Gene Page:PRKAA2

Summary?
GeneID 5563
Symbol PRKAA2
Synonyms AMPK|AMPK2|AMPKa2|PRKAA
Description 蛋白质kinase AMP-activated catalytic subunit alpha 2
Reference MIM:600497|HGNC:HGNC:9377|Ensembl:ENSG00000162409|HPRD:02735|Vega:OTTHUMG00000008282
Gene type 蛋白质-coding
Map location 1p31
Pascal p-value 0.43
Fetal beta -0.388
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25617691 1 57110686 PRKAA2 4.264E-4 -0.239 0.045 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MTCH1 0.85 0.88
RHBDD2 0.85 0.89
RUNDC3A 0.84 0.88
ALDOA 0.83 0.86
BSCL2 0.82 0.87
PDK2 0.82 0.80
RP11-401M16.2 0.81 0.87
SNRPN 0.80 0.86
PINK1 0.79 0.88
GBA 0.79 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF5B -0.50 -0.58
CCAR1 -0.46 -0.43
RBMX2 -0.45 -0.51
THOC2 -0.44 -0.44
UPF3B -0.44 -0.46
AC005921.3 -0.44 -0.65
ANKRD36B -0.41 -0.58
ZNF300 -0.41 -0.25
SCLT1 -0.41 -0.41
ATAD2B -0.41 -0.36

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG REGULATION OF AUTOPHAGY 35 30 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
BIOCARTA LEPTIN PATHWAY 11 11 All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 19 16 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME能量代谢的集成 120 84 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 15 13 All SZGR 2.0 genes in this pathway
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 18 15 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 9 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS 29 23 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 71 51 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
CORRADETTI MTOR PATHWAY REGULATORS DN 6 5 All SZGR 2.0 genes in this pathway
YANAGIHARA ESX1 TARGETS 30 19 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 39 29 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN 150 93 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 145 88 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP 84 55 All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 82 51 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway