Gene Page:EXD3
Summary?
| GeneID | 54932 |
| Symbol | EXD3 |
| Synonyms | mut-7 |
| Description | exonuclease 3'-5' domain containing 3 |
| Reference | HGNC:HGNC:26023|Ensembl:ENSG00000187609|HPRD:07906|Vega:OTTHUMG00000156149 |
| Gene type | protein-coding |
| Map location | 9q34.3 |
| Pascal p-value | 0.3 |
| Sherlock p-value | 9.269E-4 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
| 支持 | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| 认为:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
认为table
认为table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EXD3 | chr9 | 140267493 | C | T | NM_017820 | p.109R>Q | missense | Schizophrenia | 认为:Fromer_2014 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg21242417 | 9 | 140263615 | EXD3 | 3.265E-4 | 0.281 | 0.04 | DMG:Wockner_2014 |
| cg11790438 | 9 | 140317161 | NOXA1;EXD3 | 5.571E-4 | -0.224 | 0.049 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16853302 | chr1 | 178686330 | EXD3 | 54932 | 0.2 | trans | ||
| rs4449188 | chr2 | 100549336 | EXD3 | 54932 | 0.07 | trans | ||
| rs10274590 | chr7 | 49365101 | EXD3 | 54932 | 0.19 | trans | ||
| rs2171076 | chr7 | 68550015 | EXD3 | 54932 | 0 | trans | ||
| rs6530873 | chr8 | 15342889 | EXD3 | 54932 | 0.05 | trans | ||
| rs11002835 | chr10 | 80880899 | EXD3 | 54932 | 0.17 | trans | ||
| rs10837895 | chr11 | 42692512 | EXD3 | 54932 | 0.17 | trans | ||
| rs3743707 | chr16 | 59785925 | EXD3 | 54932 | 0.12 | trans | ||
| rs3743706 | chr16 | 59786019 | EXD3 | 54932 | 0.12 | trans | ||
| rs7240399 | chr18 | 55673549 | EXD3 | 54932 | 0.13 | trans | ||
| rs8083456 | chr18 | 55675432 | EXD3 | 54932 | 0.13 | trans | ||
| rs17276168 | chr18 | 68845841 | EXD3 | 54932 | 7.789的军医 | trans | ||
| rs7238314 | chr18 | 68929158 | EXD3 | 54932 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG CLIM2 TARGETS UP | 269 | 146 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |
| ZWANG EGF INTERVAL UP | 105 | 46 | All SZGR 2.0 genes in this pathway |