Gene Page:PSMA2

Summary?
GeneID 5683
Symbol PSMA2
Synonyms HC3|MU|PMSA2|PSC2
Description proteasome subunit alpha 2
Reference MIM:176842|HGNC:HGNC:9531|Ensembl:ENSG00000106588|HPRD:08907|Vega:OTTHUMG00000023916
Gene type protein-coding
Map location 7p13
Pascal p-value 0.034
Sherlock p-value 0.685

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Expression Meta-analysis of gene expression Pvalue: 1.991

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PUF60 0.93 0.94
RUVBL2 0.93 0.91
EIF6 0.92 0.91
PRMT1 0.92 0.94
SEC13 0.91 0.92
PPP4C 0.91 0.91
POLD2 0.91 0.90
C17orf49 0.90 0.91
TRIM39 0.90 0.89
NFKBIL1 0.90 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.70 -0.81
AF347015.33 -0.68 -0.78
AF347015.8 -0.68 -0.79
MT-CO2 -0.68 -0.77
MT-CYB -0.68 -0.79
AF347015.31 -0.67 -0.77
AF347015.15 -0.67 -0.80
AF347015.2 -0.64 -0.78
AF347015.26 -0.62 -0.77
AF347015.9 -0.61 -0.75

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 15225636|17353931
GO:0004298 threonine-type endopeptidase activity IEA -
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process EXP 11285280
GO:0051436 negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle EXP 15029244
GO:0051437 positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle EXP 12791267
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol IEA -
GO:0005839 proteasome core complex IEA -
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARHGDIG RHOGDI-3 Rho GDP dissociation inhibitor (GDI) gamma - HPRD 10436176
HUS1 - HUS1 checkpoint homolog (S. pombe) Affinity Capture-MS BioGRID 17353931
KIF3C - kinesin family member 3C - HPRD 10436176
NME2 MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | puf non-metastatic cells 2, protein (NM23B) expressed in Affinity Capture-MS BioGRID 17353931
PLK1 PLK | STPK13 polo-like kinase 1 (Drosophila) Affinity Capture-MS BioGRID 11205743
PSMA1 HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30 proteasome (prosome, macropain) subunit, alpha type, 1 - HPRD 10436176
PSMA6 IOTA | MGC22756 | MGC2333 | MGC23846 | PROS27 | p27K proteasome (prosome, macropain) subunit, alpha type, 6 - HPRD 10436176
PSMA7 C6 | HSPC | MGC3755 | RC6-1 | XAPC7 proteasome (prosome, macropain) subunit, alpha type, 7 - HPRD 10436176
PSMB1 FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5 proteasome (prosome, macropain) subunit, beta type, 1 - HPRD 10436176
PSMB10 LMP10 | MECL1 | MGC1665 | beta2i proteasome (prosome, macropain) subunit, beta type, 10 - HPRD 10436176
PSMB2 HC7-I | MGC104215 | MGC126885 proteasome (prosome, macropain) subunit, beta type, 2 - HPRD 10436176
PSMB3 HC10-II | MGC4147 proteasome (prosome, macropain) subunit, beta type, 3 - HPRD 10436176
PSMB4 HN3 | HsN3 | PROS26 proteasome (prosome, macropain) subunit, beta type, 4 - HPRD 10436176
PSMB5 LMPX | MB1 | MGC104214 | X proteasome (prosome, macropain) subunit, beta type, 5 - HPRD 10436176
PSMB6 DELTA | LMPY | MGC5169 | Y proteasome (prosome, macropain) subunit, beta type, 6 - HPRD 10436176
PSMB7 Z proteasome (prosome, macropain) subunit, beta type, 7 - HPRD 10436176
PSMB8 D6S216 | D6S216E | LMP7 | MGC1491 | PSMB5i | RING10 | beta5i proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) - HPRD 10436176
PSMB9 LMP2 | MGC70470 | PSMB6i | RING12 | beta1i proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) - HPRD 10436176
PSMD6 KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PROTEASOME 48 28 All SZGR 2.0 genes in this pathway
BIOCARTA PROTEASOME PATHWAY 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 65 41 All SZGR 2.0 genes in this pathway
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 48 29 All SZGR 2.0 genes in this pathway
REACTOME P抗原ROCESSING CROSS PRESENTATION 76 48 All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 61 40 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN 67 37 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 97 66 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 64 43 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 51 31 All SZGR 2.0 genes in this pathway
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 48 27 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 49 33 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS 58 34 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 57 35 All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 81 45 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 56 31 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 51 30 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 85 46 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 36 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 53 31 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 72 38 All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 73 40 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 64 34 All SZGR 2.0 genes in this pathway
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 51 32 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
REACTOME P抗原ROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 56 34 All SZGR 2.0 genes in this pathway
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 52 30 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP 34 23 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 75 44 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 81 52 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR 55 38 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 93 65 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 49 38 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 77 52 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-132/212 150 156 1A hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG