Gene Page:FAM46C

概括?
基因 54855
象征 FAM46C
Synonyms -
Description family with sequence similarity 46 member C
Reference MIM:613952|HGNC:HGNC:24712|Ensembl：ENSG00000183508|HPRD:13312|Vega:OTTHUMG00000013703
Gene type protein-coding
Map location 1p12
Pascal p-value 0.157
Fetal beta 0.303
DMG 2 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 2
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
CG25767870 1 118188756 FAM46C 2.69E-4 0.006 0.173 DMG:Montano_2016
CG13482356 1 118148519 FAM46C 2.28E-10 -0.022 5.98E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOOI ST7 TARGETS DN 123 78 该途径中的所有SZGR 2.0基因
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 该途径中的所有SZGR 2.0基因
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 该途径中的所有SZGR 2.0基因
vecchi胃癌早期DN 367 220 该途径中的所有SZGR 2.0基因
ODONNELL TFRC TARGETS UP 456 228 该途径中的所有SZGR 2.0基因
ODONNELL TARGETS OF MYC AND TFRC UP 83 50 该途径中的所有SZGR 2.0基因
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 该途径中的所有SZGR 2.0基因
WONG ENDOMETRIAL CANCER LATE 10 5 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 该途径中的所有SZGR 2.0基因
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 87 48 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
MORI PLASMA CELL UP 51 29 该途径中的所有SZGR 2.0基因
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES UP 253 147 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 该途径中的所有SZGR 2.0基因
ZHENG BOUND BY FOXP3 491 310 该途径中的所有SZGR 2.0基因
ZHENG FOXP3 TARGETS UP 26 16 该途径中的所有SZGR 2.0基因
FOSTER TOLERANT MACROPHAGE UP 156 92 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA C D DN 252 155 该途径中的所有SZGR 2.0基因
VANASSE BCL2 TARGETS UP 40 25 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS DN 435 289 该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 该途径中的所有SZGR 2.0基因
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN 9 7 该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE DN 841 431 该途径中的所有SZGR 2.0基因
CHICAS RB1 TARGETS CONFLUENT 567 365 该途径中的所有SZGR 2.0基因
Wang对GSK3抑制剂SB216763 DN的响应 374 217 该途径中的所有SZGR 2.0基因
Dutertre雌二醇反应24小时 324 193 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS UP 504 321 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 33 25 该途径中的所有SZGR 2.0基因
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 26 15 该途径中的所有SZGR 2.0基因
HOLLEMAN ASPARAGINASE RESISTANCE ALL UP 22 14 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-141/200a 1364 1371 1A,m8 hsa-miR-141 uaacacugucugugugugugaugg
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
miR-17-5p/20/93.mr/106/519.d 1347 1354 1A,m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-19 2045 2052 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-24 175 181 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-26 712 718 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-299-5p 583 589 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-30-5p 3848 3854 m8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-384 791 797 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-409-5p 2539 2545 m8 hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-9 586 592 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520 2108 2114 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU