Gene Page:HERC6

Summary?
GeneID 55008
Symbol HERC6
Synonyms -
Description HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Reference MIM:609249|HGNC:HGNC:26072|Ensembl:ENSG00000138642|Ensembl:ENSG00000246375|HPRD:13647|织女:OTTHUMG00000160983
Gene type protein-coding
Map location 4q22.1
Pascal p-value 0.207
Fetal beta -0.623

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SNRNP70 0.89 0.89
PABPN1 0.85 0.81
B4GALNT4 0.85 0.83
CCDC12 0.85 0.83
ZBTB48 0.84 0.80
PRKRIP1 0.84 0.79
STX10 0.84 0.74
DNAJC17 0.84 0.80
BAX 0.84 0.83
LUC7L 0.84 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.60 -0.72
AF347015.27 -0.57 -0.69
MT-CYB -0.56 -0.69
MT-CO2 -0.56 -0.67
C5orf53 -0.56 -0.60
AF347015.33 -0.56 -0.68
B2M -0.54 -0.63
AF347015.8 -0.53 -0.68
AF347015.15 -0.53 -0.69
AF347015.9 -0.53 -0.69

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 157 91 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 44 23 All SZGR 2.0 genes in this pathway
多尔STAT3 DN的目标 50 34 All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 73 47 All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 UP 74 32 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ROETH TERT TARGETS UP 14 11 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 74 50 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 95 54 All SZGR 2.0 genes in this pathway