Gene Page:NAT10

Summary?
GeneID 55226
Symbol NAT10
Synonyms ALP|NET43
Description N-acetyltransferase 10
Reference MIM:609221|HGNC:HGNC:29830|Ensembl:ENSG00000135372|HPRD:10964|Vega:OTTHUMG00000166249
Gene type protein-coding
Map location 11p13
Pascal p-value 0.002
Sherlock p-value 0.626
Fetal beta -0.067
DMG 2 (# studies)
eGene Putamen basal ganglia
Myers' cis & trans
元
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25864042 11 34127291 NAT10 1.37E-8 -0.013 5.39E-6 DMG:Jaffe_2016
cg09358725 11 33914088 NAT10 8.63E-6 4.726 DMG:vanEijk_2014
cg24453664 11 33758413 NAT10 0.001 2.324 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs12677942 chr8 31539941 NAT10 55226 0.18 trans
rs286906 11 34660659 NAT10 ENSG00000135372.4 1.11097E-6 0.01 533510 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GLTPD1 0.93 0.94
LRFN1 0.92 0.93
LRRC4B 0.92 0.93
EPN1 0.89 0.90
AC084125.1 0.89 0.90
HGS 0.88 0.90
FAM116B 0.88 0.90
ZBTB45 0.88 0.90
AC011471.1 0.88 0.90
AGPAT1 0.88 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.67 -0.67
AF347015.27 -0.66 -0.68
AF347015.21 -0.66 -0.74
MT-CO2 -0.66 -0.67
AF347015.8 -0.65 -0.67
AF347015.33 -0.64 -0.64
MT-CYB -0.64 -0.65
AF347015.15 -0.60 -0.62
NOSTRIN -0.60 -0.64
COPZ2 -0.60 -0.62

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 121 71 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway