Gene Page:CHST7

概括?
基因 56548
Symbol CHST7
Synonyms C6ST-2|GST-5
Description carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
Reference MIM:300375|HGNC:HGNC:13817|Ensembl:ENSG00000147119|HPRD:02302|Vega:OTTHUMG00000021423
Gene type protein-coding
Map location Xp11.23
Sherlock p-value 0.89
Fetal beta -0.36
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs760697 chrX 46447343 CHST7 56548 6.093E-6 cis
rs5905551 chrX 46461535 CHST7 56548 1.478E-4 cis
rs5952927 chrX 46562924 CHST7 56548 0.2 cis
rs6980720 chr8 127075270 CHST7 56548 0.17 trans
rs11015223 chr10 26971331 CHST7 56548 0.14 trans
rs760697 chrX 46447343 CHST7 56548 9.985E-4 trans
rs5905551 chrX 46461535 CHST7 56548 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ACD 0.92 0.92
TOR2A 0.92 0.90
LMBR1L 0.92 0.92
PRR14 0.91 0.88
MIIP 0.90 0.91
FAM127B 0.90 0.89
PTOV1 0.90 0.90
NARF 0.90 0.89
PCIF1 0.90 0.85
C17orf62 0.89 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.69 -0.82
AF347015.31 -0.67 -0.78
MT-CO2 -0.67 -0.78
AF347015.8 -0.67 -0.81
MT-CYB -0.66 -0.80
AF347015.33 -0.66 -0.79
AF347015.15 -0.65 -0.80
ABCG2 -0.64 -0.70
AIFM3 -0.64 -0.69
AF347015.2 -0.63 -0.80

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IDA 10913333
GO:0016740 transferase activity IEA -
GO:0008459 chondroitin 6-sulfotransferase activity IDA 10781596
GO:0034482 chondroitin 2-O-sulfotransferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006044 N-acetylglucosamine metabolic process IDA 10913333
GO:0005976 polysaccharide metabolic process TAS 10781596
GO:0006790 sulfur metabolic process IDA 10913333
GO:0030206 chondroitin sulfate biosynthetic process IDA 10781596
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0005794 Golgi apparatus IEA -
去：0016020 membrane IEA -
GO：0016021 integral to membrane NAS 10913333
GO：0016021 integral to membrane TAS 10781596

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS CHONDROITIN SULFATE 22 16 All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE BIOSYNTHESIS 21 15 All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 33 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 77 46 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165 104 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 81 52 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP 89 62 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 115 73 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-203.1 312 318 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-23 395 402 1A,m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 395 401 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-328 405 412 1A,m8 hsa-miR-328brain CUGGCCCUCUCUGCCCUUCCGU