Gene Page:CNDP2

Summary?
GeneID 55748
Symbol CNDP2
Synonyms CN2|CPGL|HEL-S-13|HsT2298|PEPA
Description CNDP dipeptidase 2 (metallopeptidase M20 family)
Reference MIM:169800|HGNC:HGNC:24437|Ensembl:ENSG00000133313|HPRD:09893|Vega:OTTHUMG00000132853
Gene type protein-coding
Map location 18q22.3
Pascal p-value 0.667
Sherlock p-value 0.957
DMG 2 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Nucleus accumbens basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
CNDP2 chr18 72180842 A C NM_001168499
NM_018235		 p.180E>A
p.264E>A		 missense
missense		 Schizophrenia DNM:Gulsuner_2013

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01794711 18 72163198 CNDP2 -0.023 0.26 DMG:Nishioka_2013
cg03669052 18 72164002 CNDP2 1.26E-8 -0.007 5.11E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs8083001 18 72165058 CNDP2 ENSG00000133313.10 7.43746E-7 0.03 2007 gtex_brain_ba24
rs3764509 18 72167124 CNDP2 ENSG00000133313.10 6.75222E-7 0.03 4073 gtex_brain_ba24
rs8084109 18 72168312 CNDP2 ENSG00000133313.10 6.70843E-7 0.03 5261 gtex_brain_ba24
rs8084410 18 72168486 CNDP2 ENSG00000133313.10 6.70843E-7 0.03 5435 gtex_brain_ba24
rs7229256 18 72169129 CNDP2 ENSG00000133313.10 6.70843E-7 0.03 6078 gtex_brain_ba24
rs7241558 18 72169267 CNDP2 ENSG00000133313.10 6.70843E-7 0.03 6216 gtex_brain_ba24
rs34676212 18 72170006 CNDP2 ENSG00000133313.10 6.70843E-7 0.03 6955 gtex_brain_ba24
rs4891559 18 72170397 CNDP2 ENSG00000133313.10 6.71091E-7 0.03 7346 gtex_brain_ba24
rs12971120 18 72174023 CNDP2 ENSG00000133313.10 2.66506E-6 0.03 10972 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHCHD10 0.70 0.57
KB-1839H6.1 0.70 0.56
TMEM42 0.70 0.66
FAM71E1 0.69 0.65
FAM98C 0.69 0.67
TUSC2 0.68 0.64
PGP 0.68 0.69
FDX1L 0.67 0.69
HSD11B1L 0.67 0.68
FAM108A4 0.67 0.64
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF5B -0.38 -0.47
THOC2 -0.38 -0.38
MAP4K4 -0.34 -0.33
TOP2B -0.34 -0.24
ZEB2 -0.34 -0.30
ZNF326 -0.33 -0.33
CEP170 -0.33 -0.21
RBMX2 -0.33 -0.41
AC005035.1 -0.33 -0.34
TAF1A -0.33 -0.28

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME SULFUR AMINO ACID METABOLISM 24 17 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME GLUTATHIONE CONJUGATION 23 13 All SZGR 2.0 genes in this pathway
REACTOME PHASE II CONJUGATION 70 42 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN 84 54 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 145 93 All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 134 84 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 30 22 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway