Gene Page:ZNF821

Summary?
GeneID 55565
Symbol ZNF821
Synonyms -
Description zinc finger protein 821
Reference HGNC:HGNC:28043|Ensembl:ENSG00000102984|HPRD:14244|Vega:OTTHUMG00000176874
Gene type protein-coding
Map location 16q22.2
Pascal p-value 0.212
DEG p-value DEG:Sanders_2014:DS1_p=-0.152:DS1_beta=0.023100:DS2_p=7.11e-01:DS2_beta=-0.018:DS2_FDR=8.62e-01
Fetal beta 1.591
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06464432 16 71917996 ZNF821 8.01E-9 -0.008 3.83E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6734526 chr2 5616370 ZNF821 55565 0.18 trans
rs16829545 chr2 151977407 ZNF821 55565 3.552E-10 trans
rs3845734 chr2 171125572 ZNF821 55565 0.1 trans
rs7584986 chr2 184111432 ZNF821 55565 0.04 trans
rs17762315 chr5 76807576 ZNF821 55565 6.907E-4 trans
rs7729096 chr5 76835927 ZNF821 55565 0.04 trans
rs7787830 chr7 98797019 ZNF821 55565 0.01 trans
rs2393316 chr10 59333070 ZNF821 55565 0.14 trans
rs16955618 chr15 29937543 ZNF821 55565 1.489E-11 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC112641.2 0.83 0.88
PITPNM2 0.80 0.84
DLGAP1 0.78 0.79
AC021534.2 0.78 0.85
THRB 0.78 0.80
ARHGEF3 0.78 0.82
PKNOX2 0.77 0.80
KCNV1 0.77 0.84
CAMKK2 0.77 0.78
IQSEC2 0.77 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB13 -0.50 -0.58
DBI -0.48 -0.51
RAB34 -0.47 -0.52
MYL12A -0.46 -0.52
PECI -0.45 -0.51
NKAIN4 -0.45 -0.54
AP002478.3 -0.42 -0.45
C1orf61 -0.41 -0.48
ACAA2 -0.41 -0.40
RHOC -0.41 -0.46

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway