Gene Page:TTC27

Summary?
GeneID 55622
Symbol TTC27
Synonyms -
Description tetratricopeptide repeat domain 27
Reference HGNC:HGNC:25986|Ensembl:ENSG00000018699|HPRD:08618|Vega:OTTHUMG00000152134
Gene type protein-coding
Map location 2p22.3
Pascal p-value 0.649
Fetal beta 1.042
eGene Caudate basal ganglia
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs111896629 2 32903548 TTC27 ENSG00000018699.7 1.31968E-7 0.01 50449 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
YSK4 0.97 0.44
C6orf97 0.96 0.42
RSHL1 0.96 0.62
ARMC3 0.96 0.50
ARMC4 0.96 0.46
C7orf57 0.96 0.43
C6orf165 0.96 0.64
SPATA18 0.96 0.41
LRRC9 0.95 0.51
RGS22 0.95 0.37
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.19 -0.42
AF347015.2 -0.19 -0.44
AF347015.8 -0.19 -0.43
AF347015.27 -0.18 -0.40
AF347015.33 -0.18 -0.41
AF347015.15 -0.18 -0.42
GRIN2C -0.18 -0.40
MT-CYB -0.18 -0.41
AF347015.31 -0.18 -0.41
COX4I2 -0.18 -0.41

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 67 37 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION DN 45 31 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217 138 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 6 33 22 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway