.06 | trans | |||
| rs17381134 | chr4 | 157179855 | FAM20A | 54757 | 0.05 | trans | ||
| rs10050805 | chr5 | 30805352 | FAM20A | 54757 | 0.16 | trans | ||
| rs9381511 | chr6 | 12931447 | FAM20A | 54757 | 0.07 | trans | ||
| rs6455226 | chr6 | 67930295 | FAM20A | 54757 | 0.03 | trans | ||
| rs1159612 | chr10 | 85329057 | FAM20A | 54757 | 0.01 | trans | ||
| rs10879027 | chr12 | 70237156 | FAM20A | 54757 | 0.08 | trans | ||
| rs10492030 | chr12 | 113460334 | FAM20A | 54757 | 0.04 | trans | ||
| rs10781905 | chr13 | 24993573 | FAM20A | 54757 | 0.17 | trans | ||
| rs1216717 | chr13 | 46871963 | FAM20A | 54757 | 0.06 | trans | ||
| rs16956620 | chr15 | 31496513 | FAM20A | 54757 | 0.11 | trans | ||
| rs16958302 | chr16 | 57647432 | FAM20A | 54757 | 0.03 | trans | ||
| rs6095741 | chr20 | 48666589 | FAM20A | 54757 | 0 | trans | ||
| rs5915713 | chrX | 4077883 | FAM20A | 54757 | 6.512E-4 | trans | ||
| rs5991662 | chrX | 43335796 | FAM20A | 54757 | 0.15 | trans | ||
| rs1545676 | chrX | 93530472 | FAM20A | 54757 | 3.534E-4 | trans | ||
| rs242163 | chrX | 132311662 | FAM20A | 54757 | 0.01 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP | 205 | 140 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN | 463 | 290 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS C UP | 170 | 114 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT DN | 129 | 86 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P2 | 79 | 55 | All SZGR 2.0 genes in this pathway |
| RAY TUMORIGENESIS BY ERBB2 CDC25A DN | 159 | 105 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 DN | 240 | 153 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| BOSCO TH1 CYTOTOXIC MODULE | 114 | 62 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |
| GHANDHI DIRECT IRRADIATION UP | 110 | 68 | All SZGR 2.0 genes in this pathway |
| NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |