Gene Page:MAP2K2

Summary？
基因 5605
象征 MAP2K2
Synonyms cfc4 | mapkk2 | mek2 | mkk2 | prkmk2
Description 有丝分裂原激活的蛋白激酶激酶2
Reference MIM：601263|HGNC:HGNC:6842|Ensembl:ENSG00000126934|HPRD：03164|Vega：Otthumg00000134286
基因类型 蛋白质编码
Map location 19p13.3
Pascal p-value 0.794
Sherlock p-value 0.116
胎儿β -0.691
DMG 1 (# studies)
主持人 Frontal Cortex BA9
Support CANABINOID
多巴胺
METABOTROPIC GLUTAMATE RECEPTOR
5-羟色胺
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMANNRC
G2CDB.HUMANPSP
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 2
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0192

Section I. Genetics and epigenetics annotation

@差异甲基化基因

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG18156417 19 4099405 MAP2K2 8.5e-6 0.436 0.013 DMG：Wockner_2014
cg09563731 19 4090587 MAP2K2 2.916E-4 0.271 0.039 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0000166 nucleotide binding IEA -
去：0005515 蛋白质结合 IPI 11909642
去：0005524 ATP binding nas -
去：0004674 protein serine/threonine kinase activity nas -
GO:0004713 蛋白酪氨酸激酶活性 IEA -
GO：0016740 转移酶活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006468 protein amino acid phosphorylation nas -
去：0007265 RAS蛋白信号转导 经验 11520933
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 nas 8388392

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg mapk信号通路 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
Kegg Toll像受体信号通路 102 88 All SZGR 2.0 genes in this pathway
kegg天然杀伤细胞介导的细胞毒性 137 92 All SZGR 2.0 genes in this pathway
kegg t细胞受体信号通路 108 89 All SZGR 2.0 genes in this pathway
KEGG B细胞受体信号通路 75 56 All SZGR 2.0 genes in this pathway
kegg fc epsilon ri信号传导途径 79 58 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径 126 103 All SZGR 2.0 genes in this pathway
KEGG长期抑郁症 70 53 All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
kegg gnRH信号通路 101 77 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
Kegg Prion疾病 35 28 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG肾细胞癌 70 60 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤 65 56 All SZGR 2.0 genes in this pathway
KEGG前列腺癌 89 75 All SZGR 2.0 genes in this pathway
KEGG甲状腺癌 29 26 All SZGR 2.0 genes in this pathway
Kegg黑色素瘤 71 57 All SZGR 2.0 genes in this pathway
Kegg膀胱癌 42 33 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
Kegg急性髓样白血病 60 47 All SZGR 2.0 genes in this pathway
KEGG非小细胞肺癌 54 47 All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 36 28 All SZGR 2.0 genes in this pathway
生物卡丁生物肽途径 45 35 All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 39 29 All SZGR 2.0 genes in this pathway
Biocarta HCMV途径 17 16 All SZGR 2.0 genes in this pathway
Biocarta整联蛋白途径 38 29 All SZGR 2.0 genes in this pathway
Biocarta Pyk2途径 31 24 All SZGR 2.0 genes in this pathway
Biocarta MAPK途径 87 68 All SZGR 2.0 genes in this pathway
Biocarta CDK5途径 11 11 All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
Biocarta Barr MAPK途径 12 11 All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY 15 14 All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 37 30 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK途径 32 25 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR 17 15 All SZGR 2.0 genes in this pathway
PID FCER1途径 62 43 All SZGR 2.0 genes in this pathway
PID内皮素路径 63 52 All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 37 31 All SZGR 2.0 genes in this pathway
PID遇到了路径 80 60 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID Netrin途径 32 27 All SZGR 2.0 genes in this pathway
PID MTOR 4 Pathway 69 55 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID神经酰胺途径 48 37 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3途径 44 35 All SZGR 2.0 genes in this pathway
PID PDGFRB途径 129 103 All SZGR 2.0 genes in this pathway
pid ar nongenomic途径 31 27 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
PID套件途径 52 40 All SZGR 2.0 genes in this pathway
PID VEGFR1 2途径 69 57 All SZGR 2.0 genes in this pathway
PID炭疽路径 17 15 All SZGR 2.0 genes in this pathway
PID CD8 TCR下游途径 65 56 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome GRB2事件 22 20 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome SHC1事件 20 17 All SZGR 2.0 genes in this pathway
Reactome胰岛素受体信号传导级联 87 64 All SZGR 2.0 genes in this pathway
Reactome Arms介导的激活 17 17 All SZGR 2.0 genes in this pathway
Reactome长时间ERK激活事件 19 18 All SZGR 2.0 genes in this pathway
Reactome对RAS的信号传导 27 23 All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出 137 105 All SZGR 2.0 genes in this pathway
向ERK的Reactome信号传导 36 30 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
Reactome胃胃CREB信号传导途径通过PKC和MAPK 205 136 All SZGR 2.0 genes in this pathway
egfr信号中的Reactome SHC1事件 15 13 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
Reactome下游信号转导 95 76 All SZGR 2.0 genes in this pathway
Reactome Axon指导 251 188 All SZGR 2.0 genes in this pathway
Reactome NCAM信号传导，用于神经突的生长 64 49 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活 50 37 All SZGR 2.0 genes in this pathway
Reactome L1CAM相互作用 86 62 All SZGR 2.0 genes in this pathway
ILS的Reactome信号传导 107 86 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 34 25 All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导 77 57 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
Reactome IL 2信号传导 41 34 All SZGR 2.0 genes in this pathway
胰岛素受体的反应组信号传导 108 72 All SZGR 2.0 genes in this pathway
Reactome SOS介导的信号传导 14 13 All SZGR 2.0 genes in this pathway
Reactome RAF MAP激酶级联 10 10 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING 15 12 All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起 83 63 All SZGR 2.0 genes in this pathway
Reactome先天免疫系统 279 178 All SZGR 2.0 genes in this pathway
Reactome激活的TLR4信号传导 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome收费受体级联 118 84 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS 17 13 All SZGR 2.0 genes in this pathway
Gary CD5目标 473 314 All SZGR 2.0 genes in this pathway
Pramoonjago Sox4靶向DN 51 35 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
Tien肠益生菌24小时DN 214 133 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲 479 299 All SZGR 2.0 genes in this pathway
里克曼转移DN 261 155 All SZGR 2.0 genes in this pathway
康（Kang）由tert dn永生 102 67 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 3 DN 13 9 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 96 71 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
Cheng由雌二醇印记 110 68 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES 31 26 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 47 38 All SZGR 2.0 genes in this pathway
Yamashita肝癌干细胞DN 76 51 All SZGR 2.0 genes in this pathway
dasu IL6信号向上 59 44 All SZGR 2.0 genes in this pathway
Li DCP2绑定mRNA 89 57 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP 17 12 All SZGR 2.0 genes in this pathway