Gene Page:WHSC1L1

Summary?
GeneID 54904
Symbol WHSC1L1
Synonyms NSD3|WHISTLE|pp14328
Description Wolf-Hirschhorn syndrome candidate 1-like 1
Reference MIM:607083|HGNC: HGNC: 12767|Ensembl:ENSG00000147548|HPRD:06155|织女:OTTHUMG00000165115
Gene type protein-coding
Map location 8p11.2
Pascal p-value 1.364E-6
Sherlock p-value 0.478
Fetal beta 1.558
DMG 1 (# studies)
Support Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01609705 8 38240669 WHSC1L1 4.25E-9 -0.006 2.55E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C11orf59 0.90 0.82
COX8A 0.90 0.81
MPG 0.89 0.76
C17orf90 0.89 0.77
ZNF593 0.87 0.70
MRP63 0.86 0.76
NDUFA7 0.86 0.63
SIVA1 0.85 0.76
ISOC2 0.85 0.74
MRPL55 0.85 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF5B -0.39 -0.46
RBM25 -0.38 -0.35
ZNHIT6 -0.37 -0.28
AC010300.1 -0.37 -0.50
ZNF326 -0.36 -0.31
CCDC55 -0.36 -0.28
AC005921.3 -0.34 -0.47
Z83840.4 -0.34 -0.32
AF347015.18 -0.34 -0.30
SFRS12 -0.33 -0.27

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG LYSINE DEGRADATION 44 29 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 9 8 6 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 57 32 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210 128 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP 116 65 All SZGR 2.0 genes in this pathway