基因页：MAP2K1

Summary？
基因 5604
Symbol MAP2K1
Synonyms CFC3|MAPKK1|MEK1|MKK1|PRKMK1
Description mitogen-activated protein kinase kinase 1
参考erence MIM：176872|HGNC:HGNC:6840|HPRD：01469|
Gene type 蛋白质编码
Map location 15q22.1-q22.33
Pascal p-value 0.622
Sherlock p-value 0.245
胎儿β -2.204
DMG 1(# studies)
支持 CANABINOID
DOPAMINE
INTRACELLULAR SIGNAL TRANSDUCTION
METABOTROPIC GLUTAMATE RECEPTOR
5-羟色胺
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2CDB.HUMANNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1
go_annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@DNMtable

Gene Chromosome Position 参考 alt transcript AA change Mutation type 筛 CG46 trait 学习
MAP2K1 CHR15 66774256 G t 内含子内部 intronic Schizophrenia DNM:Awadalla_2010

@差异甲基化基因

Probe Chromosome Position 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
cg00319686 15 66680551 MAP2K1 7.18e-5 0.897 0.025 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
the bar shown representes the lower 25% and upper 25% of the expression distribution.

top co-expressed genes in brain regions

前10个积极共表达的基因
Gene Pearson's Correlation Spearman's Correlation
PGD 0.97 0.93
RFWD2 0.97 0.94
EIF4A1 0.96 0.95
XRN2 0.96 0.93
tRAFD1 0.96 0.91
C12orf41 0.96 0.95
BZW2 0.96 0.93
KDM1 0.96 0.92
SIAH1 0.96 0.92
NARS2 0.96 0.94
top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HLA-F -0.76 -0.79
AF347015.27 -0.75 -0.90
AIFM3 -0.74 -0.78
AF347015.31 -0.74 -0.87
MT-CO2 -0.74 -0.89
AF347015.33 -0.74 -0.88
mt-cyb -0.73 -0.89
C5orf53 -0.72 -0.71
AF347015.8 -0.72 -0.89
AF347015.15 -0.71 -0.88

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0004708 MAP kinase kinase activity tAS 8388392
去：0005515 蛋白质结合 IPI 15299019
去：0005524 ATP结合 IEA -
去：0004674 protein serine/threonine kinase activity IEA -
GO:0004713 蛋白酪氨酸激酶活性 IEA -
GO:0016740 转移酶活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0030182 神经元分化 IEA neuron (GO term level: 8) -
去：0006468 protein amino acid phosphorylation IEA -
去：0007265 Ras protein signal transduction EXP 11520933
GO:0006935 chemotaxis tAS 10570282
GO:0006928 cell motion tAS 10912793
GO:0030216 keratinocyte differentiation IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B 实验 Source PubMed ID
阿拉夫 A-RAF | ARAF1 | PKS2 | RAFA1 V-RAF鼠肉瘤3611病毒癌基因同源物 MEK1 interacts with A-Raf. BIND 8621729
BRAF B-RAF1 |Braf1 |FLJ95109 |MGC126806 |MGC138284 |Rafb1 V-RAF鼠类肉瘤病毒癌基因同源物B1 MEK1 interacts with B-Raf. BIND 8621729
BRAF B-RAF1 |Braf1 |FLJ95109 |MGC126806 |MGC138284 |Rafb1 V-RAF鼠类肉瘤病毒癌基因同源物B1 - HPRD 7731720
CPNE1 COPN1 | CPN1 | MGC1142 copine I - HPRD 12522145
CPNE4 COPN4 |CPN4 |MGC15604 copine IV - HPRD 12522145
GRB10 GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSS growth factor receptor-bound protein 10 - HPRD,BioGRID 9553107
HRAS c-bas/has |C-H-Ras |C-HA-RAS1 |ctlo |H-Rasidx |hamsv |HRAS1 |k-ras |n-ras |Rash1 V-HA-RAS HARVEY RAT SARMA病毒性癌基因同源物 - HPRD,BioGRID 7969158
KSR2 FLJ25965 RAS 2的激酶抑制剂 - HPRD,BioGRID 12975377
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 生化活动 Biogrid 8226933
MAP3K1 mapkkk1 |mekk |mekk1 有丝分裂原激活的蛋白激酶激酶激酶1 亲和力捕获 - 韦斯特恩 Biogrid 10969079
MAP3K1 mapkkk1 |mekk |mekk1 有丝分裂原激活的蛋白激酶激酶激酶1 mekk1interacts with MEK1. BIND 10969079
MAP3K11 MGC17114 |MLK-3 |MLK3 |ptk1 |泉水 有丝分裂原激活的蛋白激酶激酶激酶11 MEK1 interacts with MLK3. BIND 15258589
MAP3K4 FLJ42439 | KIAA0213 | MAPKKK4 | MEKK4 | MTK1 | PRO0412 有丝分裂原激活的蛋白激酶激酶激酶4 - HPRD,BioGRID 9841871
MAP3K8 COT | EST | ESTF | FLJ10486 | TPL2 | Tpl-2 | c-COT 有丝分裂原激活的蛋白激酶激酶激酶8 生化活动 Biogrid 8631303
MAPK1 ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk 有丝分裂原激活的蛋白激酶1 MEK1 interacts with and phosphorylates ERK2. This interaction is modeled on a demonstrated interaction between human MEK1 and rat ERK2. BIND 11134045
MAPK1 ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk 有丝分裂原激活的蛋白激酶1 亲和力捕获 - 韦斯特恩
生化活动
重构的复合物
two-hybrid		 Biogrid 10757792|11266467
|11279118|11352917
|11823456|12697810
MAPK14 CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHA 有丝分裂原激活的蛋白激酶14 - HPRD 12697810
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 有丝分裂原激活的蛋白激酶3 亲和力捕获 - 韦斯特恩
生化活动
Co-localization
重构的复合物
two-hybrid		 Biogrid 8226933|8626767
|9006895|9733512
|10748187
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 有丝分裂原激活的蛋白激酶3 MEK1 interacts with ERK1 via a conserved docking site in MEK BIND 11134045
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 有丝分裂原激活的蛋白激酶3 - HPRD 8226933|8626767
|10748187
MAPK8IP3 DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2 有丝分裂原激活的蛋白激酶8相互作用蛋白3 - HPRD,BioGRID 10523642|11044439
MAPKSP1 MAP2K1IP1 | MAPBP | MP1 MAPK scaffold protein 1 - HPRD,BioGRID 9733512
MYC Bhlhe39 |c-myc v-myc myelocytomatosis viral oncogene homolog (avian) - HPRD 7957875
PEBP1 HCNP |PBP |PEBP |rkip phosphatidylethanolamine binding protein 1 - HPRD,BioGRID 10757792
PEBP4 软木1 |Cork1 |GWTM1933 |MGC22776 |Pro4408 phosphatidylethanolamine-binding protein 4 - HPRD,BioGRID 15302887
PEBP4 软木1 |Cork1 |GWTM1933 |MGC22776 |Pro4408 phosphatidylethanolamine-binding protein 4 hPEBP4 interacts with MEK1. This interaction was modeled on a demonstrated interaction between human hPEBP4 and mouse MEK1. BIND 15302887
PLAU atf |UPA |urk |尿激酶|U-PA 纤溶酶原激活剂，尿激酶 表型抑制 Biogrid 10402467
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 重构的复合物 Biogrid 10757792
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 Raf interacts with and phosphorylates Mek1 BIND 14724641
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 MEK1 interacts with and is phosphorylated by Raf-1. This interaction was modeled on a demonstrated interaction between human MEK1 and Raf-1 from an unspecified species. BIND 15866172
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 MEK1 interacts with c-Raf BIND 8621729
RAF1 克拉夫|NS5 |RAF-1 |C-Raf v-raf-1 murine leukemia viral oncogene homolog 1 - HPRD 11604401
Robld3 ENDAP | HSPC003 | MAPBPIP | MAPKSP1AP | p14 包含3的障碍域 亲和力捕获 - 韦斯特恩 Biogrid 11266467
RPS6KA2 HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3 ribosomal protein S6 kinase, 90kDa, polypeptide 2 - HPRD 8939914
tRAF3 CAP-1 |CD40BP |craf1 |LAP1 tNF receptor-associated factor 3 - HPRD 8626767
弗吉尼亚州V1 弗吉尼亚州V VAV 1鸟嘌呤核苷酸交换因子 亲和力捕获 - 韦斯特恩 Biogrid 8900182


Section V. Pathway annotation

Pathway name 路径大小 # SZGR 2.0 genes in pathway 信息
kegg mapk信号通路 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG趋化因子信号传导途径 190 128 All SZGR 2.0 genes in this pathway
Kegg卵母细胞减数分裂 114 79 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
kegg dorso腹轴形成 25 21 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
KEGG缝隙连接 90 68 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
kegg fc epsilon ri信号传导途径 79 58 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟 86 59 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 35 28 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 62 47 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤 65 56 All SZGR 2.0 genes in this pathway
KEGG前列腺癌 89 75 All SZGR 2.0 genes in this pathway
KEGG甲状腺癌 29 26 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
Kegg膀胱癌 42 33 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
Kegg急性髓样白血病 60 47 All SZGR 2.0 genes in this pathway
KEGG非小细胞肺癌 54 47 All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 36 28 All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY 22 18 All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 37 28 All SZGR 2.0 genes in this pathway
生物卡丁生物肽途径 45 35 All SZGR 2.0 genes in this pathway
Biocarta CDMAC途径 16 15 All SZGR 2.0 genes in this pathway
Biocarta CCR3途径 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY 22 16 All SZGR 2.0 genes in this pathway
Biocarta CXCR4途径 24 22 All SZGR 2.0 genes in this pathway
Biocarta EGF途径 31 25 All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY 19 13 All SZGR 2.0 genes in this pathway
Biocarta ECM途径 24 17 All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 41 30 All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 39 29 All SZGR 2.0 genes in this pathway
Biocarta GH途径 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA HCMV PATHWAY 17 16 All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY 21 16 All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY 22 16 All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY 15 11 All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY 22 16 All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY 23 17 All SZGR 2.0 genes in this pathway
生物卡塔胰岛素途径 22 16 All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 38 29 All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 46 38 All SZGR 2.0 genes in this pathway
Biocarta Pyk2途径 31 24 All SZGR 2.0 genes in this pathway
Biocarta EGFR Smrte途径 11 11 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY 23 20 All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY 18 13 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
Biocarta PDGF途径 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY 11 11 All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 23 20 All SZGR 2.0 genes in this pathway
Biocarta nkcells途径 20 13 All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY 22 17 All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
Biocarta Barr MAPK途径 12 11 All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY 15 14 All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 37 30 All SZGR 2.0 genes in this pathway
Biocarta GPCR途径 37 31 All SZGR 2.0 genes in this pathway
Biocarta Spry途径 18 15 All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 49 37 All SZGR 2.0 genes in this pathway
Biocarta TGFB途径 19 14 All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY 24 17 All SZGR 2.0 genes in this pathway
SA B细胞受体复合物 24 20 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR 17 15 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID内皮素路径 63 52 All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 65 50 All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 37 31 All SZGR 2.0 genes in this pathway
PID遇到了路径 80 60 All SZGR 2.0 genes in this pathway
PID EPHB FWD途径 40 38 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 32 27 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID神经酰胺途径 48 37 All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 40 34 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 44 35 All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID PDGFRB途径 129 103 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 31 27 All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 48 35 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 52 40 All SZGR 2.0 genes in this pathway
PID VEGFR1 2途径 69 57 All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 17 15 All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 34 31 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
PID FAK通路 59 45 All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导 217 167 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING 22 20 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome SHC1事件 20 17 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
Reactome Arms介导的激活 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 27 23 All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出 137 105 All SZGR 2.0 genes in this pathway
向ERK的Reactome信号传导 36 30 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING 15 13 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活 50 37 All SZGR 2.0 genes in this pathway
Reactome L1CAM相互作用 86 62 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 34 25 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
Reactome IL 2信号传导 41 34 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
Reactome SOS介导的信号传导 14 13 All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE 10 10 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING 15 12 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome收费受体级联 118 84 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS 17 13 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
Bogni治疗与髓样白血病有关 30 19 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS 148 97 All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE UP 90 62 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植OK vs捐助者 151 100 All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 88 64 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
伊万诺娃造血晚期祖先 544 307 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 58 43 All SZGR 2.0 genes in this pathway
周TNF信号30分钟 54 36 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
tRACEY RESISTANCE TO IFNA2 DN 32 23 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 47 31 All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 69 45 All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化 940 425 All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY 33 23 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
甜肺癌克拉斯 491 316 All SZGR 2.0 genes in this pathway
YIH对砷C5的反应 10 7 All SZGR 2.0 genes in this pathway
萨森对促性腺营养蛋白的反应 91 59 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
wakabayashi脂肪形成PPARG绑定8D 658 397 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-15/16/195/424/497 463 470 1A,m8 HSA-MIR-15Abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 cagcagcacacuguguuugu
miR-181 728 734 m8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
mir-324-3p 440 446 m8 hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
mir-330 458 464 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-34/449 573 580 1A,m8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B Aggcaguguauuguuagcuggc
mir-503 464 470 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
mir-96 131 137 m8 HSA-MIR-96brain UUUGGCACUAGCACAUUUUUGC