SZGR2 - Beplay体育中心

Summary？

基因	5664
象征	PSEN2
Synonyms	AD3L \| AD4 \| CMD1V \| PS2 \| STM2
Description	Presenilin 2
Reference	MIM：600759\|HGNC：HGNC：9509\|ENSEMBL：ENSG00000143801\|HPRD:02860\|Vega:OTTHUMG00000037563
基因类型	蛋白质编码
Map location	1q42.13
Sherlock p-value	0.72
胎儿β	-1.21
主持人	元
Support	神经营养蛋白信号传导

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0687

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
ifi35	0.95	0.94
mt1e	0.91	0.90
RTP4	0.90	0.84
PSMB9	0.90	0.93
B2M	0.89	0.90
ifitm1	0.89	0.88
TAP1	0.87	0.83
RARRES3	0.87	0.92
OAS1	0.87	0.83
OASL	0.87	0.83

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
Ankrd17	-0.68	-0.79
MCM3AP	-0.68	-0.81
eif4enif1	-0.68	-0.79
MYO18A	-0.68	-0.72
SFRS14	-0.68	-0.81
heatr5b	-0.68	-0.82
USP7	-0.68	-0.77
CKAP5	-0.68	-0.82
PDXDC1	-0.67	-0.78
SPTAN1	-0.67	-0.80

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005515	蛋白质结合	IPI		12297508
去：0008233	肽酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO：0042987	淀粉样前体蛋白分解代谢过程	TAS		15274632
去：0006509	膜蛋白外域蛋白蛋白蛋白水解	IDA		15274632
去：0007220	Notch receptor processing	TAS		15274632
去：0008632	凋亡程序	TAS		8939861
GO:0007059	染色体分离	TAS		9298903
GO：0016485	protein processing	IDA		15274632
GO:0043085	positive regulation of catalytic activity	IDA		15274632
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0000139	Golgi membrane	IEA		-
GO:0000776	kinetochore	TAS		9298903
去：0005794	高尔基体	IDA		15274632
去：0005789	内质网膜	IEA		-
去：0005639	核内膜的积分	TAS		9298903
去：0005783	内质网	IDA		15274632
去：0016020	membrane	IEA		-
去：0005887	integral to plasma membrane	IDA		15274632

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
APBA1	D9S411E \|mint1 \|x11 \|x11a \|x11alpha	淀粉样β（A4）前体蛋白-binding, family A, member 1	亲和力捕获 - 韦斯特恩	Biogrid	12196555
APBA2	D15S1518E \|HST16821 \|lin-10 \|MGC99508 \|MGC：14091 \|mint2 \|x11l	淀粉样β（A4）前体蛋白-binding, family A, member 2	亲和力捕获 - 韦斯特恩	Biogrid	12196555
APBA3	MGC：15815 \|x11l2 \|mint3	淀粉样β（A4）前体蛋白-binding, family A, member 3	亲和力捕获 - 韦斯特恩	Biogrid	12196555
aph1a	6530402N02RIK \|Aph-1a \|CGI-78	anterior pharynx defective 1 homolog A (C. elegans)	-	HPRD,BioGRID	12297508\|12471034
aph1b	Aph-1b \|DKFZP564D0372 \|Pro1328 \|PSFL \|TAAV688	前咽部有缺陷1同源物B（秀丽隐杆线虫）	-	HPRD	12297508
应用程序	AAA \|Abeta \|abpp \|AD1 \|appi \|ctfgamma \|CVAP \|PN2	淀粉样β（A4）前体蛋白	PS2与应用程序交互。	绑定	9223340
Bcl2l1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	Bcl2样1	-	HPRD,BioGRID	10446169
CAPN1	CANP \| CANP1 \| CANPL1 \| muCANP \| muCL	钙蛋白酶1，（mu/i）大亚基	-	HPRD,BioGRID	9852298
CIB1	cib \|kip \|Kip1 \|SIP2-28	钙和整联蛋白结合1（Calmyrin）	-	HPRD,BioGRID	10366599
ctnnd2	GT24 \| NPRAP	Catenin（钙粘蛋白相关蛋白），三角洲2（神经plakophilin相关的手臂重复蛋白）	-	HPRD	10037471
DOCK3	KIAA0299 \|Moca \|PBP	细胞因子3	-	HPRD	10854253
FHL2	AAG11 \|Dral \|Slim3	四个半域2	-	HPRD,BioGRID	11001931
flnb	ABP-278 \|aoi \|DKFZP686A1668 \|DKFZP686O033 \|FH1 \|fln1l \|LRS1 \|sct \|TABP \|轻敲	Filamin B，β（肌动蛋白结合蛋白278）	-	HPRD,BioGRID	9437013
GFAP	FLJ45472	胶质原纤维酸性蛋白	Two-hybrid	Biogrid	12058025
ICAM5	TLCN \|TLN	intercellular adhesion molecule 5, telencephalin	-	HPRD,BioGRID	11719200
kcnip3	CSEN \| DREAM \| KCHIP3 \| MGC18289	KV通道相互作用蛋白3，calsenilin	-	HPRD,BioGRID	9771752
KCNIP4	calp \|Kchip4 \|MGC44947	KV通道相互作用蛋白4	-	HPRD,BioGRID	11847232
mettl2b	FLJ11350 \| FLJ12760 \| METL \| METTL2 \| METTL2A \| PSENIP1	甲基转移酶像2B一样	-	HPRD,BioGRID	11738826
NCSTN	aph2 \|KIAA0253	nicastrin	-	HPRD,BioGRID	10993067
PSEN1	AD3 \| FAD \| PS1 \| S182	Presenilin 1	亲和力捕获 - 韦斯特恩	Biogrid	12471034
PSENEN	MDS033 \| MSTP064 \| PEN-2 \| PEN2	presenilin enhancer 2 homolog (C. elegans)	-	HPRD,BioGRID	12198112\|12639958
斯里	FLJ26259 \|SCN	sorcin	-	HPRD,BioGRID	10748169
UBQLN1	DA41 \|DSK2 \|FLJ90054 \|plic-1 \|XDRP1	ubiquilin 1	-	HPRD,BioGRID	11076969

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
Kegg Notch信号通路	47	35	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
Biocarta Hivnef途径	58	43	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4	38	30	All SZGR 2.0 genes in this pathway
Reactome激活的Notch1将信号传输到细胞核	27	18	All SZGR 2.0 genes in this pathway
Notch4的Reactome信号传导	12	10	All SZGR 2.0 genes in this pathway
Notch2的Reactome信号传导	12	10	All SZGR 2.0 genes in this pathway
Notch1的Reactome信号传导	70	46	All SZGR 2.0 genes in this pathway
Notch3的Reactome信号传导	12	10	All SZGR 2.0 genes in this pathway
Reactome调节的p75NTR蛋白水解	10	9	All SZGR 2.0 genes in this pathway
Reactome NRIF信号是细胞核的细胞死亡	15	10	All SZGR 2.0 genes in this pathway
Reactome细胞死亡信号通过Nrage NRIF和NADE传导	60	43	All SZGR 2.0 genes in this pathway
Reactome P75 NTR受体介导的信号传导	81	61	All SZGR 2.0 genes in this pathway
Notch的Reactome信号传导	103	64	All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP	59	38	All SZGR 2.0 genes in this pathway
Davicioni分子臂与ERMS	332	228	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
Hoebeke淋巴干细胞DN	86	59	All SZGR 2.0 genes in this pathway
Elvidge缺氧DN	146	94	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS UP	67	40	All SZGR 2.0 genes in this pathway
刘cdx2靶向	36	22	All SZGR 2.0 genes in this pathway
悍马皮肤癌进度DN	100	64	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN	203	134	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标	230	156	All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇2	30	23	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN	65	44	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP	78	56	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA DN	19	14	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
伯顿成生成6	189	112	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3	160	103	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN	366	257	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
Rutella对HGF的反应	418	282	All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4 DN的响应	245	150	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN	72	47	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-183	74	81	1A，M8	HSA-MIR-183	UAUGGCACUGGUAGAAUUCACUG
mir-30-5p	121	127	M8	HSA-MIR-30A-5P	uguaaaacauccuccugagaag
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:PSEN2