基因页：PPP2R1A

Summary?
基因 5518
象征 PPP2R1A
Synonyms MRD36|PP2A-Aalpha|PP2AAALPHA|PR65A
Description protein phosphatase 2 regulatory subunit A, alpha
Reference MIM:605983|HGNC：HGNC：9302|HPRD:16184|
基因type protein-coding
地图位置 19q13.41
Pascal P值 0.406
Sherlock p-value 0.45
Fetal beta -0.659
支持 细胞内信号转导
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2CDB.HUMANNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet
Darnell FMRP目标
Potential synaptic genes

基因in Data Sources
基因set name 基因组方法 Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
简历：PGCNP 全基因组协会研究 GWAS
网络 Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.4639

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
共有269个时间点秘密策划,n = 38胎儿samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
EIF4ENIF1 0.92 0.92
C6orf168 0.92 0.92
TRPC4AP 0.91 0.91
RTN1 0.91 0.90
CS 0.91 0.91
KIFAP3 0.91 0.92
VPS26B 0.90 0.91
eftud2 0.90 0.92
RUSC1 0.90 0.92
AP1M1 0.90 0.90
前10个负共表达基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
AF347015.31 -0.84 -0.86
MT-CO2 -0.83 -0.86
AF347015.8 -0.82 -0.87
AF347015.33 -0.82 -0.84
AF347015.27 -0.81 -0.85
MT-CYB -0.81 -0.84
AF347015.15 -0.79 -0.84
AF347015.2 -0.79 -0.85
AF347015.26 -0.78 -0.85
FXYD1 -0.78 -0.83

Section III. Gene Ontology annotation

分子功能 去term Evidence Neuro keywords PubMed ID
GO:0003823 抗原结合 新闻学会 9847399
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 9847399
GO:0008601 蛋白质磷酸酶2A调节剂活性 TAS 11007961
GO：0046982 蛋白质异二聚化活性 新闻学会 9847399
生物过程 去term Evidence Neuro keywords PubMed ID
GO:0000188 inactivation of MAPK activity NAS 11007961
去：0008380 RNA splicing NAS 11007961
去：0006461 protein complex assembly TAS 9989501
去：0006470 蛋白氨基酸去磷酸化 TAS 11007961
GO:0010033 response to organic substance NAS 11007961
去：0006275 regulation of DNA replication NAS 11007961
GO:0006917 induction of apoptosis TAS 11007961
GO:0006672 神经酰胺代谢过程 NAS 11007961
去：0030111 regulation of Wnt receptor signaling pathway NAS 11007961
去：0030155 regulation of cell adhesion NAS 11007961
GO：0042518 STAT3蛋白的酪氨酸磷酸化的负调节 NAS 11007961
GO:0040008 regulation of growth NAS 11360189
GO:0019932 第二混合物介导的信号传导 NAS 11007961
GO:0030308 细胞生长的负调控 NAS 11007961
GO:0045595 细胞分化调节 NAS 11360189
GO:0045449 regulation of transcription NAS 11007961
Cellular component 去term Evidence Neuro keywords PubMed ID
GO:0000159 蛋白质磷酸酶2a型复合物 TAS 11007961
GO:0005829 cytosol IEA -
GO:0005829 cytosol TAS 11007961
GO:0005625 可溶性部分 NAS 11007961
GO:0005634 nucleus NAS 11007961
GO:0005739 线粒体 NAS 11007961
去：0016020 membrane NAS 11007961
GO:0015630 微管细胞骨架 NAS 11007961

Section IV. Protein-protein interaction annotation

互动者 Aliases B Official full name B Experimental Source PubMed ID
Arih2 ARI2 | FLJ10938 | FLJ33921 | TRIAD1 ariadne homolog 2 (Drosophila) Two-hybrid BioGRID 16169070
CTNNBIP1 ICAT |MGC15093 Catenin，β相互作用蛋白1 Affinity Capture-MS BioGRID 17353931
CTTNBP2 C7orf8 |cortbp2 |FLJ34229 |KIAA1758 |MGC104579 |ORF4 cortactin binding protein 2 Affinity Capture-MS BioGRID 18782753
CTTNBP2NL DKFZp547A023 | FLJ13278 cttnbp2 n末端 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 18782753
FAM40A FLJ14743 |KIAA1761 |MGC148091 |RP4-773N10.1 具有序列相似性40的家庭，成员a Affinity Capture-MS
Affinity Capture-Western		 BioGRID 18782753
GNA12 MGC104623 |MGC99644 |nnx3 |rmp |GEP 鸟嘌呤核苷酸结合蛋白（G蛋白）α12 Galpha12 interacts with Aalpha. This interaction was modelled on a demonstrated interaction between mouse Galpha12 and human Aalpha. BIND 15525651
grin1 NMDA1 |NMDAR1 |NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 10862698
GRIN2D EB11 |NMDAR2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D - HPRD 10862698
HSF2 MGC117376 | MGC156196 | MGC75048 heat shock transcription factor 2 - HPRD 10224043
IKBKE ikk-i |ikke |ikki |KIAA0151 |MGC125294 |MGC125295 |MGC125297 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Affinity Capture-MS BioGRID 17353931
IPO9 DKFZp761M1547 | FLJ10402 | Imp9 importin 9 - HPRD 12670497
MAP3K3 MAPKKK3 | MEKK3 mitogen-activated protein kinase kinase kinase 3 - HPRD 14743216
MCC DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 mutated in colorectal cancers Affinity Capture-MS BioGRID 17353931
MOBKL3 2C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3 MOB1，MPS一个粘合激酶激活剂样3（酵母） Affinity Capture-MS BioGRID 18782753
NFKB2 LYT-10 | LYT10 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) - HPRD 14743216
PDCD10 CCM3 | MGC1212 | MGC24477 | TFAR15 程序性细胞死亡10 Affinity Capture-MS BioGRID 18782753
PPFIA1 FLJ41337 |FLJ42630 |FLJ43474 |嘴唇1 |lip1 |Liprin |MGC26800 蛋白质酪氨酸磷酸酶，受体类型，F多肽（PTPRF），相互作用蛋白（Liprin），α1 Affinity Capture-MS BioGRID 18782753
PPFIA2 FLJ41378 | MGC132572 蛋白酪氨酸磷酸酶，受体类型，F多肽（PTPRF），相互作用蛋白（Liprin），α2 Affinity Capture-MS BioGRID 18782753
ppme1 FLJ22226 |PME-1 蛋白质磷酸酶甲基酯酶1 Affinity Capture-MS BioGRID 18782753
PPP2CA pp2ac |pp2ca |RP-C 蛋白质磷酸酶2（以前为2A），催化亚基，α同工型 Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
PPP2CA pp2ac |pp2ca |RP-C 蛋白质磷酸酶2（以前为2A），催化亚基，α同工型 A-alpha subunit interacts with C-alpha subunit of PP2A. BIND 12370081
PPP2CB pp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
ppp2r1b MGC26454 | PR65B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform Affinity Capture-MS BioGRID 18782753
PPP2R2A B55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55A protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
PPP2R2C B55-GAMMA | IMYPNO | IMYPNO1 | MGC33570 | PR52 | PR55G 蛋白质磷酸酶2（以前为2A），调节亚基B，γ同工型 Affinity Capture-MS BioGRID 18782753
PPP2R2D MDS026 蛋白质磷酸酶2，调节亚基B，三角洲同工型 Affinity Capture-MS BioGRID 18782753
PPP2R3B NY-REN-8 |PPP2R3L |ppp2r3ly |PR48 protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
PPP2R5A B56A | MGC131915 | PR61A protein phosphatase 2, regulatory subunit B', alpha isoform Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
PPP2R5C B56G |MGC23064 |Pr61g protein phosphatase 2, regulatory subunit B', gamma isoform Affinity Capture-MS BioGRID 18782753
PPP2R5D B56D | MGC2134 | MGC8949 蛋白质磷酸酶2，调节亚基B'，三角洲同工型 Affinity Capture-MS BioGRID 18782753
PPP2R5E - 蛋白质磷酸酶2，调节亚基B'，Epsilon同工型 Affinity Capture-MS BioGRID 18782753
PPP4C pp4 |pph3 |ppx 蛋白质磷酸酶4（以前为X），催化亚基 Affinity Capture-MS BioGRID 17353931|18715871
PPP5C FLJ36922 | PP5 | PPP5 蛋白质磷酸酶5，催化亚基 - HPRD 11504734
RP5-1000E10.4 DKFZP686A0768 |FLJ21168 |西克 suppressor of IKK epsilon Affinity Capture-MS BioGRID 18782753
RP6-213H19.1 面具|MST4 serine/threonine protein kinase MST4 Affinity Capture-MS BioGRID 18782753
STK24 MST-3 | MST3 | MST3B | STE20 | STK3 serine/threonine kinase 24 (STE20 homolog, yeast) Affinity Capture-MS BioGRID 17353931|18782753
STK25 DKFZP686J1430 |sok1 |YSK1 serine/threonine kinase 25 (STE20 homolog, yeast) Affinity Capture-MS BioGRID 18782753
STRN MGC125642 | SG2NA 纹状体，钙调蛋白结合蛋白 Affinity Capture-MS BioGRID 18782753
STRN3 SG2NA 纹状体，钙调蛋白结合蛋白3 Affinity Capture-MS BioGRID 18782753
STRN4 FLJ35594 | ZIN | zinedin 纹状体，钙调蛋白结合蛋白4 Affinity Capture-MS BioGRID 18782753
traf3ip3 DJ434O14.3 | FLJ44151 | MGC117354 | MGC163289 | T3JAM TRAF3 interacting protein 3 Affinity Capture-MS BioGRID 18782753


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
kegg wnt信号通路 151 112 All SZGR 2.0 genes in this pathway
kegg tgf beta信号通路 86 64 All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
KEGG长期抑郁症 70 53 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
WNT SIGNALING 89 71 All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 46 25 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB途径 129 103 All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 34 26 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 65 41 All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导 217 167 All SZGR 2.0 genes in this pathway
Reactome CTNNB1磷酸化级联反应 16 11 All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING 14 9 All SZGR 2.0 genes in this pathway
Reactome Trif介导的TLR3信号传导 74 54 All SZGR 2.0 genes in this pathway
FGFR信号的Reactome负调节 37 24 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 24 20 All SZGR 2.0 genes in this pathway
Reactome Erk被灭活 12 9 All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS 21 17 All SZGR 2.0 genes in this pathway
反应组糖酵解 29 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME能量代谢的集成 120 84 All SZGR 2.0 genes in this pathway
Reactome细胞周期有丝分裂 325 185 All SZGR 2.0 genes in this pathway
Reactome阿片类药物信号传导 78 56 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 25 20 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 38 23 All SZGR 2.0 genes in this pathway
Reactome G1 S过渡 112 63 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
Reactome CTLA4抑制信号传导 21 15 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
READEM RNA的代谢 330 155 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 50 37 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
Reactome有丝分裂G2 G2 M相 81 50 All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 78 49 All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL 16 9 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
Reactome NFKB和MAP激酶激活由TLR4信号传导介导 72 53 All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 6 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 35 17 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
反应组止血 466 331 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 87 51 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
Reactome免疫系统 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 69 42 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR DN 23 16 All SZGR 2.0 genes in this pathway
MYC增强的Schlosser血清反应 108 74 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
洛佩兹MBD目标 957 597 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 40 31 All SZGR 2.0 genes in this pathway
KIM胃癌化学敏感性 103 64 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
dazard UV响应集群G4 21 15 All SZGR 2.0 genes in this pathway
周TNF信号30分钟 54 36 All SZGR 2.0 genes in this pathway
Zamora NOS2靶向DN 96 71 All SZGR 2.0 genes in this pathway
URS脂肪细胞分化DN 30 20 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
张乳腺癌祖细胞 425 253 All SZGR 2.0 genes in this pathway
等级转移DN 45 31 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S2 115 74 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 91 59 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
CTBP1的Purbey目标不是SATB1 DN 448 282 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-15/16/195/424/497 290 296 m8 hsa-miR-15abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain uagcagcacaucaugguuaca
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 Cagcagcaauucauguuuugaa
hsa-miR-497 cagcagcacacuguguuugu
miR-338 1 7 1a hsa-miR-338brain uccagauuuuuguuga