Gene Page:THAP1

Summary?
GeneID 55145
Symbol THAP1
Synonyms DYT6
Description THAP domain containing, apoptosis associated protein 1
Reference MIM:609520|HGNC:HGNC:20856|Ensembl:ENSG00000131931|HPRD:15496|Vega:OTTHUMG00000165276
Gene type protein-coding
Map location 8p11.21
Pascal p-value 0.029
Fetal beta 1.153
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03301282 8 42698936 THAP1 2.11E-5 -0.588 0.017 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AP2B1 ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743 adaptor-related protein complex 2, beta 1 subunit Two-hybrid BioGRID 16189514
C1orf35 MGC4174 | MMTAG2 chromosome 1 open reading frame 35 Two-hybrid BioGRID 16189514
DVL2 - dishevelled, dsh homolog 2 (Drosophila) Two-hybrid BioGRID 16189514
FXR2 FMR1L2 fragile X mental retardation, autosomal homolog 2 Two-hybrid BioGRID 16189514
GRINL1A DKFZp586F1918 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A Two-hybrid BioGRID 16189514
NKAP FLJ22626 NFKB activating protein Two-hybrid BioGRID 16189514
NUP62 DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62 nucleoporin 62kDa Two-hybrid BioGRID 16189514
PAWR PAR4 | Par-4 PRKC, apoptosis, WT1, regulator - HPRD,BioGRID 12717420
PHF1 MTF2L2 | PCL1 | PHF2 PHD finger protein 1 Two-hybrid BioGRID 16189514
RALYL HNRPCL3 RALY RNA binding protein-like Two-hybrid BioGRID 16189514
STRBP DKFZp434N214 | FLJ11307 | FLJ14223 | FLJ14984 | ILF3L | MGC21529 | MGC3405 | SPNR | p74 spermatid perinuclear RNA binding protein Two-hybrid BioGRID 16189514
THAP1 FLJ10477 | MGC33014 THAP domain containing, apoptosis associated protein 1 Two-hybrid BioGRID 16189514
U2AF2 U2AF65 U2 small nuclear RNA auxiliary factor 2 Two-hybrid BioGRID 16189514
ZCCHC10 FLJ20094 zinc finger, CCHC domain containing 10 Two-hybrid BioGRID 16189514
ZNF408 FLJ12827 zinc finger protein 408 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 57 32 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway