Gene Page:PPP2R2A

Summary?
GeneID 5520
Symbol PPP2R2A
Synonyms B55A|B55ALPHA|PR52A|PR55A
Description protein phosphatase 2 regulatory subunit B, alpha
Reference MIM:604941|HGNC:HGNC:9304|Ensembl:ENSG00000221914|HPRD:09223|Vega:OTTHUMG00000163850
Gene type protein-coding
Map location 8p21.2
Pascal p-value 0.019
Sherlock p-value 1.526E-4
Fetal beta -0.37
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03086
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.098

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position 最近的基因 P (dis) Beta (dis) FDR (dis) Study
cg08317834 8 26148868 PPP2R2A 1.47E-5 -0.251 0.015 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C13orf15 0.80 0.81
CEBPD 0.79 0.79
SAT1 0.76 0.75
TM4SF1 0.76 0.78
MT2A 0.76 0.77
ACSL5 0.74 0.79
IFITM2 0.73 0.74
PLSCR1 0.73 0.72
GIMAP5 0.73 0.80
C10orf54 0.72 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SAFB -0.68 -0.77
AGPAT6 -0.67 -0.75
UBTF -0.67 -0.77
RNF40 -0.67 -0.75
GPATCH1 -0.67 -0.75
LSM14B -0.66 -0.74
NEURL4 -0.66 -0.74
SFRS14 -0.66 -0.73
GTF2F1 -0.66 -0.74
PDCD11 -0.66 -0.75

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 9847399
GO:0004722 protein serine/threonine phosphatase activity IDA 1849734
GO:0008601 protein phosphatase type 2A regulator activity IEA -
GO:0008601 protein phosphatase type 2A regulator activity TAS 1849734
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006470 protein amino acid dephosphorylation IDA 1849734
GO:0007165 signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000159 protein phosphatase type 2A complex IDA 1849734
GO:0000159 protein phosphatase type 2A complex IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ATR FRP1 | MEC1 | SCKL | SCKL1 ataxia telangiectasia and Rad3 related Protein-peptide BioGRID 10608806
EIF4EBP1 4E-BP1 | 4EBP1 | BP-1 | MGC4316 | PHAS-I eukaryotic translation initiation factor 4E binding protein 1 Affinity Capture-Western BioGRID 16899564
FAM107A DRR1 | FLJ30158 | FLJ45473 | TU3A family with sequence similarity 107, member A Affinity Capture-MS BioGRID 17353931
FRAP1 FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1 FK506 binding protein 12-rapamycin associated protein 1 Reconstituted Complex BioGRID 10200280
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 10862698
PPP2CA PP2Ac | PP2CA | RP-C protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform - HPRD,BioGRID 1328247
PPP2CB PP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Affinity Capture-MS BioGRID 18782753
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 12370081|18782753
PPP2R1B MGC26454 | PR65B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform - HPRD,BioGRID 1328247
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 RAF1 (c-Raf) interact with an unspecified isoform of PPP2R2A (PP2A-A). BIND 16041367
RPS6KB1 PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpha ribosomal protein S6 kinase, 70kDa, polypeptide 1 Affinity Capture-Western BioGRID 10200280|16899564
RRN3 DKFZp566E104 | MGC104238 | TIFIA RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) Reconstituted Complex BioGRID 15004009
STRN3 SG2NA striatin, calmodulin binding protein 3 - HPRD 10681496
TCEAL1 SIIR | p21 | pp21 transcription elongation factor A (SII)-like 1 Affinity Capture-MS BioGRID 17353931
TGFBR1 AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 transforming growth factor, beta receptor 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 9774674


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 55 38 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 38 23 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR 44 24 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 86 54 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 145 91 All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 50 36 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 41 28 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 77 52 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 72 45 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 118 65 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 380 386 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-136 149 155 1A hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-141/200a 104 110 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 380 386 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d 219 225 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106b深圳 UAAAGUGCUGACAGUGCAGAU
hsa-miR-20b深圳 CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-183 118 124 m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-218 558 564 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-221/222 452 458 1A hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-31 250 256 m8 hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG