Gene Page:SLC47A1

Summary?
GeneID 55244
Symbol SLC47A1
Synonyms MATE1
Description solute carrier family 47 member 1
Reference MIM:609832|HGNC:HGNC:25588|Ensembl:ENSG00000142494|HPRD:07703|Vega:OTTHUMG00000059466
Gene type protein-coding
Map location 17p11.2
Pascal p-value 0.005
Sherlock p-value 0.805
Fetal beta -0.684
DMG 1 (# studies)
eGene Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) β(dis) FDR (dis) Study
cg26959235 17 19437889 SLC47A1 3.03E-4 -0.302 0.04 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6587203 chr17 19671457 SLC47A1 55244 0.08 cis
rs205113 chr17 19673879 SLC47A1 55244 0.08 cis
rs205111 chr17 19675103 SLC47A1 55244 0.08 cis
rs205110 chr17 19675587 SLC47A1 55244 0.08 cis
rs205093 chr17 19685712 SLC47A1 55244 0.08 cis
rs157406 chr17 19710650 SLC47A1 55244 0.08 cis
rs157402 chr17 19720588 SLC47A1 55244 0.08 cis
rs157396 chr17 19726832 SLC47A1 55244 0.08 cis
rs157397 chr17 19729494 SLC47A1 55244 0.08 cis
rs172186 chr17 19780658 SLC47A1 55244 0.03 cis
rs281334 chr17 19782079 SLC47A1 55244 0.08 cis
rs4586510 chr17 19783973 SLC47A1 55244 0.08 cis
rs17131472 chr1 91962966 SLC47A1 55244 0.1 trans
rs6718379 chr2 18632808 SLC47A1 55244 0.08 trans
rs1016316 chr2 20235108 SLC47A1 55244 0.08 trans
snp_a-2190074 0 SLC47A1 55244 0.16 trans
rs17535450 chr2 39900012 SLC47A1 55244 0.03 trans
rs11706314 chr3 45309716 SLC47A1 55244 0 trans
rs11706394 chr3 45309907 SLC47A1 55244 0.01 trans
rs2922180 chr3 125280472 SLC47A1 55244 1.568E-5 trans
rs2971271 chr3 125450402 SLC47A1 55244 0 trans
rs2976809 chr3 125451738 SLC47A1 55244 4.074E-7 trans
rs9917710 chr3 176280218 SLC47A1 55244 0.07 trans
rs7668550 chr4 104384355 SLC47A1 55244 0 trans
rs3796892 chr4 111404774 SLC47A1 55244 0.11 trans
rs16894149 chr5 61013724 SLC47A1 55244 0.02 trans
rs6449550 chr5 61034312 SLC47A1 55244 0.03 trans
rs17242184 chr5 71135066 SLC47A1 55244 0.04 trans
rs6874540 chr5 149911669 SLC47A1 55244 0.05 trans
rs2273232 chr5 149912526 SLC47A1 55244 0.05 trans
rs11954814 chr5 155088338 SLC47A1 55244 0.17 trans
rs17056435 chr5 158453782 SLC47A1 55244 0.01 trans
rs9313797 chr5 158465457 SLC47A1 55244 0.03 trans
rs17056474 chr5 158468105 SLC47A1 55244 0.03 trans
rs17135521 chr6 2707631 SLC47A1 55244 0.19 trans
snp_a-1787926 0 SLC47A1 55244 0.19 trans
rs6939897 chr6 67913123 SLC47A1 55244 0.06 trans
rs6455226 chr6 67930295 SLC47A1 55244 0 trans
rs9387571 chr6 118600137 SLC47A1 55244 0.11 trans
rs283058 chr6 118625224 SLC47A1 55244 0.01 trans
rs9321275 chr6 131493217 SLC47A1 55244 0.03 trans
rs2056744 chr6 144952933 SLC47A1 55244 0.12 trans
rs17171399 chr7 38592476 SLC47A1 55244 0.08 trans
rs2430483 chr7 104548631 SLC47A1 55244 0.01 trans
rs2199402 chr8 9201002 SLC47A1 55244 0 trans
rs2169384 chr8 9216985 SLC47A1 55244 0.1 trans
rs1381350 chr8 9217194 SLC47A1 55244 0.14 trans
rs7841407 chr8 9243427 SLC47A1 55244 8.51E-6 trans
rs2739708 chr8 17992280 SLC47A1 55244 0.15 trans
rs714131 chr8 17992832 SLC47A1 55244 0.15 trans
rs2739726 chr8 17998576 SLC47A1 55244 0.08 trans
rs4733365 chr8 32480648 SLC47A1 55244 0.01 trans
rs2954041 chr8 32522625 SLC47A1 55244 0.11 trans
rs2919377 chr8 32573740 SLC47A1 55244 0.01 trans
rs2976526 chr8 32574650 SLC47A1 55244 0.11 trans
rs2975504 chr8 32578998 SLC47A1 55244 0.11 trans
rs17792062 chr8 129163736 SLC47A1 55244 0.15 trans
rs7029518 chr9 37782560 SLC47A1 55244 0.12 trans
rs427497 chr9 107982791 SLC47A1 55244 0.11 trans
rs998410 chr9 117622673 SLC47A1 55244 0.08 trans
rs9423711 chr10 2574802 SLC47A1 55244 0.01 trans
rs748375 chr10 33440178 SLC47A1 55244 0.07 trans
rs4514358 chr10 43861923 SLC47A1 55244 0.02 trans
rs7081666 chr10 47673800 SLC47A1 55244 0.08 trans
rs11820030 chr11 76133564 SLC47A1 55244 0.05 trans
rs17134872 chr11 76139845 SLC47A1 55244 0.01 trans
rs10751255 0 SLC47A1 55244 0.07 trans
rs11236774 chr11 76234952 SLC47A1 55244 0.01 trans
rs4149623 chr12 6450577 SLC47A1 55244 0.14 trans
rs11049036 chr12 27650292 SLC47A1 55244 0.08 trans
rs10747972 0 SLC47A1 55244 0.16 trans
rs10879027 chr12 70237156 SLC47A1 55244 0.15 trans
rs11112163 chr12 105072508 SLC47A1 55244 0.03 trans
rs11067174 chr12 115011927 SLC47A1 55244 0.05 trans
rs1750009 chr13 42657093 SLC47A1 55244 0 trans
rs7995192 chr13 50782598 SLC47A1 55244 0.17 trans
rs9596788 chr13 53924430 SLC47A1 55244 0.16 trans
rs9529974 chr13 72821935 SLC47A1 55244 0 trans
rs17720221 chr13 75182377 SLC47A1 55244 0.09 trans
rs17073665 chr13 81541961 SLC47A1 55244 0.01 trans
rs11840833 chr13 94378306 SLC47A1 55244 0.03 trans
rs7319060 chr13 95146303 SLC47A1 55244 0.15 trans
rs10142086 chr14 35135892 SLC47A1 55244 0.13 trans
rs2093759 chr14 97171024 SLC47A1 55244 0.01 trans
rs17244419 chr14 97171074 SLC47A1 55244 9.133E-4 trans
rs7165622 chr15 93979910 SLC47A1 55244 0.1 trans
rs13380712 chr16 25601181 SLC47A1 55244 0.02 trans
rs17294918 chr16 52717122 SLC47A1 55244 0.08 trans
rs17841422 chr17 20969134 SLC47A1 55244 0.03 trans
rs8079075 chr17 38010814 SLC47A1 55244 0.18 trans
rs16940550 chr18 13442256 SLC47A1 55244 0.19 trans
rs7236407 chr18 47827597 SLC47A1 55244 0.08 trans
rs4987765 chr18 60905021 SLC47A1 55244 0.17 trans
rs11873703 chr18 61448702 SLC47A1 55244 5.818E-6 trans
rs6095741 chr20 48666589 SLC47A1 55244 1.222E-5 trans
rs2408239 chr21 23332625 SLC47A1 55244 0.13 trans
rs17191809 chr21 36444778 SLC47A1 55244 0.04 trans
rs6000401 chr22 37149335 SLC47A1 55244 0.05 trans
rs5991662 chrX 43335796 SLC47A1 55244 0.06 trans
rs35416333 17 19427842 SLC47A1 ENSG00000142494.9 3.106E-7 0.01 29144 gtex_brain_putamen_basal
rs2440164 17 19428610 SLC47A1 ENSG00000142494.9 7.362E-7 0.01 29912 gtex_brain_putamen_basal
rs2440165 17 19428719 SLC47A1 ENSG00000142494.9 1.174E-6 0.01 30021 gtex_brain_putamen_basal
rs11870808 17 19429379 SLC47A1 ENSG00000142494.9 9.186E-7 0.01 30681 gtex_brain_putamen_basal
rs8071709 17 19429790 SLC47A1 ENSG00000142494.9 1.267E-6 0.01 31092 gtex_brain_putamen_basal
rs2453578 17 19430645 SLC47A1 ENSG00000142494.9 1.269E-6 0.01 31947 gtex_brain_putamen_basal
rs111374932 17 19431959 SLC47A1 ENSG00000142494.9 1.624E-6 0.01 33261 gtex_brain_putamen_basal
rs11871125 17 19432393 SLC47A1 ENSG00000142494.9 1.066E-6 0.01 33695 gtex_brain_putamen_basal
rs2453579 17 19435278 SLC47A1 ENSG00000142494.9 4.344E-6 0.01 36580 gtex_brain_putamen_basal
rs2252281 17 19437187 SLC47A1 ENSG00000142494.9 6.098E-7 0.01 38489 gtex_brain_putamen_basal
rs2453580 17 19438321 SLC47A1 ENSG00000142494.9 1.261E-6 0.01 39623 gtex_brain_putamen_basal
rs2453581 17 19438560 SLC47A1 ENSG00000142494.9 2.583E-7 0.01 39862 gtex_brain_putamen_basal
rs370142316 17 19438749 SLC47A1 ENSG00000142494.9 1.213E-6 0.01 40051 gtex_brain_putamen_basal
rs2453582 17 19439066 SLC47A1 ENSG00000142494.9 2.583E-7 0.01 40368 gtex_brain_putamen_basal
rs894680 17 19440538 SLC47A1 ENSG00000142494.9 1.768E-7 0.01 41840 gtex_brain_putamen_basal
rs2453583 17 19442036 SLC47A1 ENSG00000142494.9 7.088E-7 0.01 43338 gtex_brain_putamen_basal
rs2453584 17 19443445 SLC47A1 ENSG00000142494.9 2.198E-7 0.01 44747 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 89 54 All SZGR 2.0 genes in this pathway
REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 11 6 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 85 57 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17P11 AMPLICON 10 8 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
CLAUS PGR POSITIVE MENINGIOMA UP 10 7 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP 89 62 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 80 54 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
SUMI HNF4A TARGETS 34 14 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway