基因页：PPP3CA

Summary?
基因 5530
Symbol PPP3CA
同义词 CALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2B
描述 蛋白质磷酸酶3催化亚基α
参考 MIM：114105|HGNC:HGNC:9314|ENSEMBL：ENSG00000138814|HPRD：00234|Vega:OTTHUMG00000133839
基因type protein-coding
地图位置 4q24
Pascal P值 0.018
Sherlock P值 0.696
Fetal beta -1.544
支持 细胞内信号转导
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet
Darnell FMRP目标
Potential synaptic genes

基因in Data Sources
基因set name 基因组方法 描述 Info
简历：PGCNP 全基因组协会研究 GWAS
PMID:cooccur 高通量文献搜索 系统的搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 Click to show details
go_annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
网络 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 6.0623

部分即遗传学和表观遗传学注释


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
TMF1 0.94 0.95
PIK3C3 0.94 0.93
波尔克 0.93 0.95
AppBP2 0.93 0.93
Cul4b 0.92 0.94
IPO7 0.92 0.94
TTC21B 0.92 0.93
API5L1 0.92 0.92
KIAA1012 0.92 0.93
ZBTB11 0.91 0.93
前10个负共表达基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
MT-CO2 -0.69 -0.74
FXYD1 -0.68 -0.74
AF347015.31 -0.68 -0.73
higd1b -0.67 -0.74
ifi27 -0.67 -0.74
AF347015.21 -0.66 -0.71
MT-CYB -0.65 -0.70
CST3 -0.65 -0.73
CXCL14 -0.65 -0.72
AF347015.8 -0.65 -0.71

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005506 iron ion binding IEA -
GO:0005509 calcium ion binding NAS 8392375
GO:0005516 钙调蛋白结合 NAS 8392375
GO:0004722 protein serine/threonine phosphatase activity NAS 8392375
GO:0016787 hydrolase activity IEA -
去：0008270 锌离子结合 IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO：0050804 regulation of synaptic transmission IEA 神经元，突触（GO期限：7） -
GO:0000082 G1/S transition of mitotic cell cycle IEA -
GO:0006470 蛋白氨基酸去磷酸化 NAS 8392375
GO:0006950 response to stress IEA -
GO:0006606 protein import into nucleus IEA -
GO:0006816 calcium ion transport IEA -
GO:0048741 骨骼肌纤维发育 IEA -
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IEA -
去：0030018 Z光盘 IEA -
去：0005955 calcineurin complex NAS 8392375

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 苏rce PubMed ID
ADRB2 ADRB2R | ADRBR | B2AR | BAR | BETA2AR 肾上腺素，β-2-，受体，表面 Co-fractionation BioGRID 9880537
AKAP5 AKAP75 |AKAP79 |H21 激酶（PRKA）锚蛋白5 - HPRD，Biogrid 7528941|9765270
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD，Biogrid 7593193|9109491
C16orf74 MGC17624 chromosome 16 open reading frame 74 Two-hybrid BioGRID 16189514
机舱1 该隐|KIAA0330 |ppp3in calcineurin binding protein 1 Two-hybrid BioGRID 9655484
机舱1 该隐|KIAA0330 |ppp3in calcineurin binding protein 1 - HPRD 11714752
casp3 CPP32 | CPP32B | SCA-1 caspase 3，与凋亡相关的半胱氨酸肽酶 - HPRD 11478781
CRTC2 RP11-422P24.6 | TORC2 CREB调控转录共激活因子2 TORC2与CNA相互作用。 BIND 15454081
FKBP1A FKBP-12 |FKBP1 |FKBP12 |FKBP12C |PKC12 |PKCI2 |PPIASE FK506 binding protein 1A, 12kDa - HPRD 7543369
FKBP8 FKBP38 | FKBPr38 FK506结合蛋白8，38KDA - HPRD 12510191
myoz1 CS-2 | FATZ | MYOZ myozenin 1 Affinity Capture-Western BioGRID 11114196
myoz2 C4orf5 |CS-1 myozenin 2 Affinity Capture-Western BioGRID 11114196
myoz2 C4orf5 |CS-1 myozenin 2 - HPRD 11842093
myoz3 CS-3 |CS3 |frp3 myozenin 3 - HPRD 11842093
PPIA cypa |Cyph |MGC117158 |MGC12404 |MGC23397 peptidylprolyl isomerase A (cyclophilin A) - HPRD，Biogrid 12218175
PRKCZ PKC-Zeta |PKC2 protein kinase C, zeta - HPRD 12021260
RCAN1 ADAPT78 | CSP1 | DSC1 | DSCR1 | MCIP1 | RCN1 钙调蛋白1的调节剂1 - HPRD，Biogrid 10861295
RCAN2 CSP2 |DSCR1L1 |MCIP2 |rcn2 |Zaki-4 |Zaki4 |HRCN2 钙调神经素2的调节剂 Reconstituted Complex BioGRID 12102656
SOD1 ALS |ALS1 |IPOA |草皮|同二聚体 超氧化物歧化酶1，可溶性 - HPRD 11513882


V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
kegg凋亡 88 62 All SZGR 2.0 genes in this pathway
kegg wnt信号通路 151 112 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
kegg vegf信号通路 76 53 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
kegg t细胞受体信号通路 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
kegg长期增强 70 57 All SZGR 2.0 genes in this pathway
Kegg阿尔茨海默氏病 169 110 All SZGR 2.0 genes in this pathway
KEGG肌萎缩性侧索硬化症ALS 53 43 All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 37 28 All SZGR 2.0 genes in this pathway
Biocarta HDAC途径 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY 21 17 All SZGR 2.0 genes in this pathway
Biocarta ndkdynamin途径 21 15 All SZGR 2.0 genes in this pathway
Biocarta FCER1途径 41 30 All SZGR 2.0 genes in this pathway
Biocarta FMLP途径 39 29 All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY 29 26 All SZGR 2.0 genes in this pathway
Biocarta NFAT途径 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY 24 21 All SZGR 2.0 genes in this pathway
Biocarta CK1途径 17 17 All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY 26 20 All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY 23 16 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
Biocarta TCR途径 49 37 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
PID BCR 5 Pathway 65 50 All SZGR 2.0 genes in this pathway
PID IL12 2 Pathway 63 54 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 84 61 All SZGR 2.0 genes in this pathway
PID TCR钙途径 29 23 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 33 29 All SZGR 2.0 genes in this pathway
GPCR的反应组信号传导 920 449 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 25 20 All SZGR 2.0 genes in this pathway
家长mtor信号向上 567 375 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER UP 96 57 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS 579 346 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向DN 240 171 All SZGR 2.0 genes in this pathway
Senese HDAC3靶向 501 327 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781年 1082 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 150 93 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
pDGFB DN的Johansson神经胶质作用 21 16 All SZGR 2.0 genes in this pathway
Lang MyB家庭目标 29 16 All SZGR 2.0 genes in this pathway
Schlosser血清反应DN 712 443 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
Benporath Myc Max目标 775 494 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 74 48 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 52 34 All SZGR 2.0 genes in this pathway
der ifn beta响应 102 67 All SZGR 2.0 genes in this pathway
萨那对ifng的回应 78 50 All SZGR 2.0 genes in this pathway
der ifn伽马响应 71 45 All SZGR 2.0 genes in this pathway
XU对维甲酸DN的响应 13 8 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8 72 56 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 60 42 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
由Foxp3绑定的Marson未刺激 1229 713 All SZGR 2.0 genes in this pathway
伽马和紫外线辐射受kyng DNA损伤 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER UP 20 14 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 1 DN 63 39 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3 DN 918 550 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
CTBP1的Purbey目标不是SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 98 67 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS DN 19 10 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
Let-7/98 638 644 1a HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 ugagguaguagguuguaugguu
HSA-LET-7D脑 AGAGGUAGUAGGUUGCAUAGU
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 ugagguagauuguauauaguu
HSA-MIR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ ugagguaguuguuguacagu
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
mir-103/107 68 74 1a hsa-miR-103脑 AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107脑 agcagcauuguacgggcuauca
mir-142-3p 1411 1417 1a HSA-MIR-142-3P uguaguuuccuacuuuaugga
mir-142-5p 1029 1036 1a,m8 HSA-MIR-142-5P CAUAAAGUAGAAAGCACUAC
mir-145 736 743 1a,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
mir-153 925 931 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
mir-17-5p/20/93.mr/106/519.D 2048 2054 m8 HSA-MIR-17-5P CAAAGUGCUUACAGUGCAGGUAGU
HSA-MIR-20A脑 uaaagugcuuauagugcagguag
HSA-MIR-106A aaaagugcuuacugugcagguagc
HSA-MIR-106BSZ uaaagugcugacagugcagau
HSA-MIR-20BSZ caaagugcuugugcagguag
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
mir-186 648 654 1a hsa-miR-186 caaagaauuuugggcuu
miR-208 541 547 1a HSA-MIR-208 AUAAGACGAGCAAAAAGCUUGU
mir-21 1129 1135 m8 HSA-MIR-21脑 uagcuuaucagacugauguuga
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-30-3p 1346 1352 1a hsa-miR-30a-3p cuuucagucggauguugcagc
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-30-5p 412 418 1a hsa-miR-30a-5p uguaaaacauccuccugagaag
HSA-MIR-30C脑 UGUAAACAUCCUACACUCUCAGC
HSA-MIR-30DSZ UGUAAACAUCCCCGACUGGAAG
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
hsa-miR-30a-5p uguaaaacauccuccugagaag
HSA-MIR-30C脑 UGUAAACAUCCUACACUCUCAGC
HSA-MIR-30DSZ UGUAAACAUCCCCGACUGGAAG
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
mir-31 92 98 m8 HSA-MIR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-330 1083 1089 1a HSA-MIR-330脑 GCAAAGCACGGCCUGCAGAGA
mir-34b 921 927 1a HSA-MIR-34B uaggcagugucauagcugauug
mir-378* 1365 1371 m8 HSA-MIR-422B cuggacuuggagagaaggcc
HSA-MIR-422A cuggacuagggucagaaggcc
mir-381 1312 1318 1a hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-495 2019 2025 m8 hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
miR-499 540 547 1a,m8 hsa-miR-499 uuaagacuugcagugauguuaa
miR-543 292 298 1a HSA-MIR-543 AAACAUUCGCGGUGCACUUCU