Gene Page:PRKCA

Summary?
GeneID 5578
Symbol PRKCA
Synonyms AAG6|PKC-alpha|PKCA|PRKACA
Description protein kinase C alpha
Reference MIM:176960|HGNC:HGNC:9393|Ensembl:ENSG00000154229|HPRD:01498|Vega:OTTHUMG00000179533
Gene type protein-coding
Map location 17q24.2
Pascal p-value 0.463
Fetal beta -1.308
DMG 3 (# studies)
Support CANABINOID
我NTRACELLULAR SIGNAL TRANSDUCTION
METABOTROPIC GLUTAMATE RECEPTOR
SEROTONIN
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description 我nfo
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 2.2158

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09146232 17 64672129 PRKCA 5.325E-4 0.668 0.048 DMG:Wockner_2014
cg00050312 17 64299065 PRKCA -0.027 0.29 DMG:Nishioka_2013
cg00050312 17 64299065 PRKCA 1.67E-9 -0.032 1.48E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
我FNAR1 0.87 0.89
HOOK3 0.86 0.87
XIAP 0.85 0.87
TRIP11 0.84 0.84
KIAA0232 0.83 0.85
KIAA1704 0.82 0.83
FMR1 0.81 0.82
RANBP2 0.81 0.83
DNAJC13 0.81 0.83
ATP11B 0.81 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.55 -0.58
AF347015.21 -0.54 -0.54
METRN -0.54 -0.58
ENHO -0.53 -0.65
HIGD1B -0.53 -0.58
MT-CO2 -0.53 -0.56
AC131097.1 -0.51 -0.56
我FI27 -0.51 -0.55
FXYD1 -0.50 -0.52
CST3 -0.50 -0.54

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding 我EA -
GO:0004698 calcium-dependent protein kinase C activity 我EA -
GO:0005509 calcium ion binding 我EA -
GO:0005515 protein binding 我PI 12893243
GO:0005524 ATP binding 我EA -
GO:0016740 transferase activity 我EA -
GO:0008270 zinc ion binding 我EA -
GO:0019992 二酰基甘油绑定 我EA -
GO:0046872 metal ion binding 我EA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000188 inactivation of MAPK activity 我EA -
GO:0002062 chondrocyte differentiation 我EA -
GO:0002026 regulation of the force of heart contraction 我EA -
GO:0001933 negative regulation of protein amino acid phosphorylation 我EA -
GO:0001934 positive regulation of protein amino acid phosphorylation 我EA -
GO:0006469 negative regulation of protein kinase activity 我EA -
GO:0007242 intracellular signaling cascade 我EA -
GO:0008629 induction of apoptosis by intracellular signals 我EA -
GO:0006937 regulation of muscle contraction 我EA -
GO:0008624 induction of apoptosis by extracellular signals TAS 10825394
GO:0006874 cellular calcium ion homeostasis 我EA -
GO:0050930 induction of positive chemotaxis 我EA -
去:0030593 neutrophil chemotaxis 我EA -
GO:0050729 positive regulation of inflammatory response 我EA -
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 我EA -
GO:0046325 negative regulation of glucose import 我EA -
GO:0046627 negative regulation of insulin receptor signaling pathway 我EA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 9814702
GO:0005829 cytosol 我DA 17983652
GO:0005624 membrane fraction 我DA 17983652
GO:0005634 nucleus 我EA -
GO:0005737 cytoplasm 我EA -
GO:0005739 mitochondrion 我EA -
GO:0005886 plasma membrane EXP 9814702|10194441|10856305

Section IV. Protein-protein interaction annotation

我nteractors Aliases B Official full name B Experimental Source PubMed ID
ACTA1 ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3 actin, alpha 1, skeletal muscle - HPRD,BioGRID 10628374
ADAP1 CENTA1 | GCS1L | p42IP4 ArfGAP with dual PH domains 1 - HPRD 12893243
ADCY5 AC5 adenylate cyclase 5 - HPRD 7759492|8206971
AFAP1 AFAP | AFAP-110 | FLJ56849 actin filament associated protein 1 - HPRD,BioGRID 12134071
AKAP12 AKAP250 | DKFZp686M0430 | DKFZp686O0331 | FLJ20945 | FLJ97621 一个激酶(PRKA)锚蛋白12 - HPRD,BioGRID 11316952
AKAP13 AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31| LBC | PROTO-LB | PROTO-LBC | c-lbc 一个激酶(PRKA)anchor protein 13 AKAP-Lbc interacts with PKC-alpha. This interaction was modeled on a demonstrated interaction between human AKAP-Lbc and rat PKC-alpha. BIND 15383279
ARHGEF1 GEF1 | LBCL2 | LSC | P115-RHOGEF | SUB1.5 Rho guanine nucleotide exchange factor (GEF) 1 - HPRD 12754211
ATP1A1 MGC3285 | MGC51750 ATPase, Na+/K+ transporting, alpha 1 polypeptide Biochemical Activity BioGRID 15069082
AVPR1A AVPR1 arginine vasopressin receptor 1A - HPRD,BioGRID 10858434
AVPR1B AVPR3 arginine vasopressin receptor 1B Affinity Capture-Western BioGRID 10858434
AVPR2 ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2R arginine vasopressin receptor 2 Affinity Capture-Western BioGRID 10858434
C1QBP GC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32 complement component 1, q subcomponent binding protein - HPRD,BioGRID 10831594
CD9 5H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29 CD9 molecule - HPRD,BioGRID 11325968
CDC42 CDC42Hs | G25K cell division cycle 42 (GTP binding protein, 25kDa) - HPRD,BioGRID 11284700
DGKZ DAGK5 | DAGK6 | DGK-ZETA | hDGKzeta diacylglycerol kinase, zeta 104kDa - HPRD 12890670
DLG4 FLJ97752 | FLJ98574 | PSD95 | SAP90 discs, large homolog 4 (Drosophila) - HPRD,BioGRID 11937501
EGFR ERBB | ERBB1 | HER1 | PIG61 | mENA epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) - HPRD,BioGRID 12878187
EZR CVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2 ezrin - HPRD,BioGRID 11387207
FSCN1 FLJ38511 | SNL | p55 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) - HPRD,BioGRID 14532112
GABRB3 ECA5 | MGC9051 gamma-aminobutyric acid (GABA) A receptor, beta 3 Reconstituted Complex BioGRID 12595241
GABRR2 - gamma-aminobutyric acid (GABA) receptor, rho 2 - HPRD 9839716
GJA1 CX43 | DFNB38 | GJAL | ODDD gap junction protein, alpha 1, 43kDa - HPRD,BioGRID 11273731
GNA12 MGC104623 | MGC99644 | NNX3 | RMP | gep guanine nucleotide binding protein (G protein) alpha 12 - HPRD 8647866
GNB2L1 Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Affinity Capture-Western BioGRID 12435334
GRM7 FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7 glutamate receptor, metabotropic 7 Affinity Capture-Western BioGRID 11007882
GSK3B - glycogen synthase kinase 3 beta Biochemical Activity BioGRID 1324914
HABP4 我HABP4 | Ki-1/57 | MGC825 | SERBP1L hyaluronan binding protein 4 - HPRD,BioGRID 14699138
HAND1 Hxt | Thing1 | bHLHa27 | eHand heart and neural crest derivatives expressed 1 Biochemical Activity BioGRID 14636580
HAND2 DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHand heart and neural crest derivatives expressed 2 - HPRD,BioGRID 14636580
我TGB1 CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) - HPRD,BioGRID 12138200
我TPKB 我P3K | IP3K-B | IP3KB | PIG37 inositol 1,4,5-trisphosphate 3-kinase B in vitro BioGRID 9374536
KCNE4 MGC20353 | MIRP3 potassium voltage-gated channel, Isk-related family, member 4 - HPRD 12670483
KLF5 BTEB2 | CKLF | IKLF Kruppel-like factor 5 (intestinal) Biochemical Activity BioGRID 12682370
LMNA CDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1 lamin A/C - HPRD,BioGRID 12112001
LMNB1 ADLD | LMN | LMN2 | LMNB | MGC111419 lamin B1 - HPRD,BioGRID 11901153|12135703
MBP MGC99675 myelin basic protein PKC-alpha phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-alpha and MBP, both from unspecified species. BIND 10383403
MGMT - O-6-methylguanine-DNA methyltransferase Biochemical Activity BioGRID 10667577
MYLK DKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCK myosin light chain kinase - HPRD 3160694
OGG1 HMMH | HOGG1 | MUTM | OGH1 8-oxoguanine DNA glycosylase - HPRD,BioGRID 12034821
PDLIM7 LMP1 PDZ and LIM domain 7 (enigma) - HPRD 8940095
PEBP1 HCNP | PBP | PEBP | RKIP phosphatidylethanolamine binding protein 1 PKCalpha interacts with and phosphorylates RKIP. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human PKCalpha. BIND 14654844
PICK1 MGC15204 | PICK | PRKCABP protein interacting with PRKCA 1 Affinity Capture-Western BioGRID 11007882
PLD1 - phospholipase D1, phosphatidylcholine-specific - HPRD,BioGRID 12839565
PLD2 - phospholipase D2 - HPRD,BioGRID 11042115
PPP1R14A CPI-17 | CPI17 | PPP1INL protein phosphatase 1, regulatory (inhibitor) subunit 14A - HPRD 15003508
RAC1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) - HPRD,BioGRID 11284700
RGS2 G0S8 regulator of G-protein signaling 2, 24kDa - HPRD,BioGRID 11063746
RHOA ARH12 | ARHA | RHO12 | RHOH12 ras homolog gene family, member A in vivo BioGRID 11284700
SDPR PS-p68 | SDR serum deprivation response (phosphatidylserine binding protein) - HPRD 9566962
SELL CD62L | LAM-1 | LAM1 | LECAM1 | LNHR | LSEL | LYAM1 | Leu-8 | Lyam-1 | PLNHR | TQ1 | hLHRc selectin L L-selectin interacts with PKC-alpha. BIND 15192100
SEMG1 MGC14719 | SEMG | SGI semenogelin I - HPRD 12399526
SLC1A1 EAAC1 | EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 - HPRD,BioGRID 12843260
STXBP3 MUNC18-3 | MUNC18C | PSP | UNC-18C syntaxin binding protein 3 - HPRD 10194441
TEP1 TLP1 | TP1 | TROVE1 | VAULT2 | p240 telomerase-associated protein 1 - HPRD 9837921
TERT EST2 | TCS1 | TP2 | TRT | hEST2 telomerase reverse transcriptase - HPRD 9837921
TIAM1 FLJ36302 T-cell lymphoma invasion and metastasis 1 - HPRD,BioGRID 10212259
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD 9935181
TRIM29 ATDC | FLJ36085 tripartite motif-containing 29 - HPRD 7644499
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide - HPRD,BioGRID 10433554
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide - HPRD,BioGRID 11950841


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway 我nfo
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 All SZGR 2.0 genes in this pathway
KEGG霍乱弧菌感染 56 32 All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 59 36 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG GLIOMA 65 56 All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 54 47 All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY 11 9 All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 36 28 All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY 22 15 All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY 22 18 All SZGR 2.0 genes in this pathway
BIOCARTA AGPCR PATHWAY 13 12 All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 37 28 All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 45 35 All SZGR 2.0 genes in this pathway
BIOCARTA CDMAC PATHWAY 16 15 All SZGR 2.0 genes in this pathway
BIOCARTA CBL PATHWAY 13 10 All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY 24 22 All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY 21 17 All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY 31 25 All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 46 38 All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 31 24 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY 24 21 All SZGR 2.0 genes in this pathway
BIOCARTA ARENRF2 PATHWAY 13 9 All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY 20 16 All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY 27 24 All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 31 22 All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY 18 16 All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY 23 16 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 49 37 All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY 18 15 All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 37 28 All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY 24 17 All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY 27 25 All SZGR 2.0 genes in this pathway
BIOCARTA TRKA PATHWAY 12 10 All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY 29 18 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY 23 20 All SZGR 2.0 genes in this pathway
PID RET PATHWAY 39 29 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY 32 25 All SZGR 2.0 genes in this pathway
PID一TF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 30 23 All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 34 26 All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 26 23 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
PID一6B1 A6B4 INTEGRIN PATHWAY 46 35 All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY 28 19 All SZGR 2.0 genes in this pathway
PID RAS PATHWAY 30 22 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 78 59 All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF KIT SIGNALING 17 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE 11 9 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 16 11 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP 59 38 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP 82 51 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP 130 85 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN 84 54 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 87 48 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
GOUYER TATI TARGETS UP 10 7 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 UP 17 11 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN 52 35 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
我VANOVA HEMATOPOIESIS STEM CELL SHORT TERM 32 15 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 36 24 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP 36 24 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 50 35 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MF DN 41 28 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-150 802 808 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-183 826 832 m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-200bc/429 1319 1325 1A hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 752 758 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-326 366 372 1A hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-362 762 769 1A,m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p 1320 1327 1A,m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-539 4312 4318 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-9 5337 5343 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA