Gene Page:NADSYN1
Summary?
| GeneID | 55191 |
| Symbol | NADSYN1 |
| Synonyms | - |
| Description | NAD synthetase 1 |
| Reference | MIM:608285|HGNC:HGNC:29832|Ensembl:ENSG00000172890|HPRD:16309|Vega:OTTHUMG00000167375 |
| Gene type | protein-coding |
| Map location | 11q13.4 |
| Pascal p-value | 0.43 |
| Sherlock p-value | 0.395 |
| Fetal beta | 0.047 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cortex Putamen basal ganglia |
基因数据urces
| 基因集名称 | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07864189 | 11 | 71164265 | NADSYN1 | 1.32E-8 | -0.007 | 5.27E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs368755383 | 11 | 71146248 | NADSYN1 | ENSG00000172890.7 | 4.277E-7 | 0.01 | -17907 | gtex_brain_putamen_basal |
| rs12793530 | 11 | 71161656 | NADSYN1 | ENSG00000172890.7 | 2.905E-6 | 0.01 | -2499年 | gtex_brain_putamen_basal |
| rs11546509 | 11 | 71162785 | NADSYN1 | ENSG00000172890.7 | 2.921E-6 | 0.01 | -1370 | gtex_brain_putamen_basal |
| rs2002064 | 11 | 71163420 | NADSYN1 | ENSG00000172890.7 | 2.082E-6 | 0.01 | -735 | gtex_brain_putamen_basal |
| rs2002063 | 11 | 71163476 | NADSYN1 | ENSG00000172890.7 | 2.973E-6 | 0.01 | -679 | gtex_brain_putamen_basal |
| rs11600860 | 11 | 71164019 | NADSYN1 | ENSG00000172890.7 | 3.124E-6 | 0.01 | -136 | gtex_brain_putamen_basal |
| rs11606611 | 11 | 71164046 | NADSYN1 | ENSG00000172890.7 | 3.616E-6 | 0.01 | -109 | gtex_brain_putamen_basal |
| rs11606612 | 11 | 71164047 | NADSYN1 | ENSG00000172890.7 | 3.139E-6 | 0.01 | -108 | gtex_brain_putamen_basal |
| rs11606631 | 11 | 71164121 | NADSYN1 | ENSG00000172890.7 | 3.046E-6 | 0.01 | -34 | gtex_brain_putamen_basal |
| rs12789751 | 11 | 71164471 | NADSYN1 | ENSG00000172890.7 | 3.097E-6 | 0.01 | 316 | gtex_brain_putamen_basal |
| rs12791871 | 11 | 71164544 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 389 | gtex_brain_putamen_basal |
| rs1792315 | 11 | 71165547 | NADSYN1 | ENSG00000172890.7 | 2.679E-6 | 0.01 | 1392 | gtex_brain_putamen_basal |
| rs7944926 | 11 | 71165625 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 1470 | gtex_brain_putamen_basal |
| rs12785878 | 11 | 71167449 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 3294 | gtex_brain_putamen_basal |
| rs4944958 | 11 | 71168073 | NADSYN1 | ENSG00000172890.7 | 3.107E-6 | 0.01 | 3918 | gtex_brain_putamen_basal |
| rs4944959 | 11 | 71168234 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 4079 | gtex_brain_putamen_basal |
| rs12793224 | 11 | 71168710 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 4555 | gtex_brain_putamen_basal |
| rs12794668 | 11 | 71168715 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 4560 | gtex_brain_putamen_basal |
| rs2276360 | 11 | 71169547 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 5392 | gtex_brain_putamen_basal |
| rs12790010 | 11 | 71170653 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 6498 | gtex_brain_putamen_basal |
| rs12806844 | 11 | 71170770 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 6615 | gtex_brain_putamen_basal |
| rs12808368 | 11 | 71170817 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 6662 | gtex_brain_putamen_basal |
| rs12790558 | 11 | 71170905 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 6750 | gtex_brain_putamen_basal |
| rs11233747 | 11 | 71171642 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 7487 | gtex_brain_putamen_basal |
| rs34448346 | 11 | 71171743 | NADSYN1 | ENSG00000172890.7 | 3.698E-6 | 0.01 | 7588 | gtex_brain_putamen_basal |
| rs11600569 | 11 | 71173747 | NADSYN1 | ENSG00000172890.7 | 3.06E-6 | 0.01 | 9592 | gtex_brain_putamen_basal |
| rs1629220 | 11 | 71174553 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 10398 | gtex_brain_putamen_basal |
| rs142902943 | 11 | 71175830 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 11675 | gtex_brain_putamen_basal |
| rs1792224 | 11 | 71176141 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 11986 | gtex_brain_putamen_basal |
| rs1792226 | 11 | 71176574 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 12419 | gtex_brain_putamen_basal |
| rs1790344 | 11 | 71176897 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 12742 | gtex_brain_putamen_basal |
| rs1790343 | 11 | 71177207 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 13052 | gtex_brain_putamen_basal |
| rs1792227 | 11 | 71177412 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 13257 | gtex_brain_putamen_basal |
| rs1790341 | 11 | 71177578 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 13423 | gtex_brain_putamen_basal |
| rs1540127 | 11 | 71179038 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 14883 | gtex_brain_putamen_basal |
| rs1792229 | 11 | 71179395 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 15240 | gtex_brain_putamen_basal |
| rs2511010 | 11 | 71180783 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 16628 | gtex_brain_putamen_basal |
| rs12224205 | 11 | 71180992 | NADSYN1 | ENSG00000172890.7 | 2.903E-6 | 0.01 | 16837 | gtex_brain_putamen_basal |
| rs1792235 | 11 | 71181473 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 17318 | gtex_brain_putamen_basal |
| rs1619577 | 11 | 71181485 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 17330 | gtex_brain_putamen_basal |
| rs1792234 | 11 | 71182018 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 17863 | gtex_brain_putamen_basal |
| rs1792233 | 11 | 71182179 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 18024 | gtex_brain_putamen_basal |
| rs1790340 | 11 | 71182589 | NADSYN1 | ENSG00000172890.7 | 1.813E-6 | 0.01 | 18434 | gtex_brain_putamen_basal |
| rs1792231 | 11 | 71182681 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 18526 | gtex_brain_putamen_basal |
| rs1790339 | 11 | 71182761 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 18606 | gtex_brain_putamen_basal |
| rs4435028 | 11 | 71183690 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 19535 | gtex_brain_putamen_basal |
| rs4616066 | 11 | 71183846 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 19691 | gtex_brain_putamen_basal |
| rs4402322 | 11 | 71184015 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 19860 | gtex_brain_putamen_basal |
| rs7935125 | 11 | 71184190 | NADSYN1 | ENSG00000172890.7 | 3.109E-6 | 0.01 | 20035 | gtex_brain_putamen_basal |
| rs2276358 | 11 | 71184498 | NADSYN1 | ENSG00000172890.7 | 1.63E-6 | 0.01 | 20343 | gtex_brain_putamen_basal |
| rs1123007 | 11 | 71185357 | NADSYN1 | ENSG00000172890.7 | 1.834E-6 | 0.01 | 21202 | gtex_brain_putamen_basal |
| rs732934 | 11 | 71186476 | NADSYN1 | ENSG00000172890.7 | 3.025E-6 | 0.01 | 22321 | gtex_brain_putamen_basal |
| rs3794057 | 11 | 71186744 | NADSYN1 | ENSG00000172890.7 | 1.819E-6 | 0.01 | 22589 | gtex_brain_putamen_basal |
| rs2017686 | 11 | 71187061 | NADSYN1 | ENSG00000172890.7 | 1.816E-6 | 0.01 | 22906 | gtex_brain_putamen_basal |
| rs3794060 | 11 | 71187679 | NADSYN1 | ENSG00000172890.7 | 2.942E-6 | 0.01 | 23524 | gtex_brain_putamen_basal |
| rs12807827 | 11 | 71203790 | NADSYN1 | ENSG00000172890.7 | 2.529E-6 | 0.01 | 39635 | gtex_brain_putamen_basal |
| rs4945008 | 11 | 71221248 | NADSYN1 | ENSG00000172890.7 | 2.658E-6 | 0.01 | 57093 | gtex_brain_putamen_basal |
| rs11604642 | 11 | 71222355 | NADSYN1 | ENSG00000172890.7 | 2.581E-6 | 0.01 | 58200 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003952 | NAD+ synthase (glutamine-hydrolyzing) activity | EXP | glutamate (GO term level: 6) | 12547821 |
| GO:0003952 | NAD+ synthase (glutamine-hydrolyzing) activity | IEA | glutamate (GO term level: 6) | - |
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 15231747 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | IEA | - | |
| GO:0016874 | ligase activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0009435 | NAD biosynthetic process | IEA | - | |
| GO:0006807 | nitrogen compound metabolic process | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 12547821 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NICOTINATE AND NICOTINAMIDE METABOLISM | 24 | 16 | 所有SZGR 2.0基因通路 |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 51 | 36 | 所有SZGR 2.0基因通路 |
| PARENT MTOR SIGNALING UP | 567 | 375 | 所有SZGR 2.0基因通路 |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | 所有SZGR 2.0基因通路 |
| BASAKI YBX1 TARGETS DN | 384 | 230 | 所有SZGR 2.0基因通路 |
| WANG CLIM2 TARGETS UP | 269 | 146 | 所有SZGR 2.0基因通路 |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | 所有SZGR 2.0基因通路 |
| KOYAMA SEMA3B TARGETS UP | 292 | 168 | 所有SZGR 2.0基因通路 |
| BENPORATH NANOG TARGETS | 988 | 594 | 所有SZGR 2.0基因通路 |
| NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON | 158 | 93 | 所有SZGR 2.0基因通路 |
| MENSE HYPOXIA UP | 98 | 71 | 所有SZGR 2.0基因通路 |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | 172 | 107 | 所有SZGR 2.0基因通路 |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | 所有SZGR 2.0基因通路 |
| MEDINA SMARCA4 TARGETS | 44 | 29 | 所有SZGR 2.0基因通路 |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | 所有SZGR 2.0基因通路 |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | 所有SZGR 2.0基因通路 |
| SMID BREAST CANCER BASAL DN | 701 | 446 | 所有SZGR 2.0基因通路 |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | 所有SZGR 2.0基因通路 |