Gene Page:PRKAA1

Summary?
GeneID 5562
Symbol PRKAA1
Synonyms AMPK|AMPKa1
Description 蛋白质kinase AMP-activated catalytic subunit alpha 1
Reference MIM:602739|HGNC:HGNC:9376|运用:ENSG00000132356|HPRD:04115|Vega:OTTHUMG00000162269
Gene type protein-coding
Map location 5p12
Pascal p-value 0.427
Fetal beta 0.943

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.3086

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NCAM2 0.89 0.87
WASL 0.88 0.91
BAG4 0.87 0.88
SGIP1 0.86 0.88
CLOCK 0.86 0.90
WDR7 0.86 0.87
DNAJB14 0.85 0.88
USP12 0.85 0.88
PREPL 0.85 0.91
PCTK2 0.85 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AL022328.1 -0.46 -0.51
RP9P -0.44 -0.49
AC098691.2 -0.42 -0.44
RAB34 -0.41 -0.45
IRF7 -0.41 -0.48
C16orf79 -0.41 -0.41
NUDT8 -0.40 -0.42
C1orf61 -0.40 -0.47
BCL7C -0.40 -0.43
IL32 -0.39 -0.36

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005515 protein binding 新闻学会 18403135
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0004691 cAMP-dependent protein kinase activity NAS 8557660
GO:0016740 转移酶的活动 IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000187 activation of MAPK activity NAS 11546797
GO:0001666 应对hypoxia NAS 8557660
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007165 signal transduction TAS 8557660
GO:0006633 fatty acid biosynthetic process IEA -
GO:0045768 positive regulation of anti-apoptosis NAS 11165240
GO:0045542 positive regulation of cholesterol biosynthetic process NAS 8557660
GO:0046318 negative regulation of glucosylceramide biosynthetic process NAS 11165240
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IC 8557660

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG REGULATION OF AUTOPHAGY 35 30 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
BIOCARTA LEPTIN PATHWAY 11 11 All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 19 16 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 15 13 All SZGR 2.0 genes in this pathway
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 18 15 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 9 All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS 29 23 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 71 51 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 36 24 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 92 64 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK DN 20 13 All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM RISK DN 23 12 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 2777 2784 1A,m8 hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-130/301 2478 2484 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-144 2778 2784 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-148/152 2069 2076 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-153 2713 2719 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-19 123 130 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-30-3p 2744 2750 m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-33 2650 2657 1A,m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-448 2713 2719 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-496 2818 2824 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-539 2847 2854 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU