Gene Page:MCM10

Summary?
GeneID 55388
Symbol MCM10
Synonyms CNA43|DNA43|PRO2249
Description minichromosome maintenance 10 replication initiation factor
Reference MIM:609357|HGNC:HGNC:18043|Ensembl:ENSG00000065328|HPRD:11297|Vega:OTTHUMG00000017694
Gene type protein-coding
Map location 10p13
Pascal p-value 0.353
Fetal beta 4.35
DMG 1 (# studies)
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp 全基因组关联研究 GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26884570 10 13204110 MCM10 3.221E-4 -0.471 0.04 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11124283 chr2 32767095 MCM10 55388 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

不可用

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CALCOCO2 MGC17318 | NDP52 calcium binding and coiled-coil domain 2 Two-hybrid BioGRID 16189514
CCDC5 FLJ21094 | FLJ40084 | HEI-C | HsT1461 coiled-coil domain containing 5 (spindle associated) - HPRD 15232106
CCDC85B DIPA coiled-coil domain containing 85B Two-hybrid BioGRID 16189514
CCND1 BCL1 | D11S287E | PRAD1 | U21B31 cyclin D1 - HPRD 15232106
CCND3 - cyclin D3 Affinity Capture-Western BioGRID 16189514
CCND3 - cyclin D3 - HPRD 15232106
CDC45L CDC45 | CDC45L2 | PORC-PI-1 CDC45 cell division cycle 45-like (S. cerevisiae) - HPRD 15232106
CDC6 CDC18L | HsCDC18 | HsCDC6 cell division cycle 6 homolog (S. cerevisiae) - HPRD 15232106
CDC7 CDC7L1 | HsCDC7 | Hsk1 | MGC117361 | MGC126237 | MGC126238 | huCDC7 cell division cycle 7 homolog (S. cerevisiae) - HPRD 15232106
CDK6 MGC59692 | PLSTIRE | STQTL11 cyclin-dependent kinase 6 - HPRD 15232106
CEP70 BITE | FLJ13036 centrosomal protein 70kDa Two-hybrid BioGRID 16189514
CEP72 FLJ10565 | KIAA1519 | MGC5307 centrosomal protein 72kDa Two-hybrid BioGRID 16189514
DPPA2 PESCRG1 developmental pluripotency associated 2 Two-hybrid BioGRID 16189514
HOOK2 FLJ26218 | HK2 hook homolog 2 (Drosophila) Two-hybrid BioGRID 16189514
KRT15 CK15 | K15 | K1CO keratin 15 Two-hybrid BioGRID 16189514
MCM2 BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19 minichromosome maintenance complex component 2 - HPRD,BioGRID 11095689|15232106
MCM2 BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19 minichromosome maintenance complex component 2 - HPRD 15232106
MCM3 HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFB minichromosome maintenance complex component 3 - HPRD,BioGRID 11095689|15232106
MCM4 CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21 minichromosome maintenance complex component 4 - HPRD,BioGRID 11095689
MCM6 MCG40308 | Mis5 | P105MCM minichromosome maintenance complex component 6 in vitro
in vivo
Two-hybrid		 BioGRID 11095689|16189514
MCM6 MCG40308 | Mis5 | P105MCM minichromosome maintenance complex component 6 - HPRD 11095689|15232106
MCM7 CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 minichromosome maintenance complex component 7 - HPRD,BioGRID 11095689|15232106
ORC2L ORC2 origin recognition complex, subunit 2-like (yeast) - HPRD,BioGRID 11095689
ORC3L LAT | LATHEO | ORC3 origin recognition complex, subunit 3-like (yeast) - HPRD 15232106
ORC4L ORC4 | ORC4P origin recognition complex, subunit 4-like (yeast) - HPRD 15232106
RP4-691N24.1 FLJ11792 | KIAA0980 | NLP | dJ691N24.1 ninein-like Two-hybrid BioGRID 16189514
TRIM37 KIAA0898 | MUL | POB1 | TEF3 tripartite motif-containing 37 Two-hybrid BioGRID 16189514
ZBTB43 ZBTB22B | ZNF-X | ZNF297B zinc finger and BTB domain containing 43 Two-hybrid BioGRID 16189514
ZBTB8 博兹F1 | FLJ90065 | MGC17919 zinc finger and BTB domain containing 8 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME激活之前复制的复杂 31 16 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 81 45 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 38 18 All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS 45 23 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 87 49 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 140 73 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH ES 2 40 21 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 480 MCF10A 39 20 All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 62 46 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN 90 55 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 66 43 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 65 44 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 65 39 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 64 38 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 74 45 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 64 42 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR UP 45 20 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184 132 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3 101 64 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 91 44 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN 41 26 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN UP 39 20 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 49 34 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 142 79 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP 107 59 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 89 50 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway