Gene Page:MAPK11
Summary?
| GeneID | 5600 |
| Symbol | MAPK11 |
| Synonyms | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta |
| Description | mitogen-activated protein kinase 11 |
| Reference | MIM:602898|HGNC:HGNC:6873|Ensembl:ENSG00000185386|HPRD:04208|Vega:OTTHUMG00000150226 |
| Gene type | protein-coding |
| Map location | 22q13.33 |
| Pascal p-value | 0.012 |
| Sherlock p-value | 0.05 |
| Fetal beta | 0.044 |
| eGene | Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| KEGG VEGF SIGNALING PATHWAY | 76 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | 102 | 88 | All SZGR 2.0 genes in this pathway |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | 62 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | 71 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
| KEGG FC EPSILON RI SIGNALING PATHWAY | 79 | 58 | All SZGR 2.0 genes in this pathway |
| KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG GNRH SIGNALING PATHWAY | 101 | 77 | All SZGR 2.0 genes in this pathway |
| KEGG PROGESTERONE MEDIATED OOCYTE MATURATION | 86 | 59 | All SZGR 2.0 genes in this pathway |
| KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS | 53 | 43 | All SZGR 2.0 genes in this pathway |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NTHI PATHWAY | 24 | 20 | All SZGR 2.0 genes in this pathway |
| SIG CD40PATHWAYMAP | 34 | 28 | All SZGR 2.0 genes in this pathway |
| ST P38 MAPK PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| PID P73PATHWAY | 79 | 59 | All SZGR 2.0 genes in this pathway |
| PID P38 MKK3 6PATHWAY | 26 | 21 | All SZGR 2.0 genes in this pathway |
| PID ER NONGENOMIC PATHWAY | 41 | 35 | All SZGR 2.0 genes in this pathway |
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| PID P38 ALPHA BETA PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
| PID FAS PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| PID TXA2PATHWAY | 57 | 43 | All SZGR 2.0 genes in this pathway |
| PID REG GR PATHWAY | 82 | 60 | All SZGR 2.0 genes in this pathway |
| PID IL2 1PATHWAY | 55 | 43 | All SZGR 2.0 genes in this pathway |
| PID ATF2 PATHWAY | 59 | 43 | All SZGR 2.0 genes in this pathway |
| PID IL6 7 PATHWAY | 47 | 40 | All SZGR 2.0 genes in this pathway |
| PID P38 MK2 PATHWAY | 21 | 19 | All SZGR 2.0 genes in this pathway |
| PID CXCR3 PATHWAY | 43 | 34 | All SZGR 2.0 genes in this pathway |
| PID P38 ALPHA BETA DOWNSTREAM PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| PID VEGFR1 2 PATHWAY | 69 | 57 | All SZGR 2.0 genes in this pathway |
| PID LYMPH ANGIOGENESIS PATHWAY | 25 | 16 | All SZGR 2.0 genes in this pathway |
| PID RB 1PATHWAY | 65 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING TO RAS | 27 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING TO ERKS | 36 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME P38MAPK EVENTS | 13 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 24 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME ERK MAPK TARGETS | 21 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME MYOGENESIS | 28 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 50 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | 10 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 30 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 18 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 77 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 17 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 72 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME DSCAM INTERACTIONS | 11 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 83 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TLR4 SIGNALLING | 93 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME TOLL RECEPTOR CASCADES | 118 | 84 | All SZGR 2.0 genes in this pathway |
| REACTOME NOD1 2 SIGNALING PATHWAY | 30 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 46 | 33 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| BUSA SAM68 TARGETS UP | 7 | 6 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| FURUKAWA DUSP6 TARGETS PCI35 UP | 74 | 32 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 22Q13 AMPLICON | 17 | 15 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |