Summary
基因 5594
Symbol MAPK1
Synonyms ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
Description 有丝分裂原激活的蛋白激酶1
Reference MIM:176948|HGNC:HGNC:6871|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508
Gene type 蛋白质编码
Map location 22q11.21
Pascal p-value 0.002
Sherlock p-value 0.481
胎儿β -1.658
主持人 Myers' cis & trans
Support CANABINOID
INTRACELLULAR SIGNAL TRANSDUCTION
METABOTROPIC GLUTAMATE RECEPTOR
5-羟色胺
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2CDB.HUMANNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.031
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias 点击显示详细信息
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1451

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
rs10504300 chr8 60714730 MAPK1 5594 0.12 trans
RS493713 chr8 60882998 MAPK1 5594 0.16 trans

第二节。转录组注释

一般基因表达(GTEX)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0004707 MAP激酶活性 TAS 10706854
GO:0001784 磷酸酪氨酸结合 IEA -
去:0005515 蛋白质结合 IPI 9632734|16286470|16291755
去:0005524 ATP binding IEA -
去:0004674 protein serine/threonine kinase activity EXP 16626623
去:0004674 protein serine/threonine kinase activity IEA -
GO:0016740 转移酶活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007268 synaptic transmission TAS 神经元,突触,神经递质(GO期限:6) 10051431
GO:0000165 MAPKKK cascade IEA -
去:0006468 protein amino acid phosphorylation IEA -
GO:0007265 Ras protein signal transduction EXP 11520933
GO:0006917 诱导凋亡 TAS 10958679
GO:0009887 organ morphogenesis IEA -
GO:0007049 cell cycle IEA -
GO:0019858 胞嘧啶代谢过程 IEA -
GO:0006974 response to DNA damage stimulus IEA -
GO:0006935 chemotaxis TAS 10706854
GO:0032496 对脂多糖的反应 IEA -
GO:0031663 lipopolysaccharide-mediated signaling pathway IEA -
GO:0043330 response to exogenous dsRNA IEA -
GO:0044419 interspecies interaction between organisms IEA -
GO:0045596 negative regulation of cell differentiation IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 cytosol EXP 10066798|10878576
GO:0005856 细胞骨架 IDA 18029348
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm EXP 9687510|16456541|16626623
|17322878
去:0005730 nucleolus IDA 18029348
去:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B 实验 Source PubMed ID
ADAM17 CD156b | MGC71942 | TACE | cSVP ADAM metallopeptidase domain 17 亲和力捕获 - 韦斯特恩
生化活动
重构的复合物
Biogrid 12058067
ar AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM 雄激素受体 重构的复合物 Biogrid 10318905
ATF2 CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7 activating transcription factor 2 生化活动 Biogrid 7737129
ATP1A1 MGC3285 | MGC51750 ATPase, Na+/K+ transporting, alpha 1 polypeptide 生化活动 Biogrid 15069082
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD 15225643
C1QBP GC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32 complement component 1, q subcomponent binding protein - HPRD,BioGRID 11866440
CALCOCO1 Cocoa | KIAA1536 | PP13275 | calphoglin calcium binding and coiled-coil domain 1 KIAA1536 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species. BIND 15489336
CASP9 APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6 caspase 9, apoptosis-related cysteine peptidase - HPRD,BioGRID 12792650
CEBPB C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 CCAAT/enhancer binding protein (C/EBP), beta 生化活动 Biogrid 11500490
DAPK1 DAPK | DKFZp781I035 death-associated protein kinase 1 DAPK interacts with Erk2. BIND 15616583
DUSP1 CL100 | HVH1 | MKP-1 | MKP1 | PTPN10 双重特异性磷酸酶1 - HPRD,BioGRID 11278799
DUSP16 KIAA1700 | MGC129701 | MGC129702 | MKP-7 | MKP7 双重特异性磷酸酶16 - HPRD,BioGRID 11489891
DUSP22 JKAP | JSP1 | MKPX | VHX dual specificity phosphatase 22 亲和力捕获 - 韦斯特恩
生化活动
Biogrid 11346645
dusp3 VHR 双重特异性磷酸酶3 - HPRD,BioGRID 10224087
DUSP4 HVH2 | MKP-2 | MKP2 | TYP 双重特异性磷酸酶4 - HPRD 7535768
DUSP6 MKP3 | PYST1 双重特异性磷酸酶6 - HPRD,BioGRID 9535927
DUSP6 MKP3 | PYST1 双重特异性磷酸酶6 - HPRD 9535927|15269220
DYRK1B MIRK dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B - HPRD,BioGRID 10910078
ELK1 - ELK1, member of ETS oncogene family Mapk1 phosphory (p42Mapk)lates Elk1 at Ser383. BIND 15782123
ELK1 - ELK1, member of ETS oncogene family - HPRD 8208531|8586671
ELK1 - ELK1, member of ETS oncogene family 生化活动
重构的复合物
Biogrid 8586671|12594221
EPOR MGC138358 erythropoietin receptor - HPRD 12538595
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 - HPRD,BioGRID 12093745
FHL2 AAG11 |Dral |Slim3 four and a half LIM domains 2 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid
Biogrid 14729955
FHL3 MGC19547 | MGC23614 | MGC8696 | SLIM2 four and a half LIM domains 3 - HPRD 14729955
GATA4 MGC126629 GATA binding protein 4 生化活动 Biogrid 11585926
GMFB GMF glia maturation factor, beta - HPRD 8639570
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 - HPRD,BioGRID 11114188
HMMR CD168 |ihabp |MGC119494 |MGC119495 |Rhamm 透明质酸介导的运动受体(RHAMM) 亲和力捕获 - 韦斯特恩 Biogrid 11403955
HSP90AA1 FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 - HPRD 11748628
IER3 DIF-2 | DIF2 | GLY96 | IEX-1 | IEX-1L | IEX1 | PRG1 immediate early response 3 生化活动 Biogrid 12356731
IFNAR1 AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC interferon (alpha, beta and omega) receptor 1 - HPRD 9029147
INSR CD220 | HHF5 insulin receptor 亲和力捕获 - 韦斯特恩 Biogrid 11409918
KLF11 FKLF | FKLF1 | MODY7 | TIEG2 | Tieg3 Kruppel-like factor 11 - HPRD 12006497
KSR2 FLJ25965 kinase suppressor of ras 2 - HPRD 12975377
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 MEK1 interacts with and phosphorylates ERK2. This interaction is modeled on a demonstrated interaction between human MEK1 and rat ERK2. BIND 11134045
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 亲和力捕获 - 韦斯特恩
生化活动
重构的复合物
Two-hybrid
Biogrid 10757792|11266467
|11279118|11352917
|11823456|12697810
MAP2K2 FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2 mitogen-activated protein kinase kinase 2 MEK2 interacts with ERK2. This interaction is modeled on a demonstrated interaction between human MEK2 and rat ERK2. BIND 11134045
MAP2K2 FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2 mitogen-activated protein kinase kinase 2 - HPRD,BioGRID 11823456
MAP3K1 MAPKKK1 | MEKK | MEKK1 有丝分裂原激活的蛋白激酶激酶激酶1 亲和力捕获 - 韦斯特恩 Biogrid 10969079
MAP3K1 MAPKKK1 | MEKK | MEKK1 有丝分裂原激活的蛋白激酶激酶激酶1 MEKK1 interacts with ERK2. BIND 10969079
MAPK14 CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHA 有丝分裂原激活的蛋白激酶14 - HPRD,BioGRID 12697810
MAPKAPK2 MK2 有丝分裂原激活的蛋白激酶激活的蛋白激酶2 亲和力捕获 - 韦斯特恩 Biogrid 15094067
MAPKAPK5 prak 有丝分裂原激活的蛋白激酶激活的蛋白激酶5 - HPRD 9628874
MAPKSP1 MAP2K1IP1 | MAPBP | MP1 MAPK scaffold protein 1 - HPRD,BioGRID 11266467
MBP MGC99675 myelin basic protein MBPinteracts with MAPK1. This interaction was modeled on a demonstrated interaction between MBP from an unspecified species, and monkey and mouse MAPK1. BIND 9792705
MKNK1 MNK1 MAP kinase interacting serine/threonine kinase 1 重构的复合物
Two-hybrid
Biogrid 9155017
MKNK2 GPRK7 | MNK2 MAP kinase interacting serine/threonine kinase 2 - HPRD,BioGRID 9155017
MYC Bhlhe39 |c-myc v-myc myelocytomatosis viral oncogene homolog (avian) 生化活动
重构的复合物
Biogrid 7957875|9207092
|15210690
NEK2 HsPK21 | NEK2A | NLK1 NIMA (never in mitosis gene a)-related kinase 2 - HPRD,BioGRID 15358203
PEA15 HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PED phosphoprotein enriched in astrocytes 15 - HPRD,BioGRID 11702783
PEBP1 HCNP | PBP | PEBP | RKIP phosphatidylethanolamine binding protein 1 - HPRD,BioGRID 10757792
PECAM1 CD31 | PECAM-1 platelet/endothelial cell adhesion molecule 亲和力捕获 - 韦斯特恩 Biogrid 10801826
PLAT DKFZp686I03148 | T-PA | TPA plasminogen activator, tissue - HPRD 15861134
PRKCE MGC125656 |MGC125657 |PKCE |npkc-epsilon protein kinase C, epsilon 亲和力捕获 - 韦斯特恩 Biogrid 11350735
PTPN5 FLJ14427 | PTPSTEP | STEP protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 重构的复合物 Biogrid 9857190
PTPN7 BPTP-4 | HEPTP | LC-PTP | LPTP | PTPNI protein tyrosine phosphatase, non-receptor type 7 - HPRD,BioGRID 10206983|10702794
PTPRH FLJ39938 | MGC133058 | MGC133059 | SAP-1 蛋白酪氨酸磷酸酶,受体类型,H - HPRD 11278335
PTPRR DKFZp781C1038 | EC-PTP | FLJ34328 | MGC131968 | MGC148170 | PCPTP1 | PTP-SL | PTPBR7 | PTPRQ 蛋白酪氨酸磷酸酶,受体类型,R - HPRD,BioGRID 9857190
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 亲和力捕获 - 韦斯特恩 Biogrid 11409918
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 RAF-1与ERK2相互作用。这种相互作用是基于未指定物种的人RAF-1和ERK2之间的相互作用建模的。 BIND 15664191
RB1 OSRC |RB |P105-RB |PRB |PP110 retinoblastoma 1 RB1被MAPK1磷酸化。这种相互作用是基于未指定物种的人类KIAA1536和MAPK1之间的相互作用进行建模的。 BIND 15489336
RPS6KA1 HU-1 | MAPKAPK1A | RSK | RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 - HPRD,BioGRID 9915826|12594221
|12832467
RPS6KA2 HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3 ribosomal protein S6 kinase, 90kDa, polypeptide 2 RSK3与ERK2相互作用。这种相互作用是建立在人RSK3和猴子ERK2之间的相互作用上的模型。 BIND 9915826
RPS6KA2 HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3 ribosomal protein S6 kinase, 90kDa, polypeptide 2 - HPRD,BioGRID 8939914
RPS6KA3 CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 亲和力捕获 - 韦斯特恩 Biogrid 8939914|9915826
RPS6KA3 CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 - HPRD 12832467
RPS6KA4 MSK2 | RSK-B ribosomal protein S6 kinase, 90kDa, polypeptide 4 - HPRD 9687510
RPS6KA5 MGC1911 | MSK1 | MSPK1 | RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 Phenotypic Enhancement Biogrid 9687510
SHC1 人体自燃现象FLJ26504 | | SHCA SHC(SRC同源性2结构域)转化蛋白1 - HPRD,BioGRID 10996427
SNCA MGC110988 | NACP | PARK1 | PARK4 | PD1 synuclein, alpha (non A4 component of amyloid precursor) 亲和力捕获 - 韦斯特恩 Biogrid 12121974
SNCA MGC110988 | NACP | PARK1 | PARK4 | PD1 synuclein, alpha (non A4 component of amyloid precursor) - HPRD 11279280
SNCG BCSG1 |Sr synuclein, gamma (breast cancer-specific protein 1) 亲和力捕获 - 韦斯特恩 Biogrid 12121974
SORBS3 骗局1 |Scam1 |SH3D4 |葡萄蛋白 sorbin and SH3 domain containing 3 亲和力捕获 - 韦斯特恩
生化活动
Biogrid 15184391
SrEBF1 SrEBP-1c | SREBP1 | bHLHd1 sterol regulatory element binding transcription factor 1 生化活动 Biogrid 10627507
SrEBF2 SrEBP2 | bHLHd2 sterol regulatory element binding transcription factor 2 - HPRD,BioGRID 10627507
Stat5A MGF | STAT5 signal transducer and activator of transcription 5A - HPRD,BioGRID 10194762|10996427
Stat5B Stat5 signal transducer and activator of transcription 5B - HPRD 10996427
TH TYH tyrosine hydroxylase 生化活动 Biogrid 1347949
TNFSF11 CD254 |ODF |OPGL |OPTB2 |rankl |tr |hrankl2 |SODF tumor necrosis factor (ligand) superfamily, member 11 - HPRD 10635328
TNIP1 ABIN-1 | KIAA0113 | NAF1 | VAN TNFAIP3相互作用蛋白1 Naf1-alpha interacts with ERK2. BIND 12220502
TNIP1 ABIN-1 | KIAA0113 | NAF1 | VAN TNFAIP3相互作用蛋白1 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid
Biogrid 12220502
TNKS2 PARP-5b | PARP-5c | PARP5B | PARP5C | TANK2 | TNKL tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 生化活动 Biogrid 10988299
TOB1 APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1 transducer of ERBB2, 1 - HPRD,BioGRID 12151396
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 亲和力捕获 - 韦斯特恩 Biogrid 10958792
TPR - translocated promoter region (to activated MET oncogene) - HPRD,BioGRID 12594221
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 亲和力捕获 - 韦斯特恩
重构的复合物
Biogrid 15851026
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 Erk2 interacts with TSC2. This interaction was modelled on a demonstrated interaction between Erk2 from an unspecified species and human TSC2. BIND 15851026
UBR5 DD5 |EDD |EDD1 |FLJ11310 |hyd |KIAA0896 |MGC57263 ubiquitin protein ligase E3 component n-recognin 5 - HPRD,BioGRID 12594221
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 - HPRD,BioGRID 8900182|9013873
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 Vav interacts with ERK2. BIND 9013873


Section V. Pathway annotation

Pathway name 路径大小 # SZGR 2.0 genes in pathway 信息
kegg mapk信号通路 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG趋化因子信号传导途径 190 128 All SZGR 2.0 genes in this pathway
Kegg卵母细胞减数分裂 114 79 All SZGR 2.0 genes in this pathway
kegg mtor信号通路 52 40 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG DORSO VENTRAL AXIS FORMATION 25 21 All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 75 53 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG点头像受体信号通路 62 47 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
kegg fc epsilon ri信号传导途径 79 58 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟 86 59 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS 47 41 All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 35 28 All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 72 56 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 62 47 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤 65 56 All SZGR 2.0 genes in this pathway
KEGG前列腺癌 89 75 All SZGR 2.0 genes in this pathway
KEGG甲状腺癌 29 26 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
Kegg膀胱癌 42 33 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
Kegg急性髓样白血病 60 47 All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 54 47 All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 36 31 All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 36 28 All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY 22 18 All SZGR 2.0 genes in this pathway
生物卡丁生物肽途径 45 35 All SZGR 2.0 genes in this pathway
Biocarta CDMAC途径 16 15 All SZGR 2.0 genes in this pathway
Biocarta CCR3途径 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY 22 16 All SZGR 2.0 genes in this pathway
Biocarta CXCR4途径 24 22 All SZGR 2.0 genes in this pathway
Biocarta ECM途径 24 17 All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 41 30 All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 39 29 All SZGR 2.0 genes in this pathway
Biocarta GH途径 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 34 28 All SZGR 2.0 genes in this pathway
BIOCARTA HCMV PATHWAY 17 16 All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY 38 26 All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY 26 23 All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 38 29 All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 46 38 All SZGR 2.0 genes in this pathway
Biocarta Pyk2途径 31 24 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY 25 16 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY 23 20 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA ARENRF2 PATHWAY 13 9 All SZGR 2.0 genes in this pathway
Biocarta EDG1途径 27 24 All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY 11 11 All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY 18 14 All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY 26 23 All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY 22 17 All SZGR 2.0 genes in this pathway
Biocarta ERK5途径 18 15 All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
Biocarta Barr MAPK途径 12 11 All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY 15 14 All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 37 30 All SZGR 2.0 genes in this pathway
Biocarta Spry途径 18 15 All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY 27 25 All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY 21 15 All SZGR 2.0 genes in this pathway
PC12细胞中的ST分化途径 45 35 All SZGR 2.0 genes in this pathway
SA B细胞受体复合物 24 20 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP 34 28 All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 23 16 All SZGR 2.0 genes in this pathway
st g alpha的路径 16 11 All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY 35 29 All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES 27 23 All SZGR 2.0 genes in this pathway
ST颗粒细胞存活途径 27 23 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
ST整合素信号通路 82 62 All SZGR 2.0 genes in this pathway
心肌细胞中的SIG胰岛素受体途径 51 41 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY 27 25 All SZGR 2.0 genes in this pathway
SA PTEN PATHWAY 17 14 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID内皮素路径 63 52 All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 65 50 All SZGR 2.0 genes in this pathway
PID PRL信号事件途径 23 17 All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY 38 32 All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 37 31 All SZGR 2.0 genes in this pathway
PID MET PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 29 24 All SZGR 2.0 genes in this pathway
PID EPHB FWD途径 40 38 All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY 31 29 All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY 14 11 All SZGR 2.0 genes in this pathway
PID PS1途径 46 39 All SZGR 2.0 genes in this pathway
PID步道路径 28 20 All SZGR 2.0 genes in this pathway
PID CDC42途径 70 51 All SZGR 2.0 genes in this pathway
PID RET路径 39 29 All SZGR 2.0 genes in this pathway
PID血管生成素受体途径 50 41 All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY 21 18 All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 68 48 All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 32 27 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 15 14 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 35 29 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID神经酰胺途径 48 37 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 40 34 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 44 35 All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 42 31 All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY 26 21 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
PID SYNDECAN 1 PATHWAY 46 29 All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 30 23 All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 31 27 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 26 23 All SZGR 2.0 genes in this pathway
PID SMAD2 3 Pathway 17 13 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID Syndecan 2途径 33 27 All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 17 15 All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 34 31 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY 25 16 All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 33 25 All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 55 37 All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 59 45 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING 14 9 All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 24 19 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 37 24 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 22 20 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome SHC1事件 20 17 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
向ERK的Reactome信号传导 36 30 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 24 20 All SZGR 2.0 genes in this pathway
REACTOME ERKS ARE INACTIVATED 12 9 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING 15 13 All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS 21 17 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 33 28 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活 50 37 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS 10 8 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 20 All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 86 62 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 34 25 All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1 27 15 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 13 11 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
Reactome IL 2信号传导 41 34 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING 14 13 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE 10 10 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING 15 12 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome收费受体级联 118 84 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS 17 13 All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血髓样DN 38 25 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
Elvidge缺氧DN 146 94 All SZGR 2.0 genes in this pathway
Bidus转移 214 134 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 44 31 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 MCF10A 43 26 All SZGR 2.0 genes in this pathway
唱歌转移基质 110 70 All SZGR 2.0 genes in this pathway
CHESLER BRAIN D6MIT150 QTL TRANS 9 7 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
TACI UP淋巴细胞的淋巴细胞成熟 92 58 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 71 49 All SZGR 2.0 genes in this pathway
伊万诺娃造血晚期祖先 544 307 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
Hedenfalk乳腺癌BRCA1与BRCA2 163 113 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
克拉斯的加沙表观遗传沉默 26 16 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14删除 74 40 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES 31 26 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
甜Kras致癌签名 89 56 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G23 UP 52 35 All SZGR 2.0 genes in this pathway
li诱导了自然杀手DN 116 83 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
棕熊UVC响应很晚 317 190 All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS 90 56 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-129-5p 3882 3888 1A HSA-MIR-129brain CUUUUUGCGGUCUGGGCUUGC
HSA-MIR-129-5p CUUUUUGCGGUCUGGGCUUGCU
mir-132/212 1379 1386 1A,m8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-181 3842 3848 m8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 3798 3804 m8 HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
mir-204/211 3259 3265 1A hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-214 1168 1174 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-217 305 311 m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
mir-320 652 658 m8 hsa-miR-320 aaaagcugggugagaggggcgaa
mir-326 184 190 1A hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
mir-330 3194 3200 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-34b 1594 1600 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
mir - 409 - 5p 964 970 1A HSA-MIR-409-5P AGGUUACCCGAGCAACUUUGCA
miR-493-5p 1642 1648 m8 HSA-MIR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-539 1530 1537 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
mir-543 3843 3849 m8 hsa-miR-543 aaacauucgcggugcacuucu