Gene Page:PPP3R1

Summary?
GeneID 5534
Symbol PPP3R1
Synonyms CALNB1|CNB|CNB1
Description protein phosphatase 3 regulatory subunit B, alpha
Reference MIM:601302|HGNC:HGNC:9317|Ensembl:ENSG00000221823|HPRD:03195|Vega:OTTHUMG00000129561
Gene type protein-coding
Map location 2p15
Pascal p-value 0.013
Sherlock p-value 0.97
Fetal beta -1.33
Support INTRACELLULAR SIGNAL TRANSDUCTION
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 1.4486

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC27A4 0.91 0.90
ENO2 0.90 0.88
SV2A 0.88 0.86
KIAA0319L 0.87 0.84
MAGEE1 0.87 0.89
ABCG4 0.87 0.87
GBA2 0.86 0.83
GPI 0.86 0.83
ATP6AP1 0.86 0.85
ABCF3 0.86 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.64 -0.50
AF347015.31 -0.59 -0.46
MT-CO2 -0.57 -0.45
GNG11 -0.57 -0.50
AF347015.2 -0.56 -0.39
AF347015.8 -0.56 -0.42
AF347015.18 -0.55 -0.40
HIGD1B -0.55 -0.43
C1orf54 -0.54 -0.52
AP002478.3 -0.54 -0.48

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding NAS 2558868
GO:0005515 protein binding 新闻学会 8524402
GO:0005517 calmodulin inhibitor activity NAS 2558868
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0008633 activation of pro-apoptotic gene products EXP 15231831
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 10195903
GO:0005955 calcineurin complex NAS 2558868

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 88 62 All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 53 43 All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 63 54 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 29 23 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 33 29 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 25 20 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 17 12 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 30 21 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 32 25 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
KARAKAS TGFB1 SIGNALING 18 15 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 39 26 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 All SZGR 2.0 genes in this pathway
赛对促性腺激素DN 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 88 68 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP 49 35 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 2070 2076 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-103/107 1505 1511 1A hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a 154 160 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 2069 2076 1A,m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d 193 200 1A,m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 2010 2016 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 1642 1649 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-190 230 236 1A hsa-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-194 1826 1832 1A hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-204/211 248 255 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-221/222 189 195 1A hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-26 386 392 m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 110 116 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 1607 1614 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-342 1528 1534 1A hsa-miR-342brain UCUCACACAGAAAUCGCACCCGUC
miR-410 329 335 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-433-3p 139 145 1A hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU
miR-485-3p 2073 2080 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-485-5p 135 141 1A hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-493-5p 486 492 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-495 1824 1830 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-496 319 325 1A hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC
miR-505 2007 2013 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-543 1657 1663 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520 192 198 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU
miR-96 1643 1649 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC
hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC