Gene Page:PSMC2

Summary?
GeneID 5701
Symbol PSMC2
Synonyms MSS1|Nbla10058|S7
Description proteasome 26S subunit, ATPase 2
Reference MIM:154365|HGNC:HGNC:9548|Ensembl:ENSG00000161057|HPRD:01105|Vega:OTTHUMG00000157206
Gene type protein-coding
Map location 7q22.1-q22.3
Pascal p-value 0.896
Sherlock p-value 0.579
Fetal beta -0.021
DMG 2 (# studies)

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
DNM:Guipponi_2014 Whole Exome Sequencing analysis 49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
PSMC2 G T NM_002803 p.E199D missense 0.02 0.55 Schizophrenia DNM:Guipponi_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06251958 7 102989081 PSMC2 4.421E-4 0.377 0.045 DMG:Wockner_2014
cg27109647 7 102988186 PSMC2 -0.021 0.64 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NPTXR 0.79 0.79
GDA 0.78 0.73
ATP2B4 0.78 0.70
ZNF831 0.77 0.55
PTPRR 0.77 0.80
HPCAL4 0.76 0.77
NCAM2 0.76 0.73
GLRA3 0.75 0.72
MAPK1 0.75 0.72
RAB27B 0.73 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SH2D2A -0.32 -0.36
C21orf57 -0.32 -0.29
AS3MT -0.31 -0.29
SNHG12 -0.30 -0.33
AC132872.1 -0.30 -0.31
RBMX2 -0.30 -0.29
BCL7C -0.29 -0.31
RPL23A -0.29 -0.27
RP9P -0.29 -0.36
HEBP2 -0.28 -0.34

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
GRINL1A DKFZp586F1918 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A Two-hybrid BioGRID 16169070
GTF2B TF2B | TFIIB general transcription factor IIB in vitro
in vivo		 BioGRID 11118327
GTF2F1 BTF4 | RAP74 | TF2F1 | TFIIF general transcription factor IIF, polypeptide 1, 74kDa - HPRD 11118325
GTF2H1 BTF2 | TFB1 | TFIIH general transcription factor IIH, polypeptide 1, 62kDa - HPRD,BioGRID 11118327
PAAF1 FLJ11848 | PAAF | Rpn14 | WDR71 proteasomal ATPase-associated factor 1 Affinity Capture-MS BioGRID 17353931
PSMC1 MGC24583 | MGC8541 | P26S4 | S4 | p56 proteasome (prosome, macropain) 26S subunit, ATPase, 1 - HPRD,BioGRID 10625621
PSMC4 MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7 proteasome (prosome, macropain) 26S subunit, ATPase, 4 - HPRD,BioGRID 11361004
PSMD10 dJ889N15.2 | p28 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Affinity Capture-MS BioGRID 17353931
PSMD13 HSPC027 | Rpn9 | S11 | p40.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Affinity Capture-MS BioGRID 17353931
PSMD2 MGC14274 | P97 | Rpn1 | S2 | TRAP2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 - HPRD,BioGRID 10625621
PSMD5 KIAA0072 | MGC23145 | S5B proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 - HPRD,BioGRID 10625621
PSMD6 KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Affinity Capture-MS BioGRID 17353931
TBP GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID TATA box binding protein - HPRD,BioGRID 11118327
TRAF6 MGC:3310 | RNF85 TNF receptor-associated factor 6 Affinity Capture-MS BioGRID 14743216


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PROTEASOME 48 28 All SZGR 2.0 genes in this pathway
BIOCARTA PROTEASOME PATHWAY 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 65 41 All SZGR 2.0 genes in this pathway
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 48 29 All SZGR 2.0 genes in this pathway
REACTOME抗原处理铬OSS PRESENTATION 76 48 All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 61 40 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN 67 37 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 97 66 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 64 43 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 51 31 All SZGR 2.0 genes in this pathway
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 48 27 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 49 33 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS 58 34 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 57 35 All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 81 45 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 56 31 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 51 30 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 85 46 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 36 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 53 31 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 72 38 All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 73 40 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 64 34 All SZGR 2.0 genes in this pathway
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 51 32 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
REACTOME抗原PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 56 34 All SZGR 2.0 genes in this pathway
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 52 30 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
BARRIER COLON CANCER RECURRENCE UP 42 28 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS 49 33 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 72 45 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 49 38 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 UP 22 14 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway