SZGR2 - Beplay体育中心

Summary？

基因	5682
象征	PSMA1
Synonyms	HC2 \| HEL-S-275 \| NU \| PROS30
Description	proteasome subunit alpha 1
Reference	MIM：602854\|HGNC：HGNC：9530\|Ensembl:ENSG00000129084\|HPRD:04170\|Vega:OTTHUMG00000165825
基因类型	蛋白质编码
Map location	11P15.1
Pascal p-value	0.627
Sherlock p-value	0.782
胎儿β	0.191
DMG	1(# studies)
主持人	元

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：JAFFE_2016	全基因组DNA甲基化分析	这个数据集包括2104探针/论文认定相关with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0044

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG01506871	11	14541756	PSMA1	7.54E-8	-0.006	1.79E-5	DMG：JAFFE_2016

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ASNA1	0.91	0.89
PRDX2	0.90	0.93
ARF5	0.90	0.88
COMMD9	0.90	0.88
C17orf81	0.89	0.88
CREB3	0.89	0.85
C19orf62	0.89	0.84
POP7	0.89	0.86
UQCRC1	0.89	0.86
MRPS18B	0.88	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.26	-0.67	-0.63
AF347015.8	-0.65	-0.59
AF347015.18	-0.64	-0.68
AF347015.2	-0.64	-0.57
AF347015.15	-0.63	-0.58
mt-cyb	-0.62	-0.58
MT-ATP8	-0.62	-0.62
AF347015.27	-0.60	-0.58
AF347015.33	-0.60	-0.57
MT-CO2	-0.59	-0.52

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0003723	RNA结合	TAS		7681138
去：0005515	蛋白质结合	IPI		15225636
去：0004298	苏氨酸型内肽酶活性	IEA		-
GO:0008233	肽酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006511	ubiquitin-dependent protein catabolic process	IEA		-
GO:0031145	后期促进复合依赖性蛋白酶体依赖性蛋白质分解代谢过程	经验		11285280
GO：0051436	在有丝分裂细胞周期期间泛素 - 蛋白连接酶活性的负调控	经验		15029244
GO：0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	经验		12791267
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0005829	细胞质	IEA		-
GO:0005839	proteasome core complex	IEA		-
去：0005844	polysome	TAS		7681138
去：0005634	nucleus	TAS		7681138
去：0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
C11orf49	FLJ22210 \|MGC4707	chromosome 11 open reading frame 49	Two-hybrid	Biogrid	16169070
Calcoco2	MGC17318 \| NDP52	calcium binding and coiled-coil domain 2	Two-hybrid	Biogrid	16189514
CCDC85B	dipa	coiled-coil domain containing 85B	Two-hybrid	Biogrid	16189514
CCNH	cak \|p34 \|p37	细胞周期蛋白h	Two-hybrid	Biogrid	16189514
dleu1	BCMS \|DLB1 \|dleu2 \|leu1 \|Leu2 \|MGC22430 \|NCRNA00021 \|XTP6	deleted in lymphocytic leukemia 1 (non-protein coding)	Two-hybrid	Biogrid	16169070
KCTD17	FLJ12242 \| FLJ98761	含17的钾通道四聚化域	Two-hybrid	Biogrid	16189514
KRT15	CK15 \|K15 \|k1co	keratin 15	Two-hybrid	Biogrid	16189514
MCM6	MCG40308 \|MIS5 \|P105MCM	minichromosome maintenance complex component 6	Two-hybrid	Biogrid	16189514
NECAB2	EFCBP2	N末端EF手钙结合蛋白2	Two-hybrid	Biogrid	16189514
NMI	-	N-myc (and STAT) interactor	Two-hybrid	Biogrid	16189514
PLK1	PLK \| STPK13	polo样激酶1（果蝇）	亲和力捕获 - 韦斯特恩	Biogrid	11205743
PSMA2	HC3 \|Mu \|PMSA2 \|PSC2	proteasome (prosome, macropain) subunit, alpha type, 2	-	HPRD	10436176
PSMA3	HC8 \| MGC12306 \| MGC32631 \| PSC3	proteasome (prosome, macropain) subunit, alpha type, 3	-	HPRD,BioGRID	9451443
PSMD13	HSPC027 \|rpn9 \|S11 \|P40.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	Affinity Capture-MS	Biogrid	17353931
RAD54B	FSBP \|RDH54	RAD54 homolog B (S. cerevisiae)	Two-hybrid	Biogrid	16189514
TSC22D4	THG-1 \|THG1	TSC22 domain family, member 4	Two-hybrid	Biogrid	16189514
VIM	FLJ36605	波形蛋白	Two-hybrid	Biogrid	16189514

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg蛋白酶体	48	28	All SZGR 2.0 genes in this pathway
BIOCARTA PROTEASOME PATHWAY	28	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT	65	41	All SZGR 2.0 genes in this pathway
可溶性外源抗原内体的反应组交叉表现	48	29	All SZGR 2.0 genes in this pathway
Reactome抗原加工交叉呈现	76	48	All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY	61	40	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
Reactome ORC1从染色质中去除	67	37	All SZGR 2.0 genes in this pathway
B细胞受体BCR的Reactome下游信号传导事件	97	66	All SZGR 2.0 genes in this pathway
B细胞中NF Kappab的反应组激活	64	43	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	51	31	All SZGR 2.0 genes in this pathway
反应组CDK介导的磷酸化和CDC6的去除	48	27	All SZGR 2.0 genes in this pathway
氨基酸和衍生物的反应组代谢	200	136	All SZGR 2.0 genes in this pathway
鸟氨酸脱羧酶ODC的反应组调节	49	33	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS	58	34	All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC	325	185	All SZGR 2.0 genes in this pathway
Reactome细胞周期检查点	124	70	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	65	40	All SZGR 2.0 genes in this pathway
Reactome P53依赖G1 DNA损伤响应	57	35	All SZGR 2.0 genes in this pathway
Reactome M G1过渡	81	45	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	56	31	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	51	30	All SZGR 2.0 genes in this pathway
mRNA的反应组代谢	284	128	All SZGR 2.0 genes in this pathway
READEM RNA的代谢	330	155	All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相	137	79	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE	85	46	All SZGR 2.0 genes in this pathway
Reactome有丝分裂M M G1相	172	98	All SZGR 2.0 genes in this pathway
复制前复合物的反应组装	65	36	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
AUF1 HNRNP D0对mRNA的反应组不稳定	53	31	All SZGR 2.0 genes in this pathway
Reactome DNA复制	192	110	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
Reactome HIV感染	207	122	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
Reactome APC C CDH1介导的CDC20和其他APC C CDH1靶向蛋白质的降解早期G1早期	72	38	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	73	40	All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	64	34	All SZGR 2.0 genes in this pathway
Reactome SCF Beta TRCP介导的EMI1降解	51	32	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
Reactome I类MHC介导的抗原加工表现	251	156	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	212	129	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
Reactome SCFSKP2介导的P27 P21降解	56	34	All SZGR 2.0 genes in this pathway
Reactome VIF介导的apobec3g降解	52	30	All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央	285	181	All SZGR 2.0 genes in this pathway
Casorelli急性临时细胞白血病	177	110	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇1 DN	378	231	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP	380	213	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络	779	480	All SZGR 2.0 genes in this pathway
洛佩兹MBD目标	957	597	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN	309	206	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
伯顿成生成5	126	78	All SZGR 2.0 genes in this pathway
肺癌和成纤维细胞的钟分泌组	132	93	All SZGR 2.0 genes in this pathway
抗原演示中的pellicciotta HDAC DN	49	38	All SZGR 2.0 genes in this pathway
Hillion HMGA1目标	90	71	All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标	92	68	All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定	491	310	All SZGR 2.0 genes in this pathway
Zheng Foxp3目标胸腺	196	137	All SZGR 2.0 genes in this pathway
黄蛋白酶体基因模块	49	35	All SZGR 2.0 genes in this pathway
级结肠癌	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN	366	257	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Bakker FOXO3靶向DN	187	109	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
CTBP1和SATB1的Purbey目标	87	52	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-128	285	291	1A	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	285	291	1A	hsa-miR-128b	ucacagugaaccggucuuc
miR-27	285	292	1A，M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	285	292	1A，M8	HSA-MIR-27B^brain	UUCACAGUGGCUAAGUUCUGC
miR-494	300	306	1A	HSA-MIR-494^brain	ugaaacauacgggaaaccucuu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:PSMA1