Gene Page:PRKAR1B
概括?
| 基因 | 5575 |
| Symbol | PRKAR1B |
| Synonyms | PRKAR1 |
| Description | protein kinase cAMP-dependent type I regulatory subunit beta |
| Reference | MIM:176911|HGNC:HGNC:9390|Ensembl:ENSG00000188191|HPRD:01485|Vega:OTTHUMG00000151411 |
| Gene type | protein-coding |
| Map location | 7p22 |
| Pascal p-value | 0.158 |
| Sherlock p-value | 0.904 |
| Fetal beta | -1.961 |
| DMG | 1 (# studies) |
| eGene | Cerebellum |
| Support | CANABINOID DOPAMINE INTRACELLULAR SIGNAL TRANSDUCTION SEROTONIN |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg23215256 | 7 | 631862 | PRKAR1B | 7.65E-5 | 0.251 | 0.025 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SARS | 0.84 | 0.76 |
| PPME1 | 0.82 | 0.77 |
| SLC4A1AP | 0.82 | 0.75 |
| DNAJC7 | 0.81 | 0.70 |
| DDX1 | 0.81 | 0.74 |
| DNM1L | 0.80 | 0.72 |
| IMMT | 0.80 | 0.69 |
| PSMD7 | 0.80 | 0.70 |
| PSMD1 | 0.79 | 0.73 |
| EIF2AK1 | 0.79 | 0.71 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.76 | -0.62 |
| AF347015.2 | -0.74 | -0.60 |
| AF347015.31 | -0.74 | -0.62 |
| MT-CYB | -0.73 | -0.61 |
| AF347015.21 | -0.72 | -0.56 |
| AF347015.8 | -0.72 | -0.60 |
| AF347015.26 | -0.72 | -0.60 |
| AF347015.33 | -0.72 | -0.59 |
| HIGD1B | -0.70 | -0.60 |
| AF347015.15 | -0.69 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| KEGG INSULIN SIGNALING PATHWAY | 137 | 103 | All SZGR 2.0 genes in this pathway |
| BIOCARTA第一途径 | 33 | 24 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CSK PATHWAY | 24 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA AGPCR PATHWAY | 13 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CFTR PATHWAY | 12 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA GATA3 PATHWAY | 16 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MPR PATHWAY | 34 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MCALPAIN PATHWAY | 25 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PPARA PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IGF1R PATHWAY | 23 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA VIP PATHWAY | 29 | 26 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NFAT PATHWAY | 56 | 45 | All SZGR 2.0 genes in this pathway |
| Biocarta NOS1途径 | 24 | 21 | All SZGR 2.0 genes in this pathway |
| Biocarta PLCE途径 | 12 | 10 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CHREBP2 PATHWAY | 42 | 35 | All SZGR 2.0 genes in this pathway |
| BIOCARTA坏途径 | 26 | 23 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CK1 PATHWAY | 17 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DREAM PATHWAY | 14 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA GPCR PATHWAY | 37 | 31 | All SZGR 2.0 genes in this pathway |
| BIOCARTA SHH PATHWAY | 16 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STATHMIN PATHWAY | 19 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CREB PATHWAY | 27 | 25 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CARM1 PATHWAY | 13 | 11 | All SZGR 2.0 genes in this pathway |
| PID INTEGRIN A4B1 PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME DAG AND IP3 SIGNALING | 32 | 25 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ERBB2 | 101 | 78 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY EGFR IN CANCER | 109 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR IN DISEASE | 127 | 88 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 120 | 84 | All SZGR 2.0 genes in this pathway |
| REACTOME OPIOID SIGNALLING | 78 | 56 | All SZGR 2.0 genes in this pathway |
| REACTOME CA DEPENDENT EVENTS | 30 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME DARPP 32 EVENTS | 25 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PLC BETA MEDIATED EVENTS | 43 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | 18 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 34 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY PDGF | 122 | 93 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 95 | 76 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 43 | 28 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION | 93 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 100 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 54 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 51 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 44 | 30 | All SZGR 2.0 genes in this pathway |
| 巨核细胞发育和血小板产生涉及的反应组因素 | 132 | 101 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR | 112 | 80 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 20 HELA | 11 | 8 | All SZGR 2.0 genes in this pathway |
| FERRANDO T ALL WITH MLL ENL FUSION UP | 87 | 67 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| GEISS RESPONSE TO DSRNA DN | 16 | 8 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| LEIN NEURON MARKERS | 69 | 45 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P4 | 100 | 62 | All SZGR 2.0 genes in this pathway |
| KONDO EZH2 TARGETS | 245 | 148 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
| ZHENG GLIOBLASTOMA PLASTICITY UP | 250 | 168 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP | 67 | 48 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING UP | 93 | 62 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |