Gene Page:ppp1cc

Summary？
基因 5501
象征 ppp1cc
Synonyms pp-1g | pp1c | ppp1g
Description 蛋白质磷酸酶1催化亚基伽玛
Reference MIM:176914|HGNC：HGNC：9283|Ensembl:ENSG00000186298|HPRD：08911|Vega：Otthumg00000169531
基因类型 蛋白质编码
Map location 12q24.1-q24.2
Pascal p-value 5.654e-4
Sherlock p-value 0.854
Support G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS
G2CDB.HUMANNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
染色质重塑基因
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
STMN2 0.95 0.97
STMN1 0.93 0.95
CDC42 0.91 0.94
PWP1 0.91 0.92
arl8a 0.91 0.92
NT5C3 0.91 0.92
ARMCX1 0.90 0.94
ARMCX5 0.90 0.92
TTLL1 0.90 0.92
mllt11 0.90 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
AF347015.33 -0.81 -0.88
MT-CO2 -0.80 -0.87
AF347015.31 -0.80 -0.86
AF347015.27 -0.79 -0.86
HEPN1 -0.79 -0.83
HLA-F -0.79 -0.82
mt-cyb -0.78 -0.86
TSC22D4 -0.78 -0.85
AF347015.8 -0.77 -0.87
FXYD1 -0.77 -0.85

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005506 铁离子结合 IEA -
去：0005515 蛋白质结合 IPI 17274640|17511879
GO:0004721 phosphoprotein phosphatase activity IEA -
GO：0016787 水解酶活性 IEA -
GO：0030145 锰离子结合 IEA -
GO：0046872 metal ion binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0005977 glycogen metabolic process IEA -
去：0005975 碳水化合物代谢过程 IEA -
GO:0007049 cell cycle IEA -
去：0051301 细胞分裂 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IEA -
去：0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
AKAP11 AKAP220 |DKFZP781I12161 |FLJ11304 |KIAA0629 |PRKA11 激酶（PRKA）锚蛋白11 亲和力捕获 - 韦斯特恩 Biogrid 12147701
myo16 KIAA0865 | MYR8 | Myo16b myosin XVI - HPRD 11588169
polr2a MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa ppp1cc(TAPP) interacts with and dephosphorylates POLR2A (RNAPII). This interaction was modelled on a demonstrated interaction between human PPP1CC and POLR2A from an unspecified species. 绑定 12036313
PPP1R15A GADD34 蛋白质磷酸酶1，调节（抑制剂）亚基15A 亲和力捕获 - 韦斯特恩
表型抑制		 Biogrid 11564868|12016208
PPP1R2 ipp2 |MGC87148 蛋白质磷酸酶1，调节（抑制剂）亚基2 体外 Biogrid 10807923
PPP1R3D DKFZp781L2441 | PPP1R6 protein phosphatase 1, regulatory (inhibitor) subunit 3D 重构的复合物 Biogrid 9414128
PPP1R8 ard-1 |ard1 |nipp-1 |nipp1 |Pro2047 蛋白质磷酸酶1，调节（抑制剂）亚基8 重构的复合物 Biogrid 11104670
PPP1R9B FLJ30345 |PPP1R6 |PPP1R9 |Spino |SPN protein phosphatase 1, regulatory (inhibitor) subunit 9B 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 10194355|10391935
RYR2 arvc2 |arvd2 |VTSIP ryanodine receptor 2 (cardiac) 共同分级 Biogrid 10830164
Smarcb1 BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 亲和力捕获 - 韦斯特恩
表型增强
重构的复合物		 Biogrid 12016208
TLX1 HOX11 |MGC163402 |TCL3 T-cell leukemia homeobox 1 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 9009195
TP53BP2 53bp2 |aspp2 |BBP |ppp1r13a |p53bp2 tumor protein p53 binding protein, 2 - HPRD 8549741
WBP11 DKFZp779M1063 | NPWBP | SIPP1 WW domain binding protein 11 - HPRD 14640981


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Kegg卵母细胞减数分裂 114 79 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
PID AURORA B PATHWAY 39 24 All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 26 24 All SZGR 2.0 genes in this pathway
反应组细胞周期 421 253 All SZGR 2.0 genes in this pathway
TGFβ受体信号的反应组下调 23 13 All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 26 16 All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC 325 185 All SZGR 2.0 genes in this pathway
Reactome有丝分裂M M G1相 172 98 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
Reactome DNA复制 192 110 All SZGR 2.0 genes in this pathway
反应组激素敏感脂肪酶HSL介导的三酰基甘油水解 13 11 All SZGR 2.0 genes in this pathway
Reactome脂质消化和运输 46 37 All SZGR 2.0 genes in this pathway
反应组有丝分裂起点 87 51 All SZGR 2.0 genes in this pathway
TGFβ受体复合物的反应组信号传导 63 42 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
Choi ATL慢性与急性DN 18 10 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应 770 415 All SZGR 2.0 genes in this pathway
Appierto对Fenretinide DN的反应 51 35 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT网络 168 103 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络 423 265 All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
Pujana BRCA中心网络 117 72 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
洛佩兹MBD目标 957 597 All SZGR 2.0 genes in this pathway
COLLIS PRKDC REGULATORS 15 10 All SZGR 2.0 genes in this pathway
Kim生发中心T助手 66 42 All SZGR 2.0 genes in this pathway
Peart HDAC增殖集群 57 35 All SZGR 2.0 genes in this pathway
Sasaki成人T细胞白血病 176 122 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS 41 26 All SZGR 2.0 genes in this pathway
kaab失败的心房DN 141 99 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
Sesto对UV C0的反应 107 72 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
马丁内斯对trabectedin dn的反应 271 175 All SZGR 2.0 genes in this pathway
Matzuk精子分化 37 26 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤 207 143 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
研究糖原代谢 21 16 All SZGR 2.0 genes in this pathway
中村脂肪形成晚期 104 67 All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 UP 22 14 All SZGR 2.0 genes in this pathway
lu eszh2靶向DN 414 237 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
CTBP1的Purbey目标不是SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-128 433 440 1A，M8 hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
miR-135 623 629 M8 HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
miR-140 429 435 M8 HSA-MIR-140brain AGUGGUUUUACCCUAUGGUAG
miR-184 889 895 1a HSA-MIR-184 uggacggaaCugauaagggu
miR-186 967 974 1A，M8 HSA-MIR-186 caaagaauuuugggcuu
HSA-MIR-186 caaagaauuuugggcuu
mir-218 586 592 M8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-27 434 441 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
miR-34/449 13 19 M8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c Aggcaguguaguagcugauugc
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B AGGCAGUGUAUUGUUAGCUGGC
miR-34b 14 21 1A，M8 hsa-miR-34b uaggcagugucauagcugauug
mir-411 1110 1117 1A，M8 hsa-miR-411 aacacgguccacuaacccucagu
miR-493-5p 501 508 1A，M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
HSA-MIR-493-5p uuguacaugguaggcuuucauu
HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-496 335 342 1A，M8 HSA-MIR-496 Auuacauggccaaucuc