Gene Page:OTUD7B

Summary?
GeneID 56957
Symbol OTUD7B
Synonyms CEZANNE|ZA20D1
Description OTU deubiquitinase 7B
Reference MIM:611748|HGNC:HGNC:16683|HPRD:10313|
Gene type protein-coding
Map location 1q21.2
Fetal beta -0.258

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs140505938 chr1 150031490 TC 9.337E-10 intergenic OTUD7B,VPS45 dist=48804;dist=7860


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0005515 protein binding 新闻学会 11463333|18029035
GO:0004221 泛素thiolesterase活动 IEA -
GO:0008270 zinc ion binding IEA -
GO:0008234 cysteine-type peptidase activity IEA -
GO:0008233 peptidase activity IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0016579 protein deubiquitination IEA -
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade IDA 11463333
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 11463333
GO:0005737 cytoplasm IDA 11463333
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-137 847 853 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-146 380 386 1A hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrain UGAGAACUGAAUUCCAUAGGCU
miR-153 1557 1564 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-19 1428 1435 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-218 420 426 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-320 1483 1489 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-448 1558 1564 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-495 1143 1149 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-9 396 402 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA