Gene Page:CTNNBIP1

概括?
基因 56998
象征 CTNNBIP1
Synonyms ICAT
Description catenin beta interacting protein 1
Reference MIM：607758|HGNC:HGNC:16913|Ensembl:ENSG00000178585|HPRD:09677|Vega:OTTHUMG00000001796
Gene type protein-coding
Map location 1p36.22
Pascal p-value 0.613
Sherlock p-value 0.126
Fetal beta 0.35
DMG 1 (# studies)
eGene Cerebellar Hemisphere
额叶皮质BA9

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0069

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21604136 1 9910137 CTNNBIP1 1.979E-4 0.358 0.035 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconceptionweeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008013 beta-catenin binding IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO：0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
去：0006355 regulation of transcription, DNA-dependent TAS 10898789
GO:0009952 anterior/posterior pattern formation IEA -
GO:0007165 signal transduction TAS 10898789
GO:0008283 cell proliferation TAS 10898789
GO:0007275 multicellular organismal development TAS 10898789
GO:0030178 Wnt受体信号通路的负调控 IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 细胞质 IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
bend5 C1orf165 | FLJ11588 BEN domain containing 5 两个杂交 BioGRID 16189514
CASP4 ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TX caspase 4, apoptosis-related cysteine peptidase Affinity Capture-MS BioGRID 17353931
CPVL HVLP | MGC10029 carboxypeptidase, vitellogenic-like Affinity Capture-MS BioGRID 17353931
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa - HPRD,BioGRID 10898789
CTSA GLB2 | GSL | NGBE | PPCA | PPGB cathepsin A Affinity Capture-MS BioGRID 17353931
GLB1 EBP | ELNR1 半乳糖苷酶，β1 Affinity Capture-MS BioGRID 17353931
GOT2 FLJ40994 | KAT4 | KATIV | mitAAT 谷氨酸 - 奥氧乙酰氨基激酶2，线粒体（天冬氨酸氨基转移酶2） Affinity Capture-MS BioGRID 17353931
JUP ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB 交界处Plakoglobin Affinity Capture-MS
两个杂交		 BioGRID 16189514|17353931
NACAP1 FKSG17 新生的多肽相关复合α多肽假基因1 Affinity Capture-MS BioGRID 17353931
PNMA2 KIAA0883 |ma2 |MM2 |RGAG2 paraneoplastic antigen MA2 Affinity Capture-MS BioGRID 17353931
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform Affinity Capture-MS BioGRID 17353931
RPA3 repa3 replication protein A3, 14kDa Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG WNT SIGNALING PATHWAY 151 112 该途径中的所有SZGR 2.0基因
WNT SIGNALING 89 71 该途径中的所有SZGR 2.0基因
PID BETA CATENIN NUC PATHWAY 80 60 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA DN 526 357 该途径中的所有SZGR 2.0基因
JAEGER METASTASIS DN 258 141 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 该途径中的所有SZGR 2.0基因
WANG RESPONSE TO BEXAROTENE UP 34 17 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 该途径中的所有SZGR 2.0基因
GEORGES TARGETS OF MIR192 AND MIR215 893 528 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
BAELDE DIABETIC NEPHROPATHY DN 434 302 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 TARGETS DN 543 317 该途径中的所有SZGR 2.0基因
MARTINEZ TP53 TARGETS DN 593 372 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 该途径中的所有SZGR 2.0基因
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 该途径中的所有SZGR 2.0基因
BOCHKIS FOXA2 TARGETS 425 261 该途径中的所有SZGR 2.0基因
WINNEPENNINCKX MELANOMA METASTASIS DN 46 26 该途径中的所有SZGR 2.0基因
KARLSSON TGFB1 TARGETS DN 207 139 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-10 511 517 m8 HSA-MIR-10A UACCCUGUAGAUCCGAAUUUGUG
HSA-MIR-10B UACCCUGUAGAACCGAAUUUGU
miR-145 407 414 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-192/215 362 368 m8 hsa-miR-192 CUGACCUAUGAAUUGACAGCC
hsa-miR-215 AUGACCUAUGAAUUGACAGAC
miR-23 379 386 1A,m8 hsa-miR-23abrain aucacauugccagggauucc
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367 571 577 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-26 542 548 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-29 350 356 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-323 379 385 1A hsa-miR-323brain gcacauuacggucgaccucu