Gene Page:PLXNA3

Summary?
GeneID 55558
Symbol PLXNA3
Synonyms 6.3|HSSEXGENE|PLXN3|PLXN4|XAP-6
Description plexin A3
Reference MIM:300022|HGNC:HGNC:9101|HPRD:02062|
Gene type protein-coding
Map location Xq28
Fetal beta 1.417
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Ambalavanan_2016 Whole Exome Sequencing This dataset includes 20 de novo mutations detected in 17 COS probands.
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
PLXNA3 chrX 153692763 G A NM_017514 p.(Arg616Gln) nonsynonymous SNV 0.001 Childhood-onset schizophrenia DNM:Ambalavanan_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 -26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GLB1L2 0.59 0.38
TMPRSS13 0.57 0.38
KIAA1530 0.56 0.45
PAPPA2 0.56 0.32
WNT7B 0.55 0.32
CLCF1 0.55 0.49
CECR2 0.53 0.41
RP11-274B21.1 0.52 0.46
AC010522.1 0.52 0.45
DUOX1 0.52 0.42
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DHRS7 -0.43 -0.47
C5orf35 -0.37 -0.48
PHYH -0.36 -0.37
TMEM22 -0.36 -0.45
ACOT13 -0.36 -0.40
ITM2B -0.36 -0.40
MGST2 -0.35 -0.40
PXMP3 -0.35 -0.46
ACYP2 -0.35 -0.37
HDDC2 -0.35 -0.38

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004888 transmembrane receptor activity NAS 8570614
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007411 axon guidance IEA axon (GO term level: 13) -
GO:0021860 pyramidal neuron development IEA neuron, Brain (GO term level: 12) -
GO:0048843 negative regulation of axon extension involved in axon guidance IEA axon (GO term level: 16) -
GO:0007165 signal transduction IEA -
GO:0007275 multicellular organismal development TAS 8570614
GO:0050919 negative chemotaxis IEA -
GO:0021766 hippocampus development IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0016020 membrane TAS 8570614
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME CRMPS IN SEMA3A SIGNALING 14 14 All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 15 14 All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 13 9 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
LOPEZ MESOTELIOMA SURVIVAL TIME UP 14 8 All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL WORST VS BEST UP 14 10 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD UP 64 39 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1 67 41 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE 19 15 All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL OVERALL DN 16 8 All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL DN 12 6 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
NABA ECM附属 171 89 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 811 817 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 810 817 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-137 226 232 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG