Gene Page:MYO5C

Summary?
GeneID 55930
Symbol MYO5C
Synonyms -
Description myosin VC
Reference MIM:610022|HGNC:HGNC:7604|Ensembl:ENSG00000128833|HPRD:11380|Vega:OTTHUMG00000172630
Gene type protein-coding
Map location 15q21
Pascal p-value 0.146
Sherlock p-value 0.016
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07567679 15 52570612 MIR1266;MYO5C 2.621E-4 0.561 0.038 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17572651 chr1 218943612 MYO5C 55930 0.13 trans
rs16829545 chr2 151977407 MYO5C 55930 5.986E-12 trans
rs3845734 chr2 171125572 MYO5C 55930 0 trans
rs7584986 chr2 184111432 MYO5C 55930 2.536E-7 trans
rs2183142 chr4 159232695 MYO5C 55930 0.15 trans
rs17762315 chr5 76807576 MYO5C 55930 0 trans
rs3118341 chr9 25185518 MYO5C 55930 0.03 trans
rs17176921 chr10 50580874 MYO5C 55930 0.15 trans
rs2393316 chr10 59333070 MYO5C 55930 0.05 trans
rs16955618 chr15 29937543 MYO5C 55930 2.293E-17 trans
rs12914345 chr15 77670400 MYO5C 55930 0.17 trans
rs1041786 chr21 22617710 MYO5C 55930 0 trans
rs16986332 chrX 10958354 MYO5C 55930 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C7orf57 0.98 0.45
SPATA18 0.98 0.45
YSK4 0.98 0.48
ARMC3 0.98 0.56
SPAG6 0.97 0.62
RGS22 0.97 0.53
CCDC108 0.97 0.53
VWA3B 0.97 0.50
ARMC4 0.97 0.46
TEKT1 0.97 0.44
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IER5L -0.13 -0.19
CIDEA -0.12 -0.12
NDRG1 -0.12 -0.03
EMX1 -0.11 -0.20
SLC26A4 -0.11 -0.09
GPR22 -0.10 -0.15
GPR21 -0.10 -0.07
MPPED1 -0.10 -0.14
MEF2C -0.10 -0.05
DUSP1 -0.10 0.02

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KIM RESPONSE TO TSA AND DECITABINE UP 129 73 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242 165 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 95 57 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS DN 29 18 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN 114 58 All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK UP 27 15 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 59 32 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 59 44 All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL UP 39 17 All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 78 49 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 167 99 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11 36 24 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 113 70 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 17 11 All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP 193 95 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
VANDESLUIS NORMAL EMBRYOS DN 25 13 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 All SZGR 2.0 genes in this pathway