Gene Page:MAP2K5

Summary?
GeneID 5607
Symbol MAP2K5
Synonyms HsT17454|MAPKK5|MEK5|PRKMK5
Description mitogen-activated protein kinase kinase 5
Reference MIM:602520|HGNC:HGNC:6845|Ensembl:ENSG00000137764|HPRD:03951|Vega:OTTHUMG00000133264
Gene type protein-coding
Map location 15q23
Pascal p-value 0.038
Sherlock p-value 0.555
eGene Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DCXR 0.48 0.43
NQO1 0.45 0.42
C16orf14 0.45 0.36
C8orf56 0.45 0.34
ENHO 0.44 0.37
RHOC 0.44 0.41
POLD4 0.43 0.37
S100A6 0.43 0.37
TIMP4 0.43 0.34
UPP1 0.43 0.40
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF131 -0.34 -0.34
NELL2 -0.34 -0.36
PHF20L1 -0.34 -0.35
C1orf96 -0.33 -0.35
ALKBH8 -0.33 -0.34
VPRBP -0.33 -0.34
ZMYM2 -0.33 -0.34
USP7 -0.33 -0.32
CSGALNACT2 -0.33 -0.33
PUM2 -0.33 -0.34

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 23 16 All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 34 31 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 137 94 All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN 62 35 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN 60 39 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165 107 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP 60 45 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 95 58 All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 27 18 All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 48HR 9 6 All SZGR 2.0 genes in this pathway
SCHRAMM INHBA TARGETS DN 24 12 All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD DN 36 27 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN 80 49 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS RESPONSE 35 28 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 71 48 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN 45 31 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 67 48 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
TIAN BHLHA15 TARGETS 16 8 All SZGR 2.0 genes in this pathway