基因页：prPSAP2
Summary？
| 基因 | 5636 |
| 象征 | prPSAP2 |
| 同义词 | pAP41 |
| 描述 | 磷酸酚基磷酸合成酶相关蛋白2 |
| Reference | MIM：603762|HGNC：HGNC：9467|ENSEMBL：ENSG00000141127|HPRD：04789|Vega：Otthumg00000059406 |
| 基因类型 | 蛋白质编码 |
| 地图位置 | 17P11.2-P12 |
| Pascal P值 | 0.002 |
| Sherlock p-value | 0.845 |
| 胎儿β | 1.973 |
| DMG | 1(# studies) |
| 主持人 | 小脑半球 小脑 皮质 Frontal Cortex BA9 海马 硬膜基底神经节 元 |
基因in Data Sources
| 基因集名称 | 基因组方法 | 描述 | 信息 |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| 简历：Phewas | phenome-wide association studies (PheWAS) | 157个与精神分裂症相关的SNP | 1 |
| DMG：JAFFE_2016 | 全基因组DNA甲基化分析 | 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 | 1 |
Section I. Genetics and epigenetics annotation
简历：Phewas
简历：Phewas| SNP ID | 染色体 | 位置 | 等位基因 | p | 功能 | 基因 | 向上/向下距离 |
|---|---|---|---|---|---|---|---|
| RS4924935 | 17 | 18753870 | 无效的 | 1.506 | prPSAP2 | 无效的 |
差异甲基化基因
| 探测 | 染色体 | 位置 | 最近的基因 | p（dis） | beta（dis） | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG04747863 | 17 | 18761731 | prPSAP2 | 7.39e-9 | -0.012 | 3.67E-6 | DMG：JAFFE_2016 |
EQTL注释
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS7207570 | 17 | 18723995 | prPSAP2 | ENSG00000141127.10 | 3.66E-6 | 0 | -19403 | gtex_brain_putamen_basal |
| RS58407466 | 17 | 18725266 | prPSAP2 | ENSG00000141127.10 | 4.12E-6 | 0 | -18132 | gtex_brain_putamen_basal |
| RS28667787 | 17 | 18725527 | prPSAP2 | ENSG00000141127.10 | 1.677E-6 | 0 | -17871 | gtex_brain_putamen_basal |
| RS138491805 | 17 | 18728325 | prPSAP2 | ENSG00000141127.10 | 8.024e-7 | 0 | -15073 | gtex_brain_putamen_basal |
| RS35783872 | 17 | 18748820 | prPSAP2 | ENSG00000141127.10 | 2.969E-7 | 0 | 5422 | gtex_brain_putamen_basal |
| rs7214585 | 17 | 18755300 | prPSAP2 | ENSG00000141127.10 | 1.68E-6 | 0 | 11902 | gtex_brain_putamen_basal |
| RS4924936 | 17 | 18757213 | prPSAP2 | ENSG00000141127.10 | 9.429e-7 | 0 | 13815 | gtex_brain_putamen_basal |
| RS7222187 | 17 | 18760826 | prPSAP2 | ENSG00000141127.10 | 4.109E-7 | 0 | 17428 | gtex_brain_putamen_basal |
| RS8066636 | 17 | 18761109 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 17711 | gtex_brain_putamen_basal |
| RS59633160 | 17 | 18761396 | prPSAP2 | ENSG00000141127.10 | 1.418E-7 | 0 | 17998 | gtex_brain_putamen_basal |
| rs11548434 | 17 | 18761508 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 18110 | gtex_brain_putamen_basal |
| RS28374894 | 17 | 18761659 | prPSAP2 | ENSG00000141127.10 | 1.038E-7 | 0 | 18261 | gtex_brain_putamen_basal |
| RS28540773 | 17 | 18761754 | prPSAP2 | ENSG00000141127.10 | 7.787E-8 | 0 | 18356 | gtex_brain_putamen_basal |
| RS8068683 | 17 | 18761827 | prPSAP2 | ENSG00000141127.10 | 1.864E-7 | 0 | 18429 | gtex_brain_putamen_basal |
| RS397830161 | 17 | 18762169 | prPSAP2 | ENSG00000141127.10 | 2.291E-6 | 0 | 18771 | gtex_brain_putamen_basal |
| RS8077111 | 17 | 18763260 | prPSAP2 | ENSG00000141127.10 | 8.72E-7 | 0 | 19862 | gtex_brain_putamen_basal |
| RS1037037 | 17 | 18765021 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 21623 | gtex_brain_putamen_basal |
| RS8069826 | 17 | 18765490 | prPSAP2 | ENSG00000141127.10 | 8.534e-7 | 0 | 22092 | gtex_brain_putamen_basal |
| RS57766245 | 17 | 18765779 | prPSAP2 | ENSG00000141127.10 | 1.112E-7 | 0 | 22381 | gtex_brain_putamen_basal |
| RS72842306 | 17 | 18766115 | prPSAP2 | ENSG00000141127.10 | 2.587E-7 | 0 | 22717 | gtex_brain_putamen_basal |
| RS9915343 | 17 | 18766494 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 23096 | gtex_brain_putamen_basal |
| RS12942794 | 17 | 18767217 | prPSAP2 | ENSG00000141127.10 | 8.092E-8 | 0 | 23819 | gtex_brain_putamen_basal |
| RS7503663 | 17 | 18767446 | prPSAP2 | ENSG00000141127.10 | 1.226E-7 | 0 | 24048 | gtex_brain_putamen_basal |
| RS12600851 | 17 | 18767518 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 24120 | gtex_brain_putamen_basal |
| rs3764443 | 17 | 18767756 | prPSAP2 | ENSG00000141127.10 | 6.347E-7 | 0 | 24358 | gtex_brain_putamen_basal |
| rs3764445 | 17 | 18767923 | prPSAP2 | ENSG00000141127.10 | 8.2e-8 | 0 | 24525 | gtex_brain_putamen_basal |
| rs3764447 | 17 | 18768372 | prPSAP2 | ENSG00000141127.10 | 7.926E-8 | 0 | 24974 | gtex_brain_putamen_basal |
| rs3764448 | 17 | 18768437 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 25039 | gtex_brain_putamen_basal |
| rs9903574 | 17 | 18768582 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 25184 | gtex_brain_putamen_basal |
| RS2386404 | 17 | 18769349 | prPSAP2 | ENSG00000141127.10 | 8.534e-7 | 0 | 25951 | gtex_brain_putamen_basal |
| RS2386403 | 17 | 18769600 | prPSAP2 | ENSG00000141127.10 | 1.681E-6 | 0 | 26202 | gtex_brain_putamen_basal |
| RS6502672 | 17 | 18769750 | prPSAP2 | ENSG00000141127.10 | 9.16e-7 | 0 | 26352 | gtex_brain_putamen_basal |
| RS11868500 | 17 | 18770254 | prPSAP2 | ENSG00000141127.10 | 8.534e-7 | 0 | 26856 | gtex_brain_putamen_basal |
| rs12937933 | 17 | 18770283 | prPSAP2 | ENSG00000141127.10 | 7.18e-8 | 0 | 26885 | gtex_brain_putamen_basal |
| RS11868520 | 17 | 18770367 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 26969 | gtex_brain_putamen_basal |
| RS2305064 | 17 | 18770733 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 27335 | gtex_brain_putamen_basal |
| RS9912713 | 17 | 18771145 | prPSAP2 | ENSG00000141127.10 | 1.068E-6 | 0 | 27747 | gtex_brain_putamen_basal |
| rs2166182 | 17 | 18772059 | prPSAP2 | ENSG00000141127.10 | 7.523E-7 | 0 | 28661 | gtex_brain_putamen_basal |
| RS4290526 | 17 | 18772967 | prPSAP2 | ENSG00000141127.10 | 2.668E-7 | 0 | 29569 | gtex_brain_putamen_basal |
| rs34417974 | 17 | 18773636 | prPSAP2 | ENSG00000141127.10 | 9.392E-8 | 0 | 30238 | gtex_brain_putamen_basal |
| RS9797255 | 17 | 18774097 | prPSAP2 | ENSG00000141127.10 | 8.231E-8 | 0 | 30699 | gtex_brain_putamen_basal |
| RS7212905 | 17 | 18774271 | prPSAP2 | ENSG00000141127.10 | 8.088e-8 | 0 | 30873 | gtex_brain_putamen_basal |
| RS7214754 | 17 | 18774603 | prPSAP2 | ENSG00000141127.10 | 8.082e-8 | 0 | 31205 | gtex_brain_putamen_basal |
| RS6502673 | 17 | 18775322 | prPSAP2 | ENSG00000141127.10 | 1.035E-7 | 0 | 31924 | gtex_brain_putamen_basal |
| RS4393623 | 17 | 18775900 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 32502 | gtex_brain_putamen_basal |
| RS7503678 | 17 | 18776020 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 32622 | gtex_brain_putamen_basal |
| rs10852854 | 17 | 18776390 | prPSAP2 | ENSG00000141127.10 | 9.606E-8 | 0 | 32992 | gtex_brain_putamen_basal |
| RS146888042 | 17 | 18776572 | prPSAP2 | ENSG00000141127.10 | 9.792E-8 | 0 | 33174 | gtex_brain_putamen_basal |
| RS12451220 | 17 | 18778421 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 35023 | gtex_brain_putamen_basal |
| RS12451200 | 17 | 18778493 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 35095 | gtex_brain_putamen_basal |
| RS7220661 | 17 | 18779130 | prPSAP2 | ENSG00000141127.10 | 6.697E-8 | 0 | 35732 | gtex_brain_putamen_basal |
| rs12452289 | 17 | 18781809 | prPSAP2 | ENSG00000141127.10 | 7.854 e-8 | 0 | 38411 | gtex_brain_putamen_basal |
| RS12449821 | 17 | 18781948 | prPSAP2 | ENSG00000141127.10 | 1.657E-7 | 0 | 38550 | gtex_brain_putamen_basal |
| RS35911764 | 17 | 18782582 | prPSAP2 | ENSG00000141127.10 | 7.854 e-8 | 0 | 39184 | gtex_brain_putamen_basal |
| rs112429999 | 17 | 18782865 | prPSAP2 | ENSG00000141127.10 | 8.198E-8 | 0 | 39467 | gtex_brain_putamen_basal |
| RS79897963 | 17 | 18783047 | prPSAP2 | ENSG00000141127.10 | 1.19e-7 | 0 | 39649 | gtex_brain_putamen_basal |
| rs75520042 | 17 | 18783052 | prPSAP2 | ENSG00000141127.10 | 2.213E-7 | 0 | 39654 | gtex_brain_putamen_basal |
| RS72834996 | 17 | 18783059 | prPSAP2 | ENSG00000141127.10 | 7.515E-8 | 0 | 39661 | gtex_brain_putamen_basal |
| rs11650163 | 17 | 18784404 | prPSAP2 | ENSG00000141127.10 | 1.407E-6 | 0 | 41006 | gtex_brain_putamen_basal |
| RS68046274 | 17 | 18785126 | prPSAP2 | ENSG00000141127.10 | 7.864e-8 | 0 | 41728 | gtex_brain_putamen_basal |
| RS2892016 | 17 | 18786776 | prPSAP2 | ENSG00000141127.10 | 8.883e-8 | 0 | 43378 | gtex_brain_putamen_basal |
| RS2892015 | 17 | 18786849 | prPSAP2 | ENSG00000141127.10 | 7.864e-8 | 0 | 43451 | gtex_brain_putamen_basal |
| RS4334348 | 17 | 18787004 | prPSAP2 | ENSG00000141127.10 | 7.864e-8 | 0 | 43606 | gtex_brain_putamen_basal |
| RS4319824 | 17 | 18787418 | prPSAP2 | ENSG00000141127.10 | 7.907E-8 | 0 | 44020 | gtex_brain_putamen_basal |
| RS9914914 | 17 | 18787780 | prPSAP2 | ENSG00000141127.10 | 7.864e-8 | 0 | 44382 | gtex_brain_putamen_basal |
| RS7222748 | 17 | 18787976 | prPSAP2 | ENSG00000141127.10 | 7.864e-8 | 0 | 44578 | gtex_brain_putamen_basal |
| RS4924938 | 17 | 18788559 | prPSAP2 | ENSG00000141127.10 | 7.866e-8 | 0 | 45161 | gtex_brain_putamen_basal |
| rs12600722 | 17 | 18788987 | prPSAP2 | ENSG00000141127.10 | 1.724E-7 | 0 | 45589 | gtex_brain_putamen_basal |
| RS9748173 | 17 | 18789671 | prPSAP2 | ENSG00000141127.10 | 1.321E-7 | 0 | 46273 | gtex_brain_putamen_basal |
| RS9748183 | 17 | 18789724 | prPSAP2 | ENSG00000141127.10 | 7.719E-8 | 0 | 46326 | gtex_brain_putamen_basal |
| RS8071147 | 17 | 18790678 | prPSAP2 | ENSG00000141127.10 | 8.541E-8 | 0 | 47280 | gtex_brain_putamen_basal |
| rs8071458 | 17 | 18790840 | prPSAP2 | ENSG00000141127.10 | 7.866e-8 | 0 | 47442 | gtex_brain_putamen_basal |
| RS9912568 | 17 | 18792719 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 49321 | gtex_brain_putamen_basal |
| rs3803835 | 17 | 18793061 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 49663 | gtex_brain_putamen_basal |
| RS3826380 | 17 | 18793225 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 49827 | gtex_brain_putamen_basal |
| RS11650153 | 17 | 18793573 | prPSAP2 | ENSG00000141127.10 | 4.372E-8 | 0 | 50175 | gtex_brain_putamen_basal |
| RS9898426 | 17 | 18794071 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 50673 | gtex_brain_putamen_basal |
| RS71862188 | 17 | 18794107 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 50709 | gtex_brain_putamen_basal |
| RS4924774 | 17 | 18794920 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 51522 | gtex_brain_putamen_basal |
| RS9906799 | 17 | 18795317 | prPSAP2 | ENSG00000141127.10 | 7.869e-8 | 0 | 51919 | gtex_brain_putamen_basal |
| RS8078993 | 17 | 18797126 | prPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 53728 | gtex_brain_putamen_basal |
| RS57035178 | 17 | 18797767 | prPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 54369 | gtex_brain_putamen_basal |
| RS4322727 | 17 | 18798573 | prPSAP2 | ENSG00000141127.10 | 2.692E-6 | 0 | 55175 | gtex_brain_putamen_basal |
| RS7209853 | 17 | 18798600 | prPSAP2 | ENSG00000141127.10 | 7.909E-8 | 0 | 55202 | gtex_brain_putamen_basal |
| RS4510081 | 17 | 18798846 | prPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 55448 | gtex_brain_putamen_basal |
| RS4924940 | 17 | 18800092 | prPSAP2 | ENSG00000141127.10 | 8.683E-8 | 0 | 56694 | gtex_brain_putamen_basal |
| RS8074020 | 17 | 18801380 | prPSAP2 | ENSG00000141127.10 | 8.393E-7 | 0 | 57982 | gtex_brain_putamen_basal |
| rs8073436 | 17 | 18801841 | prPSAP2 | ENSG00000141127.10 | 7.878E-8 | 0 | 58443 | gtex_brain_putamen_basal |
| RS6502676 | 17 | 18803459 | prPSAP2 | ENSG00000141127.10 | 9.488e-8 | 0 | 60061 | gtex_brain_putamen_basal |
| RS11078422 | 17 | 18804413 | prPSAP2 | ENSG00000141127.10 | 2.17E-7 | 0 | 61015 | gtex_brain_putamen_basal |
| rs7223173 | 17 | 18805887 | prPSAP2 | ENSG00000141127.10 | 4.882e-7 | 0 | 62489 | gtex_brain_putamen_basal |
| RS4924943 | 17 | 18806025 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 62627 | gtex_brain_putamen_basal |
| RS8067882 | 17 | 18807131 | prPSAP2 | ENSG00000141127.10 | 8.071E-8 | 0 | 63733 | gtex_brain_putamen_basal |
| RS8072860 | 17 | 18807884 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 64486 | gtex_brain_putamen_basal |
| RS8071783 | 17 | 18807939 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 64541 | gtex_brain_putamen_basal |
| RS8077775 | 17 | 18809543 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 66145 | gtex_brain_putamen_basal |
| RS4924944 | 17 | 18810002 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 66604 | gtex_brain_putamen_basal |
| RS7222893 | 17 | 18811702 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 68304 | gtex_brain_putamen_basal |
| RS35137608 | 17 | 18812102 | prPSAP2 | ENSG00000141127.10 | 8.055e-8 | 0 | 68704 | gtex_brain_putamen_basal |
| RS4924945 | 17 | 18813160 | prPSAP2 | ENSG00000141127.10 | 8.521E-7 | 0 | 69762 | gtex_brain_putamen_basal |
| RS9906795 | 17 | 18816740 | prPSAP2 | ENSG00000141127.10 | 2.555e-6 | 0 | 73342 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| 通过CD40 UP的Hollmann凋亡 | 201 | 125 | All SZGR 2.0 genes in this pathway |
| Chemnitz对前列腺素E2 DN的反应 | 391 | 222 | All SZGR 2.0 genes in this pathway |
| 迪亚兹慢性巨态性白血病 | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA UP | 305 | 185 | All SZGR 2.0 genes in this pathway |
| 奥斯曼膀胱癌DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| Schlosser血清反应DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC网络 | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| Pujana ATM PCC网络 | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC网络 | 779 | 480 | All SZGR 2.0 genes in this pathway |
| 弗莱赫纳活检肾脏移植被拒绝vs ok dn | 546 | 351 | All SZGR 2.0 genes in this pathway |
| Stearman肺癌早期与晚期 | 125 | 89 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| YAO对孕酮簇的时间反应13 | 172 | 107 | All SZGR 2.0 genes in this pathway |
| Verhaak胶质母细胞瘤神经 | 129 | 85 | All SZGR 2.0 genes in this pathway |