基因Page:CCDC88A

概括?
基因ID 55704
Symbol CCDC88A
同义词 猿|吉尔丁| giv | grdn | hkrp1 | kiaa1212
描述 coiled-coil domain containing 88A
参考 MIM:609736|HGNC:HGNC:25523|Ensembl:ENSG00000115355|HPRD:10051|HPRD:11131|Vega:OTTHUMG00000151915
基因type protein-coding
地图位置 2p16.1
Pascal p-value 0.064
Fetal beta 1.006
eGene Cerebellar Hemisphere

数据源中的基因
基因set name 基因组方法 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur 高通量文献搜索 系统的海rch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details
网络 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 PPI网络中最短路径的贡献：0.1667

第一节遗传学和表观遗传学注释


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
HDAC3 0.95 0.94
BAT1 0.94 0.93
FANCG 0.93 0.90
DAXX 0.93 0.93
ZNF7 0.92 0.92
FAM48A 0.92 0.91
VPS16A 0.92 0.93
ZSCAN21 0.92 0.90
USF1 0.92 0.94
SSRP1 0.92 0.91
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
AF347015.27 -0.79 -0.90
AF347015.31 -0.78 -0.88
MT-CO2 -0.77 -0.88
AF347015.33 -0.76 -0.86
MT-CYB -0.76 -0.87
AF347015.8 -0.75 -0.88
AIFM3 -0.74 -0.77
AF347015.15 -0.74 -0.87
HLA-F -0.73 -0.74
AF347015.2 -0.72 -0.88

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
去：0003779 actin binding IDA 16139227
GO:0008017 microtubule binding ISS -
GO:0042803 protein homodimerization activity 新闻学会 16139227
GO:0035091 phosphoinositide binding IDA 16139227
GO:0043422 protein kinase B binding 新闻学会 16139227
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001932 调节蛋白氨基酸磷酸化 ISS -
GO:0016044 membrane organization IDA 15882442
GO:0006275 regulation of DNA replication ISS -
GO:0016477 cell migration 小鬼 16139227
GO:0042127 调节细胞增殖 ISS -
GO:0032956 肌动蛋白细胞骨架组织的调节 小鬼 16139227
GO：0032148 activation of protein kinase B activity ISS -
GO:0030032 lamellipodium biogenesis 小鬼 16139227
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IDA 15882442
去：0005829 cytosol IDA 15749703
GO:0005737 细胞质 IEA -
GO:0005783 endoplasmic reticulum IDA 15882442
GO:0030027 lamellipodium IDA 16139227
GO:0005886 plasma membrane IDA 15882442
GO:0031410 细胞质ic vesicle IDA 15882442

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 该途径中的所有SZGR 2.0基因
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 该途径中的所有SZGR 2.0基因
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175 120 该途径中的所有SZGR 2.0基因
Senese HDAC3靶向 501 327 该途径中的所有SZGR 2.0基因
罗德里格甲状腺癌的分化不佳 633 376 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781年 1082 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 该途径中的所有SZGR 2.0基因
patil肝癌 747 453 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS UP 769 437 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS UP 1037 673 该途径中的所有SZGR 2.0基因
Haddad T淋巴细胞和NK祖细胞 78 56 该途径中的所有SZGR 2.0基因
MCCLUNG CREB1 TARGETS DN 57 39 该途径中的所有SZGR 2.0基因
TSENG IRS1 TARGETS DN 135 88 该途径中的所有SZGR 2.0基因
RODWELL AGING KIDNEY UP 487 303 该途径中的所有SZGR 2.0基因
BURTON ADIPOGENESIS 11 57 40 该途径中的所有SZGR 2.0基因
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER NORMAL LIKE UP 476 285 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL UP 648 398 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA D CLUSTER DN 40 26 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA D DN 78 34 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 36HR DN 185 116 该途径中的所有SZGR 2.0基因
POOLA INVASIVE BREAST CANCER UP 288 168 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA PCA3 DN 69 38 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤上课 605 377 该途径中的所有SZGR 2.0基因
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN 56 39 该途径中的所有SZGR 2.0基因
WHITFIELD CELL CYCLE G2 M 216 124 该途径中的所有SZGR 2.0基因
BILANGES SERUM SENSITIVE VIA TSC2 39 25 该途径中的所有SZGR 2.0基因
CTBP1和SATB1 DN的Purbey目标 180 116 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
rao由SALL4同工型B绑定 517 302 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
miR-101 2736 2742 1A HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
mir-128 2646 2652 m8 HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
miR-129-5p 1081 1087 1A hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 2986 2992 m8 hsa-miR-130a脑 CAGUGCAAUGUUAAAAGGGCAU
HSA-MIR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130b脑 CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
mir-144 2735 2742 1A,m8 hsa-miR-144 uacaguauagauguauguaguag
miR-18 2605 2611 m8 hsa-miR-18a UAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18b uaaggugcaucuagugcagua
mir-181 479 485 1A hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
mir-182 219 225 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-19 1924 1931 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-203.1 3123 3129 m8 HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-218 1076 1083 1A,m8 HSA-MIR-218脑 uugugcuugaucuaaccaugu
mir-378 2718 2725 1A,m8 hsa-miR-378 cuccugacuccaggucugugu
miR-431 88 94 1A HSA-MIR-431 UGUCUUGCAGGCCGUCAUGCA
mir-488 2747 2753 1A hsa-miR-488 CCCAGAUAAUGGCACUCUCAA
mir-495 1051 1057 1A hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
miR-539 55 61 1A HSA-MIR-539 ggagaauuauccuuggugugu
mir-93.hd/291-3p/294/295/302/372/373/520 2988 2994 1A hsa-miR-93脑 AAAGUGCUGUUCGUGCAGGUAG
HSA-MIR-302A UAAGUGCUUCCAUGUUUUGGUGA
HSA-MIR-302B UAAGUGCUUCCAUGUUUUAGUAG
HSA-MIR-302C UAAGUGCUUCCAUGUUUCAGUGG
HSA-MIR-302D UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
HSA-MIR-520A aaagugcuucccuuguggugu
HSA-MIR-520B AAAGUGCUUCCUUUUAGAGGG
HSA-MIR-520C AAAGUGCUUCCUUUUAGAGGGUU
HSA-MIR-520D AAAGUGCUUCUCUUUGGUGGGUU
miR-96 219 225 1A hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC